För att kunna förstå och beskriva universum behövs det mer materia än den vi ser och kan förklara med standardmodellen för partikelfysik. Den materia som vi ser och kan ta på utgör bara en bråkdel av den materian som finns i vårt universum. Det som fattas, det som vi inte kan se men enligt observationer och beräkningar finns där, kallas mörk materia. Den kallas mörk materia då den inte reflekterarDark matter is one of our universe’s largest mysteries and very little is known about what it is. One of the dominating theories, that it originates from an early universe thermal relic, indicates that it has interaction with the Standard Model. If this is the case, dark matter can be produced at accelerators and detected indirectly by searching for missing momentum signals. LDMX will join this se

Detection of c-di-GMP level in Bacillus subtilis with Biosensors Cyclic dinucleotides are signaling molecules that control several critical processes in bacteria. The most studied example is cyclic dimeric guanosine 3',5'-monophosphate (c-di-GMP) which is a universal bacterial second messenger. C-di-GMP is known to affect several cellular processes such as biofilm formation and dispersion

Alexander’s Disease is a progressive neurological disorder caused by a wide array of dominant, gain of function mutations in the GFAP gene. The disorder is characterized by the accumulation of GFAP in astrocytes, leading to the formation of protein inclusion bodies known as Rosenthal fibers. This results in a disruption of astrocytic function and the subsequent degeneration of white matter. Howeve

Understanding the effect of Myc on lung cancer immune signalling in vitro and in vivo Immune checkpoint blockade therapy (ICBT) is a promising treatment option that is commonly used for advanced non-small cell lung cancer (NSCLC). Immune checkpoint inhibitors targeting the PD-1/PD-L1 interaction have demonstrated remarkable effects. Blocking the PD-1/PD-L1 axis restores tumor cell recognition and

Background: The Emergency Department (ED) has increasingly been recognized as an important site of care for older adults with unmet palliative care needs. Despite this, no clear model of care delivery has emerged. Aim: To assess the acceptability and feasibility of a scripted palliative care communication intervention in the ED directed by social workers. We hypothesized that the intervention woul

Objective To update the epidemiology of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) in a defined geographical area of southern Sweden.Methods The study area comprised 14 municipalities with a combined adult population (≥18 years) of 623 872 in 2019. All cases diagnosed with AAV in 1997–2019 in the study area were included in the estimate of incidence. Diagnosis of AAV was veri

Background: No reliable instruments exist to measure prognostic awareness and its psychological and behavioral impacts for patients with advanced cancer. Methods: We developed the Prognostic Awareness Impact Scale (PAIS) using a qualitative approach. During phase 1, we convened a working group with a transdisciplinary team of clinicians from oncology (n = 2), psychology (n = 2), psychiatry (n = 1)

Objective: 1-2 ‰ of newborns in Sweden are identified with a permanent, habilitation- required hearing impairment at neonatal hearing screening. Traditionally, focus is on the child when diagnosed; the parents’ needs and concerns are not always recognised. The current study aims to elucidate parents’ narratives of their experiences of the process of diagnosis and habilitation of their child with c

Palliative care supports referring colleagues in multiples ways. This support to referring colleagues is not often explored in the literature, yet the psychological concept that best describes it is the holding environment. The holding environment is the relational space palliative care offers referring clinicians for processing emotions and information. Using the case of Gloria, a patient living

Objective Although important treatment decisions are made in the Emergency Department (ED), conversations about patients’ goals and values and priorities often do not occur. There is a critical need to improve the frequency of these conversations, so that ED providers can align treatment plans with these goals, values, and priorities. The Serious Illness Conversation Guide has been used in other c

Maternal boost early in life alter rotavirus specific immune response on infants The first period of life for infants goes through by depending on their mother’s antibody transfer, primarily because of the infant’s immune system is still under development while being exposed to pathogens. Maternal antibody transfer is achieved through placenta during pregnancy and continues past birth through bre

Denna avhandling handlar om kapitalistisk stadsförnyelse och regleringen av bostadsfattigdom i Mumbai. Avhandlingen undersöker hur stadsutvecklingsregimer formar omflyttningar och styrning av befolkningen i Mumbai. Författaren använder etnografiskt utforskande av två storskaliga projekt: transportexpansion och pipelinesäkerhet samt två omlokaliserade samhällen och deras socio-politiska dynamik på This dissertation concerns capitalist urban redevelopment and the government of urban housing poverty. It examines the ways urban redevelopment regimes shape resettlements and governance of urban populations in Mumbai. The specific enquiries focus on salient accumulative and dispossessive dimensions of urban redevelopment and linked resettlement construction, the reformation of informal politics o

Deep learning, the study of multi-layered artificial neural networks, has received tremendous attention over the course of the last few years. Neural networks are now able to outperform humans in a growing variety of tasks and increasingly have an impact on our day-to-day lives. There is a wide range of potential directions to advance deep learning, two of which we investigate in this thesis:(1) O

A 39-year-old nulliparous woman with a previously known cervical myoma was admitted to the obstetrics department during the first trimester with complaints of severe abdominal pain, lack of bowel movements and the suspicion of a clinical bowel obstruction. Because no literature on this exact condition could be found, clinical decisions were based on reports and practice in similar situations. Ultr

BACKGROUND: Imaging ovarian cancer (OC) includes evaluating peritoneal carcinomatosis (PC) and enlarged cardio phrenic lymph nodes (CPLN) by computed tomography (CT), and thorough evaluation is tedious work. A "CT short score" with high-risk CT parameters might be a more pragmatic approach, but it is not known if such a short score associates with aggressive OC subtypes and impaired OC survival. F

Background: Aβ42/Aβ40 ratios in cerebrospinal fluid (CSF) and blood are reduced in preclinical Alzheimer’s disease (AD), but their temporal and correlative relationship with cerebral Aβ pathology at this early disease stage is not well understood. In the present study, we aim to investigate such relationships using App knock-in mouse models of preclinical AD. Methods: CSF, serum, and brain tissue