Advanced Parkinson's disease (PD) is characterized by motor fluctuations including unpredictable oscillations remarkably impairing quality of life. Effective management and development of novel therapies for these response fluctuations largely depend on clinical rating instruments such as the widely-used PD home diary, which are associated with biases and errors. Recent advancements in digital hea

Climate policies are often assumed to have significant impacts on the nature and speed of energy transitions. To investigate this hypothesis, we develop an approach to categorise, trace, and compare energy transitions across countries and time periods. We apply this approach to analyse electricity transitions in the G7 and the EU between 1960 and 2022, specifically examining whether and how climat

Place branding is defined as “the development of brands for geographic locationswith the aim of triggering positive associations about the area and distinguishinga place from other places” (Stevens et al., 2020, p. 752). Like all occupations,place branding is organised by discourses, or talk, that determine best practices andnorms about what constitutes expertise (Loacker and Sullivan, 2016). Expl

Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children within 12 months prior to the appearance of type 1 diabetes-linked islet autoantibodies

Climate warming increases carbon assimilation by plant growth and also accelerates permafrost CO2 emissions; however, the overall ecosystem CO2 balance in permafrost regions and its economic impacts remain largely unknown. Here we synthesize in situ measurements of net ecosystem CO2 exchange to assess current and future carbon budgets across the northern permafrost regions using the random forest

The UPCA for the first time establishes harmonized exceptions and limitations to the effects of granted patent rights. Previously these were the sole province of national law but a with a degree of similarity.This chapter briefly analyses the historical origin, legal nature and scope of Article 27 UPCA, the future harmonizing effect of UPCA patent limitations, followed by a discussion on each limi

Den boreala regionen innehåller 40% av jordens kol (C) som lagras i vegetation och mark med sina skogar som står för nästan 30% av den terrestra C sänkan. Boreala skogar upplever några av de snabbaste hastigheterna för klimatuppvärmning och ökningar i brandaktivitet, vilket hotar att släppa ut stora mängder av deras C reserver till atmosfären. Även om klimat och skogsbränder har stark kontroll öveThe boreal region contains 40% of the earth’s carbon (C) that is stored in vegetation and soils with its forests accounting for almost 30% of the terrestrial C sink. Boreal forests are experiencing some of the most rapid rates of climatic warming and increases in fire activity, threatening to release large amounts of their dense C reserves to the atmosphere. While climate and wildfire place strong

Archamoebae comprises free-living or endobiotic amoebiform protists that inhabit anaerobic or microaerophilic environments and possess mitochondrion-related organelles (MROs) adapted to function anaerobically. We compared in silico reconstructed MRO proteomes of eight species (six genera) and found that the common ancestor of Archamoebae possessed very few typical components of the protein transl