Purpose: To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to assist physicians and allied health care professionals in general and specialist practise throughout the world. Methods: Sixteen experts from four medical disciplines (primary care, rheumatology, orth

α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein physiology is still difficult to clear up due to its interaction with multiple partners and its involvement in a pletora of neuronal functions. Here, we looked at the remarkab

Magnetic and magneto-transport properties of thin layers of the (Ga,Mn)(Bi,As) quaternary dilute magnetic semiconductor grown by the low-temperature molecular-beam epitaxy technique on GaAs substrates have been investigated. Ferromagnetic Curie temperature and magneto-crystalline anisotropy of the layers have been examined by using magneto-optical Kerr effect magnetometry and low-temperature magne

Background: Bone loss at peripheral sites in the elderly is mainly cortical and involves increased cortical porosity. However, an association between bone loss at these sites and 25-hydroxyvitamin D has not been reported. Objective: To investigate the association between serum levels of 25-hydroxyvitamin D, bone microstructure and areal bone mineral density (BMD) in elderly men. Methods: A populat

We consider a multiple-input multiple-output (MIMO) channel with inter-symbol interference (ISI) where signal detection is highly complex due to the large signal state-space dimensionality. A common strategy is to apply a front-end filter (FEF) to eliminate the ISI dimension (i.e. full ISI equalization). This FEF is then followed by a frequency non-selective MIMO detector. However, another, much l

Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands (mainly the salivary and lacrimal glands) and results in the severe dryness of mucosal surfaces, principally in the mouth and eyes. This disease predominantly affects middle-Aged women, but can also be observed in children, men and the elderly. The clinical presentation of SjS is heterogeneous and ca

This research discusses the importance of a photograph of an accused war criminal, Abdul Kader Molla, during the period immediately before the emergence of the Shahbag movement in Bangladesh. The image captures Kader Molla flashing a V sign, and it was taken in the moments after he had been sentenced to life imprisonment by the International Crimes Tribunal in Bangladesh in 2013. After Kader Molla

Familial aggregation (clustering) of venous thromboembolism (VTE) is the clustering of VTE within a family. Though several genes, such as antithrombin, protein C, protein S, factor V, and prothrombin are associated with the familial clustering of VTE, these loci only partially explain the familial aggregation of VTE. The epidemiology of the familial aggregation of VTE exhibits typical characterist

Fires in enclosures equipped with mechanical ventilation remain one of the key issues for fire safety assessment in multifamily homes and industries. Therefore, a wide variation of methods for preventing smoke spread through the ventilation system exist and are applied, in performance-based designs. Through the use of the heating, ventilation and air conditioning (HVAC) model in the fire dynamics

The current fire testing and classification system and corresponding tests is mainly based on prescriptive building fire codes. This has certain limitations resulting in restricting the possible use of these tests for performance-based design within fire safety engineering (FSE). It also restricts innovation and cost-efficiency for companies supplying materials/components for buildings and transpo

Eye-tracking research in infants and older children has gained a lot of momentum over the last decades. Although eye-tracking research in these participant groups has become easier with the advance of the remote eye-tracker, this often comes at the cost of poorer data quality than in research with well-trained adults (Hessels, Andersson, Hooge, Nyström, & Kemner Infancy, 20, 601-633, 2015; Was

Background: High amounts of alkali in the fuel, such as potassium and sodium in combination with high amounts of chlorine increase the chances of high-temperature corrosion, deposit growth and slagging and fouling. These risks need to be reduced to avoid losses in revenue due to unplanned stops and costs related to increased maintenance. Aims:This research targets the development of a new cell to

Within the insect order Lepidoptera (moths and butterflies), the so-called nonditrysian superfamilies are mostly species-poor but highly divergent, offering numerous synapomorphies and strong morphological evidence for deep divergences. Uncertainties remain, however, and tests of the widely accepted morphological framework using other evidence are desirable. The goal of this paper is to test previ

The Acanthopteroctetidae are one of the first-originated family-group lineages within "tongue moths" (Lepidoptera-Glossata). The purpose of this study is to provide a comprehensive account (based on whole mount preparations, serial sections, and Scanning electron microscopy) of the cephalic structure of an adult exemplar of the family, to supplement the sparse available information. Notable plesio

We review and illustrate the four species of Choreutidae recorded from Madeira - Anthophila threnodes (Walsingham), A. fabriciana (Linnaeus), Choreutis nemorana (Hubner), and Tebenna micalis (Mann) - and describe and illustrate for the first time the male of A. threnodes, as well as the biology of this Madeiran endemic. We provide brief notes on each of the species and give short diagnoses for cor