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A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In this large multicenter amyloid and tau positron emission tomography (PET) study (n = 1,325), we examined the

In this retrospective cohort study of 193 consecutive subjects with primary mitochondrial disease (PMD) seen at the Children's Hospital of Philadelphia Mitochondrial Medicine Frontier Program, we assessed prevalence, severity, and time of onset of sensorineural hearing loss (SNHL) for PMD cases with different genetic etiologies. Subjects were grouped by genetic diagnosis: mitochondrial DNA (mtDNA)

Aim: To establish outcomes of a priority setting partnership between participants with diabetes mellitus and clinicians to identify the top 10 research priorities for preventing and treating diabetic foot ulcers (DFUs). Methods: Due to the COVID-19 pandemic, the James Lind Alliance Priority Setting Partnership process was adapted into a digital format which involved a pilot survey to identify unde

Perturbation of soil microbial communities by rising temperatures could have important consequences for biodiversity and future climate, particularly in tropical forests where high biological diversity coincides with a vast store of soil carbon. We carried out a 2-year in situ soil warming experiment in a tropical forest in Panama and found large changes in the soil microbial community and its gro

BackgroundAssessing pain in the intensive care unit (ICU) is challenging. Due to intubation and sedation, communication can be limited. International guidelines recommend assessing pain with instruments based on behavioral parameters when critically ill patients are unable to self-report their pain level. One of the recommended instruments, the Behavioral Pain Scale (BPS), has shown good validity

AimTo explore the patients´ experiences of pain when being cared for in the intensive care.DesignAn exploratory, qualitative design was chosen.MethodInterviews were performed with patients (October 2015–March 2017) within a week of post-intensive care (N = 16). Thematic analysis was used as method for analysis.ResultsThe findings generated two themes – a lack of control and to struggle for control

ObjectivesThe Behavioural Pain Scale has previously been translated into Swedish and psychometrically tested. One of the domains- ‘compliance with ventilation’- did not show equally as good psychometric proprieties as the other domains, which led to the question whether a development of that domain would be beneficial. This study aimed to develop the domain of ‘breathing pattern’ in the Swedish ve

This paper documents regional population changes in Sweden since 1860 and investigates how these changes link to regional economic development (regional GDP). We combine long-term decade population data for the historical counties (1860–2020) with detailed annual population observations for municipalities (1968–2021). As industrialization picked up speed, this benefited regions all around the coun

Experimentation has become one of the prevailing modes of governing the transition toward sustainable practices in urban environments. The spatial variation of urban sustainability transition has been attributed to a variety of conditions erected at different spatial scales. What remains less well-understood is how spatial situatedness shapes agency in urban experiments and the shapes agency can t

This chapter explores the role, success and failures of spatial planning in shaping African cities and its influence on livelihoods. To date, planning in Africa has largely failed to address the needs and livelihoods of the poor and struggled to address wider issues such as spatial and economic inclusion, health inequalities, future pandemics and climate change. Planning for sustainable livelihood

Short-term memory is implicated in a range of cognitive abilities and is critical for understanding primate cognitive evolution. To investigate the effects of phylogeny, ecology and sociality on short-term memory ability, we tested 421 non-human primates across 41 species in a pre-registered, experimental delayed-response task. Our results confirm previous findings that longer delays decrease memo

The objective of this paper is to outline and discuss the key elements of an EU industrial development policy consistent with the Paris Agreement. We also assess the current EU Industrial Strategy proposal against these elements. The “well below 2 °C” target sets a clear limit for future global greenhouse gas emissions and thus strict boundaries for the development of future material demand, indus

PurposeThis study explores Greek and Swedish consumers' attitude towards organic food consumption in order to demonstrate possible differences that can be identified based on health and ecological consciousness beliefs rather than demographic factors. The examination of an emerging and a more mature market allow the authors to provide more targeted marketing strategies that possibly increase organ

Taking stance towards any topic, event or idea is a common phenomenon on Twitter and social media in general. Twitter users express their opinions about different matters and assess other people’s opinions in various discursive ways. The identification and analysis of the linguistic ways that people use to take different stances leads to a better understanding of the language and user behaviour on

The atomistic structure of calcium-silicate-hydrate (C-S-H) has been studied by applying force field simulations and quantum mechanical methods. Large number of crystallographically equivalent structures were used to account for the disordered nature of C-S-H. An extensive set of periodic structures of C-S-H (with a variation of chemical composition) has been generated and optimised. Special att

I länder med fria val finns demokratiska spelregler som gör att systemet i viss utsträckning redan är förutbestämt. Befolkningen har till exempel på förhand ett begränsat antal partier att välja mellan. Det finns också formella problem, som att fördelningen av mandat över ett land faktiskt kan bestämma utgången redan innan medborgarna gått till vallokalerna. I Demokratiparadoxen fördjupar sig prof