We show that entrepreneurs are co-located within cities. One plausible source of such spatial clustering is local social interactions, where individuals' decisions to become entrepreneurs are influenced by entrepreneurial neighbors. Using geo-coded matched employer-employee data for Sweden, we find that sharing residential neighborhood with established entrepreneurs has a statistically significant

The aim of the present study is to investigate associations between parental separation/divorce during childhood, and self-reported psychological health, adjusting for social capital, social support, civil status and economic stress in childhood. A cross-sectional public health survey was conducted in the autumn of 2012 in Scania, southern Sweden, with a postal questionnaire with 28,029 participan

“Collaboration” is generally portrayed as being beneficial to intelligence and operational police work, even if previous collaborative research shows that conflicts are common between authorities who are supposed to cooperate. The present study focuses on how officers collaborate in their day-to-day management of borderguarding, taking into consideration the different social and cultural backgroun“Collaboration” is generally portrayed as being beneficial to intelligence and operational police work, even if previous collaborative research shows that conflicts are common between authorities who are supposed to cooperate. The present study focuses on how officers collaborate in their day-to-day management of border guarding, taking into consideration the different social and cultural backgrou

This paper ad to the body of knowledge on the implementation of the e-Government and aims to describe how this process was carried out in a municipality in Northern Italy. This organization is a public organization in an economically important region and provides services to entrepreneurs such as validation for opening a new business. A case study approach used with several interviewees including

The Late Ordovician mass extinction (LOME) coincided with dramatic climate changes, but there are numerous ways in which these changes could have driven marine extinctions. We use a palaeobiogeographic database of rhynchonelliform brachiopods to examine the selectivity of Late Ordovician-Early Silurian genus extinctions and evaluate which extinction drivers are best supported by the data. The firs

Leukemias are a group of life threatening malignant disorders of the blood and bone marrow. In the adolescent and young adult (AYA) population, the acute leukemias are most prevalent, with chronic myeloid leukemia being infrequently seen. Factors associated with more aggressive disease biology tend to increase in frequency with increasing age, whilst tolerability of treatment strategies decreases.

The South American Altiplano in the Andes is, aside from Tibet, the most extensive high plateau on Earth. This semiarid area represents important water resources storages, including the Lakes Titicaca and Poopó located in the northern and central Altiplano, respectively. The two lake basins and the southern saltpans constitute a large watershed, called the Lake Titicaca, Desaguadero River, Lake Po

A systematic method is presented whereby material from a full course of psychoanalytic treatment is analyzed to assess changes and identify patterns of change. Through an analysis of session notes, changes were assessed using the CHange After Psychotherapy scales (CHAP; Sandell 1987a), which evaluate changes in five rating variables (symptoms, adaptive capacity, insight, basic conflicts, and extra

Aims: Bacterial infection is a major challenge in wound care. Antimicrobial wound dressings are of great value for treating wound infections. Endolysins are evolving as a new class of antimicrobials with multiple applications. This study describes the production and evaluation of T4 lysozyme (T4Lyz), product of gene e of the T4 bacteriophage, fused with Cellulose Binding Module (CBM) for facile im

The kinetics and mechanism of the reactions between trans-[PtI3(PPh3)]– and trans-[PtI3(SbPh3)]– with pyridine, 2- and 4-methylpyridine in acetonitrile solvent have been studied by stopped-flow spectrophotometry. The crystal and molecular structures of the tetrabutylammonium salts of the two anions have been determined. Substitution of iodide trans to stibine is reversible and takes place via paraThe kinetics and mechanism of the reactions between trans-[PtI3(PPh3)]– and trans-[PtI3(SbPh3)]– with pyridine, 2- and 4-methylpyridine in acetonitrile solvent have been studied by stopped-flow spectrophotometry. The crystal and molecular structures of the tetrabutylammonium salts of the two anions have been determined. Substitution of iodide trans to stibine is reversible and takes place via para

This paper presents a wideband quadrature radio receiver employing ΔΣ-based A/D-converting channel-select filters (ADCSFs). The output of the quadrature passive mixer is directly connected to the input of the ADCSFs, where a first-order ΔΣ modulator is incorporated into a fourth-order Butterworth channel-select filter (CSF) to provide sufficient dynamic range for a cellular system. A design method

Ecosystems can show sudden and persistent changes in state despite only incremental changes in drivers. Such critical transitions are difficult to predict, because the state of the system often shows little change before the transition. Early-warning indicators (EWIs) are hypothesized to signal the loss of system resilience and have been shown to precede critical transitions in theoretical models,

Vascular smooth muscle endothelin type B (ETB) receptor is involved in the pathogenesis of cardiovascular diseases (CVDs). Hyperhomocysteinemia is an independent risk factor for CVDs. The present study was designed to examine the hypothesis that homocysteine (Hcy) up-regulates vascular smooth muscle ETB receptors. In vitro experiments were performed in rat superior mesenteric artery (SMA) and vasc

The distribution of serotonin-like and FMRFamide-like immunoreactive (5HT-ir and FMRFa-ir, respectively) neurons in the nervous system of the chiton Lepidopleurus asellus (Mollusca, Polyplacophora) was studied using an immunocytochemical technique. The neurons were distributed in characteristic patterns in the central nervous system, the 5HT-ir neurons predominating in the ventral (pedal) cords an

In the land pulmonate snailCepaea nemoralis, immunocytochemical localization of methionine- and leucine-enkephalin-like substances was demonstrated in specific populations of brain neurons. Methionine-enkephalin reactivity is also present in the peripheral nervous system as (i) abundant axonal projections of central neurons to the sole of the foot, and (ii) sparse local neurons of the head and man

Bacterial polyhydroxyalkanoates (PHA) are expensive partly due to the recovery and purification processes. Thus, many studies have been carried out in order to minimize the cost. Here we report on the use of mealworm, which is the larva of mealworm beetle (Tenebrio molitor) to recover PHA granules from Cupriavidus necator. Mealworms were shown to readily consume the freeze-dried C. necator cells a

In this study we conceptualise how a capability approach could be used for analysing the conditions for preserving security of energy supply. We derive a concept, ‘energy system capability’, to describe how well the system is designed for this purpose. Based on a socio-technical systems perspective, we suggest that this capability is composed of five categories of ‘building blocks’: technical stru

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducible kinases (SIKs) control subcellular localization of HDAC4/5 and CRTC2. PTH regulates both HDAC4/5