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Epigenetic mechanisms may contribute to idiopathic scoliosis (IS). We identified 8 monozygotic twin pairs with IS, 6 discordant (Cobb angle difference >10°) and 2 concordant (Cobb angle difference ≤2°). Genome‐wide methylation in blood was measured with the Infinium HumanMethylation EPIC Beadchip. We tested for differences in methylation and methylation variability between discordant twins and tes

In many Gram-positive bacteria, the redox-sensing transcriptional repressor Rex controls central carbon and energy metabolism by sensing the intra cellular balance between the reduced and oxidized forms of nicotinamide adenine dinucleotide; the NADH/NAD+ ratio. Here, we report high-resolution crystal structures and characterization of a Rex ortholog (Gbs1167) in the opportunistic pathogen, Strepto

Under senare år har flera satsningar gjorts på forskarskolor för lärare, i syfte att bygga upp skolans kunskapsbas och öka antalet lärare i skolan med utbildning på forskarnivå.Den här bokens innehåll baseras på resultaten från den nationella forskarskolan för språklärare De främmande språkens didaktik (FRAM) som bedrevs med stöd från Vetenskapsrådet under perioden 2012-2015.Forskarskolan möjliggj

The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at s√=8TeV. The dataset corresponds to an integrated luminosity of 20.2fb−1, and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron o

During the last few decades, education globally has been marked by being closely related to the economy. It always was, but today’s commodification and marketization reach into any aspect of the educational system (Ball, 2012; Bartlett et al., 2002). Sweden is a specific case at hand, since privatization and competition between schools have taken especially sinister forms, and have far-reaching ef

European Commission favours market-based support policies, such as markets for tradable green certificates, to promote renewable energy. Meanwhile, these instruments have received critique for exposing investors to large price risk as the level of support is determined by the market price of certificates. Using a two-step procedure, this study builds upon the work of Fagiani and Hakvoort (2014) by

This chapter discusses the preparation of stable radioiodinated polypeptide hormones and proteins using polyacrylamide gel electrophoresis. Radioactively labeled polypeptide hormones and proteins are widely used as tracers in radioimmunoassays and receptor studies. The peptide or protein is most easily labeled using iodination with 125I or 131I. The radioactive iodine is substituted in the tyrosin

Background: Neuronal calcium and ATP homeostasis is regulated through alterations in mitochondria fusion/fission events and anterograde and retrograde transport in neurons. Mitochondrial dynamics form an interactome that ultimately controls mitochondrial quality, quantity and metabolism. Our objective is to show that alterations in this interactome lead to point-of-no-return situations characteriz

The coherent photoproduction of J/ψ and ψ′ mesons was measured in ultra-peripheral Pb–Pb collisions at a center-of-mass energy sNN−−−√ = 5.02 TeV with the ALICE detector. Charmonia are detected in the central rapidity region for events where the hadronic interactions are strongly suppressed. The J/ψ is reconstructed using the dilepton (l+l−) and proton–antiproton decay channels, while for the ψ′ t

Jet energy scale and resolution measurements with their associated uncertainties are reported for jets using 36–81 fb−1 of proton–proton collision data with a centre-of-mass energy of s√=13 TeV collected by the ATLAS detector at the LHC. Jets are reconstructed using two different input types: topo-clusters formed from energy deposits in calorimeter cells, as well as an algorithmic combination of c

The aim of this study was to investigate whether incretins, at physiological levels, affect hepatic and/or extrahepatic insulin clearance. Hepatic and extrahepatic insulin clearance was studied in 31 double incretin receptor knockout (DIRKO) and 45 wild-type (WT) mice, which underwent an Intravenous Glucose Tolerance Test (IVGTT). A novel methodology based on mathematical modeling was designed to

This study seeks to investigate how stormwater drainage systems in coastal cities respond to climate change in terms of simultaneous sea level rise and rainfall. 7.5 years of recorded rainfall and sea level data in the city of Trelleborg in Sweden were used to generate projections of future climate events based on the emission scenario RCP8.5. Twelve scenarios were formulated to represent rain and

Background: The complex polarity of neurons requires specialized mechanisms to allocate sufficient number of mitochondria to neurites and synapses to control local calcium and ATP levels. Deficits in trafficking are directly linked to neurodegeneration. Our objective is to demonstrate that alterations of mitochondrial spatial location and metabolism are interconnected and can lead to point-of-no-r