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Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is known for the recognisable motor symptoms. The cause of the disease is the loss of a specific cell type in the brain, called dopaminergic (DA) neurons. Significant steps towards stem cell replacement therapy of DA neurons have been made in the last few decades. Despite that, one aspect has been quite overlooked

As time is moving forward, the world is becoming more dependent on Internet of Things (IoT) devices. The vision for the future involves IoT devices participating in various aspects of our daily lives, including sensing, controlling, and communicating. Such a future requires a significant number of IoT devices, which raises questions regarding sustainability in terms of battery waste. One promising

Towards personalized treatment: Improved tools for bladder cancer classification Cancer research has taken a leap forward with the emergence of precision medicine, which aims to tailor treatments to the unique characteristics of each patient’s tumor. IN the case of bladder cancer, a complex and diverse disease, understanding its molecular subtypes is crucial for accurate prognosis and treatment r

I denna uppsats studerar vi en matematisk modell av vattenvågor över djupt vatten. I synnerhet studerar vi vågor som färdas med konstant hastighet i en horisontell riktning och är likformiga i den vinkelräta horisontella riktningen. På grund av den matematiska svårigheten med den allmänna modellen är det vanligt att utgå från förenklade versioner av problemet. I denna uppsats, gör vi antaganden omIn a recent paper, Hur and Wheeler proved the existence of periodic steady water waves over an infinitely deep, two-dimensional and constant vorticity flow and subject to gravity whose profile overhangs, among which, waves whose surface touches at a point, enclosing a bubble of air. We take this further, proving the existence of a continuous curve of water waves from a laminar flow up to a touchin

”Du är vad du äter” – lider urbana talgoxungar av Omega 3-brist? Livet i städer medför många bekvämligheter, inte bara för oss människor, utan även för en del vilda arter av djur som lyckats anpassa sig till förutsättningarna i dessa miljöer. För de djur som kan livnära sig på mänskligt matavfall, eller för fåglar som vi människor har en fäbless för att mata kan livet i staden till exempel erbjudIt has been known for quite some time that urban breeding birds suffer reduced reproductive success compared to rural conspecifics. Various environmental variables linked to urbanisation are known to have an influence, such as vegetal cover and composition, artificial light at night as well as increased air pollution. Several of these factors have also been shown to elicit physiological responses:

As the “engine of life”, metabolic rate is one of the most well-studied physiological traits across the animal kingdom. Metabolic rates have been linked to key physiological and life-history traits as well as to large scale ecological processes. For decades, scientists have tried to understand and explain metabolic allometry – the relationship between metabolic rate MR and body mass M (MR = bMa).

In the context of China’s concerning decline in fertility rates and the widespread normalization of the ‘996’ overtime culture, the connection between overtime work and fertility assumes considerable importance. This research is firmly grounded in the theoretical framework of the Theory of Planned Behavior (Ajzen, 1991), which investigates the complex relationship between overtime work and fertili

After realising vibrato is such an essential resource in strings and it can affect the quality of sound, I decided to reflect on it. The thesis is divided into two source parts, Vibrato subdivided in definition, terminology, evolution and the four main types and Dvořák subdivided in a brief composer's biography, the evolution in his aesthetics, and the context of composition of the concerto, o

Pramipexole is a medication that normalises dopamine signalling in the brain. Previous studies have suggested that pramipexole is an effective treatment option for depression and anhedonia because it targets the dopaminergic pathways within the brain’s reward network. The nucleus accumbens is a crucial region for dopamine signalling in reward processing. Both task-based and resting-state fMRI evid

This research aims to investigate the motivational aspects of gamification elements on the in-ter-organizational knowledge-sharing platform, Stack Overflow. The study addresses the gaps in existing research by providing an in-depth analysis of gamification elements' effects and exploring top contributors' motivation to share knowledge. It follows a qualitative approach, conducting semi-str

Uppsatsen undersöker religiösa aktörers sociala insatser under mottagningskrisen i Sverige 2015 och 2016. Under mottagningen av 160 000 personer på flykt behövde myndigheterna ta stöd i civilsamhällesorganisationer, varav många religiösa aktörer engagerade sig i mottagningsarbete på olika sätt. Uppsatsen syftar till att skapa förståelse för hur och varför religiösa aktörer bedriver sociala insatseThe essay examines the social work of religious actors during the reception crisis in Sweden in 2015 and 2016. During the reception of 160,000 refugees, the authorities needed support from civil society organizations, many of which involved religious actors in the reception work in various ways. The essay aims to create an understanding of how and why religious actors carry out social work in the

Genrepedagogikens genomslag i en digitaliserad skola innebär att skrivundervisningens lärresurser i hög grad utgörs av olika typer av modelltexter. Läromedelsutredningen (SOU 2021:70) utförd på uppdrag av regeringen synliggör en spänning mellan den fysiska läroboken och alternativa undervisningsmaterial, men också att forskningen om hur lärresurser används i Sverige är begränsad. Syftet med denna Teaching and Learning Resources in Genre Pedagogy – The Role of Teaching and Learning Materials in the Development of Students’ Non-Fiction Writing Skills The impact of genre pedagogy in a digitalised school means that the resources for teaching writing are largely made up of different types of model texts. Läromedelsutredningen (SOU 2021:70) carried out on behalf of the government highlights a t

The issue of freedom of expression in the context of Turkey and the European Court of Human Rights (‘ECtHR’ or ‘the Court’) has been widely discussed from legal perspectives. Especially, with the changing political, legal and social dynamics in Turkey within 2003-2022, the case-law of the Court increased by a considerable amount. All the contingencies affecting the argumentative and interpretive a

The main goal of this project is to explore tools for consumers and designers when consuming or developing long lasting furniture and translating the results into a pro- duct. The short life span of today’s furniture is due to design and material choices hindering graceful aging. This contributes to fast furniture, discarded prematurely due to breaking or aesthetic downgrading. After a literature

Since the 1970s, neoliberal policies worldwide have been affecting the organization of care in welfare regimes and the working conditions of care workers. Although it takes different forms in different welfare regimes, studies show that it is a global phenomenon in which care workers endure poor working conditions such as low wages, heavy workload, and sexual harassment. Using the Social Reproduct

Tomträtter har varit ett omdiskuterat ämne sen avgälderna började sättas till ett mer marknadsmässigt pris. De ökande avgälderna gör att möjligheten att friköpa tomträtter blir intressant för de som har sin bostad på en tomträtt. I vissa kommuner utgör tomträtter en betydande andel av småhusfastighetsutbudet. Syftet med studien är att undersöka hur tomträttsstatusen påverkar betalningsviljan för sThis study aims to examine the effect of leasehold status on the selling price for houses. The study focuses on houses sold in Stockholm and Gothenburg during 2018 and 2019. Municipalities in Sweden have since 1907 offered leased land as an alternative to owned land to facilitate for more people to build homes. The leasehold holders pay a yearly rent to the owner of the land. The payment contracts

Detta examensarbete är en fallstudie av Tumaini Open School för gravida studenter och studerande mödrar i Tabora, Tanzania. Genom den ideella organisationen Ingenjörer utan gränser Sverige genomförde författarna en Minor Field Study i Tanzania för att fastställa efterfrågade eltjänster, det resulterande elbehovet och den maximala dagliga effektkurvan för skolan vid fullskalig verksamhet. Vidare prThis master thesis is a case study of Tumaini Open School for pregnant and mothering students located in Tabora, Tanzania. Through the volunteer organisation Engineers Without Borders Sweden, the authors conducted a Minor Field Study to Tanzania in order to determine the requested electricity services, resulting electricity demand and maximum daily load profile for the school at full-scale operati

Transposable elements make up over 50% of the human genome and serve beneficial transcriptional regulatory roles but can also exert deleterious effects when aberrantly expressed. Four de novo missense mutations in the master regulator of transposable elements – corepressor TRIM28 – were identified in four patients with intellectual disability suggesting that dysfunctional transposable element regu

Ocean acidification, warmer temperatures, and the expansion of hypoxic zones in coastal areas are direct consequences of the increase in anthropogenic activities. However, so far, the combined effects of these stressors on calcium carbonate-secreting marine microorganisms - foraminifera are complex and poorly understood. This study reports the foraminiferal survival behavior, and geochemical tr