Contraction stimulates Na+,K+-ATPase and AMP-activated protein kinase(AMPK)activity in skeletal muscle. Whether AMPK activation affects Na+,K+-ATPase activity in skeletal muscle remains to be determined. Short term stimulation of rat L6 myotubes with the AMPK activator 5-aminoimidazole-4-carboxamide- 1-β-D-ribofuranoside (AICAR), activates AMPK andpromotes translocation of the Na+,K +-ATPase α1-su

Statement of Purpose: Many chronic pulmonary diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension (PH) and chronic obstructive pulmonary disease (COPD), are complex and poorly understood. While great progress has been made to elucidate the cellular and molecular pathways underlying these diseases, treatment options remain limited. The dynamic alterations in mechanical pr

Introduction: Body awareness is a movement therapy used in Physical Therapy in Mental Health especially in Scandinavia. The method Basic Body Awareness Therapy has been scientifically investigated in particular for patients with Depression, Schizophrenia and Post Traumatic Stress Syndrome (PTSD). Methods: Thirty-four Physical Therapists from 13 countries working with the Basic Body Awareness Thera

This presentation addresses questions concerning the relationship between 1st, 2nd and 3rd cycles in higher music education (HME), and the transformative possibility of artistic research in conservatoire contexts. In the conservatoire tradition, knowledge and experience of music as both a craft and an art is held, transmitted and developed. Previous research shows that young students of classical

This study is the first attempt to examine the effect of electronic word of mouth (user reviews) relative to expert reviews on moviegoing decisions. For the first time, we use time-varying data on expert reviews. We find that expert ratings matter much more for moviegoing decisions than user ratings and volume. Our data also show that experts tend to be more critical but more consistent in their r

This study investigates the relationship between grain-size distributions and sediment transport processes at Ängelholm Beach in southwest Sweden. In total, 308 longshore and cross-shore distributed sediment samples are analysed with respect to median grain size and sorting. The longshore sediment transport is almost unidirectional from north to south. Its gradients cause erosion in the north and

Paperboard mechanical properties at fracture during uniaxial tests is an interplay between available elastic energy at fracture and the fracture energy needed to separate the sample into two parts. A test at a critical length, the load vs. elongation curve immediately falls from a point of instability to zero load. Whereas, a test at a stable length give a stable descending load-elongation curve wPaperboard mechanical properties at fracture during uniaxial tests is an interplay between available elastic energy at fracture and the fracture energy needed to separate the sample into two parts. In a test at a critical specimen length, the load vs. elongation curve immediately drops from a point of instability to zero load, whereas a test at a stable length gives a stable descending load-elonga

We have examined the binding of [3H]bradykinin to bovine myometrial membranes and assessed its sensitivity to guanine nucleotides. Total binding displayed a typical B2 kinin receptor specificity. However, saturation binding isotherms were resolved into at least two components with K(D) values of 8 pM (45%) and 378 pM (55%). Low affinity binding exhibited relatively rapid rates of association (k(ob

Purpose: The purpose of the study, upon which this paper is based, was to contribute an improved understanding of the vertical extension of buildings, by presenting a development process for its implementation in which the key aspects to consider when planning such extensions are highlighted. Design/methodology/approach: The approach is based on linking the diffusion of innovation together with ca

Abstract: The adrenergic receptors of rat pineal gland were investigated using radiolabeled ligand binding and photoaffinity labeling techniques. 125I‐2‐[β‐(4‐hydroxyphenyl)ethylaminomethyl]tetralone (125I‐HEAT) and 125I‐cyanopindolol (125I‐CYP) labeled specific sites on rat pineal gland membranes with equilibrium dissociation constants (KD) of 48 (±5) pM and 30 (±5) pM, respectively. Binding site

This chapter examines the communicational dynamic between adaptive and flexible CSOs. It focuses on women’s issues and citizen protest movements on the one hand, and political parties on the other, against the background of the extended protests that took place in Romania in the first half of 2012. These protests led to two changes in the government coalition and a significant reshuffling of the R

DDT1 MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain α1-adrenergic receptors (54,800 ± 2700 sites per cell) that are coupled to stimulation of inositol phospholipid metabolism. Incubation of these cells with tumor-promoting phorbol esters, which stimulate calcium- and phospholipid-dependent protein kinase, leads to a marked attenuation of the ability of α1-receptor a

We have synthesized and characterized a high-affinity alpha1-adrenergic receptor probe, 4-amino-6,7-dimethoxy-2[4'-[5''-(3-125I-iodo-4-aminophenyl)pentan oyl]-1'-piperazinyl]quinazoline (125I-A55453). This ligand binds reversibly to rat hepatic plasma membranes with high affinity (K(D) = 77 ± 6 pM), and it labels the same number of 'specific' prazosin-competable sites as the alpha1-adrenergic rece

We have synthesized and characterized a novel high affinity radioiodinated α1-adrenergic receptor photoaffinity probe, 4-amino-6,7-dimethoxy-2-[4-[5-(4-azido-3-[125I]iodophenyl)pentanoyl]-1-p iperazinyl] quinazoline. In the absence of light, this ligand binds with high affinity (K(D) = 130 pM) in a reversible and saturable manner to sites in rat hepatic plasma membranes. The binding is stereoselec

Tumor promoting phorbol esters stimulate Ca++ phospholipid-dependent protein kinase C. It has been suggested that this enzyme regulates the functional properties of different cell membrane receptors. In this study we investigated the effect of phorbol esters on α1-adrenoceptor binding and phosphatidylinositol metabolism in cultured smooth muscle cells derived from rabbit aorta. Treatment of these