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Code Division Multiple Element Synthetic Aperture Transmission

In conventional synthetic transmit aperture imaging (STA) the image is built up from a number of low resolution images each originating from consecutive single element firings to yield a high resolution image. This lowers the frame rate and may result in motion artifacts. This paper, describes a method in which all transmitting centers can be excited at the same time and separated at the receiver

Childhood Obesity

Prevention of obesity should have the highest priority and be started as early in life as possible in high-risk families. This article covers the most promising areas of today's research aimed at finding better ways of treating obesity in the future and an overview of the treatment choices available today. The cause of obesity is genetic in approximately 40-50 percent of adults and probably to a h

C4b-binding protein (C4BP) activates B cells through the CD40 receptor

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with

Limitations of a pencil beam approach to photon dose calculations in lung tissue

A common limitation in treatment planning systems for photon dose calculation is to ignore the impact on electron transport and photon scatter from patient heterogeneities. The heterogeneity correlation is often based on scaling operations along beam rays as for the method according to Batho or the more novel approach of 1D convolutions along beam paths applied in pencil-beam-based systems. The ef

The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I

Tapasin (Tpn) is an ER chaperone that is uniquely dedicated to MHC-I biosynthesis. It binds MHC-I molecules, integrates them into peptide-loading complexes, and exerts quality control of the bound peptides; only when an "optimal peptide" is bound will the MHC-I be released and exported to the cell surface for presentation to T cells. The exact mechanisms of Tpn quality control and the criteria for

A simple score to assess mortality risk in patients waiting for coronary artery bypass grafting

Background. Independent risk factors for death in patients waiting for elective coronary artery bypass surgery have previously been identified. A prioritization where these factors are considered may potentially reduce waiting list mortality. A simple score based on the risk factors was constructed and validated. Methods. A scoring system based on risk factors in 5,864 consecutive patients operate

HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM

Some insulin-dependent diabetic (IDDM) patients develop severe forms of retinopathy. Putative risk factors such as hypertension, poor metabolic control, nephropathy and growth hormone levels do not fully explain the progress of retinopathy in these patients. It has been discussed whether there is a genetic marker, since some diabetic patients without any known predisposing risk factors develop sev

Septic arthritis as a non-surgical complication in rheumatoid arthritis: relation to disease severity and therapy

More aggressive therapy including cytotoxic drugs is increasingly used in the treatment of rheumatoid arthritis (RA), and may confer increased susceptibility to infections. Septic arthritis is one infectious complication known to be overrepresented in RA. We studied the impact of disease severity and medication in a group of nine RA patients with proven septic arthritis, excluding those occurring

Implantation of the human embryo: Research lines and models

Infertility is an increasing problem all over the world, and it has been estimated that 10 - 15% of couples in fertile age have fertility problems. Likewise induced unsafe abortion is a serious threat to women's health. Despite advances made in assisted reproduction techniques, little progress has been made in increasing the success rate during fertility treatment. This document describes a wide r

Coxsackie virus B antibodies are increased in HLA DR3-MICA5.1 positive type 1 diabetes patients in the Linkoping region of Sweden

Type 1 diabetes mellitus (T1DM) is an autoimmune disorder in which genetics and environmental factors play a role. Among the environmental factors, viruses (especially Coxsackie virus B [CBV]), and among genetic markers, human leukocyte antigen (HLA) DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8) and DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2), and major histocompatibility complex class I chain-related gene-A (M

Environmental dose rate heterogeneity of beta radiation and its implications for luminescence dating: Monte Carlo modelling and experimental validation

The recent development of rapid single sand-sized grain analyses in luminescence dating has necessitated the accurate interpretation of D-e distributions to recover a representative D-e acquired since the last bleaching event. Beta heterogeneity may adversely affect the variance and symmetry of D-e distributions and it is important to characterise this effect, both to ensure that dose distribution

Unique balanced chromosome abnormalities in treatment-related myelodysplastic syndromes and acute myeloid leukemia: Report from an international workshop

A total of 123 balanced rearrangements, including 26 occurring as a sole anomaly, not known to be recurrent in myelodysplastic syndromes (MDS) or acute myelold leukemia (AML) prior to the Workshop, were ascertained retrospectively from 104 patients with treatment-related MDS/AML (t-MDS/t-AML). Thirteen of the aberrations were reported previously in single cases and hence may be classified as recur

Influence of solvent mixing on the morphology and performance of solar cells based on polyfluorene copolymer/fullerene blends

The influence of the solvent on the morphology and performance of polymer solar cells is investigated ill devices based on blends of the polyfluorene copolymer, poly(2,7-(9,9-dioctyl-fluorene)-alt-5,5-(4',7'-di-2-thienyl-2',1',3'-ben zothiadiazole)), and [6,6]-phenyl-C-61-butyric acid methyl ester. The blends are spin-coated from chloroform or from chloroform mixed with small amounts of xylene, to

The relationship between domestic and outward foreign direct investment: The role of industry-specific effects

Previous research has been inconclusive as regards the effect of outward foreign direct investment (FDI) on domestic investments. In this article, we show that this inconclusiveness can be explained at a disaggregated level as a function of the way industries are organized. Based on a simple theoretical framework including monitoring and trade costs, we argue that a complementary relationship can

Distinguishing attacks on SOBER-t16 and t32

Two ways of mounting distinguishing attacks on two similar stream ciphers, SOBER-t16 and SOBER-t32, are proposed.. It results in distinguishing attacks faster than exhaustive key search on full SOBER-t16 and on SOBER-t32 without stuttering.

Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants

Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase. We have found that some plants and yeast also have an acyl-CoA-independent mechanism for TAG synthesis, which uses phospholipids as acyl donors and DAG as acceptor. This reaction is cataly