Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. In Parkinson's disease, nigrostriatal midbrain dopaminergic neurons degenerate and cause typical Parkinson's disease motor-related impairments, while the dysfunction of mesocorticolimbic midbrain dopaminergic neurons is implicated in addiction and n

Cardiometabolic diseases are the leading preventable causes of death in most geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic diseases vary greatly worldwide, as do the resources and strategies needed to prevent and treat them. Therefore, there is no single solution and health care should be optimised, if not to the individual (ie, personalised health care), the

Background: Research on ethnic and socioeconomic treatment differences following in-hospital cardiac arrest (IHCA) largely draws on register data. Due to the correlational nature of such data, it cannot be concluded whether detected differences reflect treatment bias/discrimination – whereby otherwise identical patients are treated differently solely due to sociodemographic factors. To be able to

The antigen receptor loci are the only loci in humans to undergo programmed somatic gene modification. Although aberrant V(D)J integration and class switch recombination can both give rise to chromosomal translocations, a role for somatic hypermutation in such genomic rearrangements has been suggested but is less clearly established. To characterize the types of by-products of somatic hypermutatio

This thesis explores the potential of integrating predicted founder personalities, based on the Big 5 Personality Framework, into Machine Learning (ML) models to enhance the accuracy of early-stage startup success predictions. Leveraging Natural Language Processing (NLP) techniques, we extracted personality insights from founders' tweets, focusing on US startups funded between 2013 and 2015. O

We prove a new explicit inequality for the non-dimensional flow force constant, significantly improving the Benjamin and Lighthill conjecture about irrotational steady water waves. As a corollary, we prove a bound for the wave amplitude in terms of the Bernoulli constant. We show that the amplitude decays as r−2 when r→+∞, where r is the non-dimensional Bernoulli constant. We explain that the latt

Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation o

Two-dimensional steady gravity driven water waves with vorticity are considered. Using a multidimensional bifurcation argument, we prove the existence of small-amplitude periodic steady waves with an arbitrary number of crests per period. The role of bifurcation parameters is played by the roots of the dispersion equation.

Plant morphogenesis is governed by the mechanics of the cell wall—a stiff and thin polymeric box that encloses the cells. The cell wall is a highly dynamic composite material. New cell walls are added during cell division. As the cells continue to grow, the properties of cell walls are modulated to undergo significant changes in shape and size without breakage. Spatial and temporal variations in c

We consider the nonlinear problem of steady gravity-driven waves on the free surface of a two-dimensional flow of an inviscid, incompressible fluid (say, water). The water motion is supposed to be rotational with a Lipschitz continuous vorticity distribution, whereas the flow of finite depth is assumed to be unidirectional. We verify the Benjamin-Lighthill conjecture for flows with values of Berno

Background: Severe left-sided cardiac obstructions are associated with high morbidity and mortality if not detected in time. The correct prenatal diagnosis of coarctation of the aorta (CoA) is difficult. Fetal cardiac magnetic resonance imaging (CMR) may improve the prenatal diagnosis of complex congenital heart defects. Flow measurements in the ascending aorta could aid in predicting postnatal Co

If the Anthropocene marks a changed way of being in the world resulting from the integration of human activity and geological processes, a main question is how this situation may be aesthetically represented and with what implications. This article sketches an aesthetics of the Anthropocene by analyzing artistic engagements with advanced tools of visual calculation used in the context of the envir