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TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells

Background: Asthma exacerbations are commonly associated with rhinovirus (RV) infection. Interleukin-33 (IL-33) plays an important role during exacerbation by enhancing Type 2 inflammation. Recently we showed that RV infects bronchial smooth muscle cells (BSMCs) triggering production of interferons and IL-33. Here we compared levels of RV-induced IL-33 in BSMCs from healthy and asthmatic subjects,

Numerical Pitfalls in Q-Design

Q-design is a powerful method for designing approximately optimal LTI controllers and assessing the achievable control performance. Unfortunately, numerical issues are often encountered in Q-design which limits its applicability. This paper warns about two numerical pitfalls in Q-design when using H 2 costs and Laguerre-type basis functions.

The social network of people who attempt suicide

Social characteristics and self‐rating of social support by means of the Interview Schedule for Social Interaction were investigated in 75 inpatients after a suicide attempt. We found that very few suicide attempters (13%) had a well functioning relationship, and two‐thirds had problems in their occupational situation. Divorced patients had unsatisfactory social interaction compared with those who

Notified but Unaware: Third Party Tracking Online

Drawing from conceptual studies on transparency, particularly with regard to market complexity, user literacy and resignation, this article studies and analyzes the practices of third-party data collection online. Empirically, we map third-party trackers on a sample of Swedish websites in five sectors (media, retail, banking/insurance, public sector, and health), and the trackers are compared to l

The composition of the family

The chapter starts with an exploration of what the family is in order then to move on to look at its parts. The family has been defined in terms of its form (e.g. a mother, a father, and their biological offspring) or its function (e.g. adults taking and/or sharing custodial responsibility for children). In both of these cases, children are a necessary ingredient for a unit to be called a family –

Patients' aged ≥65 years dispositions during ambulance assignments, including factors associated with non-conveyance to hospital : A longitudinal and comparative study

Objectives Patients ≥65 years old represent 30%-50% of all ambulance assignments (AAs), and the knowledge of which care level they are disposed to is limited and diverging. The aim of this study was therefore to describe and compare characteristics of patients' aged ≥65 years dispositions during AA, including determining changes over time and factors associated with non-conveyance to hospitals. De

Active faulting and seismic hazard in the Outer Western Carpathians (Polish Galicia) : Evidence from fractured Quaternary gravels

This report opens a new window on Quaternary tectonics of the Outer Western Carpathians. We discuss results of fractured clasts analysis in Quaternary fluvial gravels within a 4.500 km2 large area comprising a part of the Outer Carpathians including Nowy Sącz Intramontane Basin (NSIB) as well as in the innermost part of the Carpathian Foredeep. Quaternary gravels bearing fractured clasts are wides