INTRODUCTION: Calcitonin gene-related peptide (CGRP) is a neuronal messenger in intracranial sensory nerves and is considered to play a significant role in migraine pathophysiology. MATERIALS AND METHODS: We investigated the effect of the CGRP receptor antagonist, telcagepant, on CGRP-induced cranial vasodilatation in human isolated cerebral and middle meningeal arteries. We also studied the expre

Aims: The aim of this study was to find variables related to positive attitudes to physical education (PE) and strong sense of coherence (SOC) among adolescents. Methods: The study included three parts: seven physical tests; a questionnaire which included ways of living, attitudes to PE, and subjective health, the 13-question version of SOC; and information on every student's grades. The study gro

Guidance of eye-movements in image viewing is believed to be controlled by stimulus driven factors as well as viewer dependent higher level factors such as task and memory. It is currently debated to what proportions these factors contribute to gaze guidance, and also how they vary over time after image onset. Overall, the unanimity regarding these issues is surprisingly low and there are results

The isomeric diazadithiapentacenes (3) and (4) were obtained in reactions of 2-chloro-3-bromoquinoline (5) with selected sulfur reagents in various conditions. The 1,4-dithiin ring opening in diazadithiapentacene (3) led to 2,3’-diquinolinyl sulfide or (via the Smiles rearrangement stage of the S→S type) to 3,3’-diquinolinyl sulfide or to diazadithiapentacene (4) depending on reaction conditions.

The present study investigated whether the rotation rate induced by amphetamine in 6-OHDA-lesioned rats was predictive of development of l-DOPA-induced dyskinesia (LID) and success of the lesion procedure in our experimental settings. We collected data from 312 6-OHDA-lesioned rats (from different sets of experiments). Rats were subjected to the amphetamine-induced rotation test (2.5mg/kg) and chr

BACKGROUND: Animal studies suggest that the arginine vasopressin system may play a role in glucose metabolism, but data from humans are limited. METHODS AND RESULTS: We analyzed plasma copeptin (copeptin), a stable C-terminal fragment of the arginine vasopressin prohormone. Using baseline and longitudinal data from a Swedish population-based sample (n=4742; mean age, 58 years; 60% women) and multi

This small program tests some of the not-so-easily implemented features of Ada. Among the things tested are separate compilation, overloading, generics, aggregates, tasking and various real time facilities . The program can be used to get a quick assessment of the completeness of a non validated Ada compiler .