Sökresultat

Filtyp

Din sökning på "*" gav 531027 sökträffar

Comparison of the Regenerative Potential for Lung Tissue of Mesenchymal Stromal Cells from Different Sources/Locations Within the Body

Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proTo date, bone marrow-derived mesenchymal stromal cells (MSCs) have been considered the golden standard among MSC cell-based therapies. However, the harvesting of bone marrow is a highly invasive procedure and the number of MSCs isolated is low, and it declines with increasing age. MSCs with immune-regulatory and regenerative properties can be isolated from many different tissues; however, bone mar

Crisis and Public Support for the Euro, 1990–2014

This article analyses the evolution of public support for the single European currency, the euro, from 1990 to 2014 for a 12-country sample of the euro area (EA-12), focusing on the most recent period of the financial and sovereign debt crisis, starting in 2008. We find that citizens’ support for the euro on average was marginally reduced during the first six years of the crisis, and that support

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we h

Key knowledge gaps to achieve global sustainability goals

Regional and global assessments periodically update what we know, and highlight what remains to be known, about the linkages between people and nature that both define and depend upon the state of the environment. To guide research that better informs policy and practice, we systematically synthesize knowledge gaps from recent assessments of four regions of the globe and three key themes by the In

Vulnerable agency: fat, bodies and their making among youth in a Brazilian favela

Contemporary social and cultural conditions in Brazil, together with technological developments and social media have enabled more young people of the favela to participate in different spheres of public life. These social and cultural changes have brought diversified new images of what it means to be an embodied subject. In this article, I explore the ways in which the body holds a seemingly para

War and Algorithm

New military technologies are animated by fantasies of perfect knowledge, lawfulness, and vision that contrast sharply with the very real limits of human understanding, law, and vision. 'War and Algorithm' look at the increasing power of algorithms in these emerging forms of warfare from the perspectives of critical theory, philosophy, legal studies, and visual studies. Together, the contributions

Neural correlates of second language acquisition of tone-grammar associations

Native speakers of Swedish use tones on stems to predict which suffix is to follow. This is seen behaviorally in reduced response times for matching tone-suffix pairs. Neurophysiologically, online prediction is reflected in the event-related potential (ERP) component pre-activation negativity (PrAN) occurring for tones with a higher predictive value. Invalid suffixes relative to the tone produce a

Comparison of Cu salts and commercial Cu based fungicides on toxicity towards microorganisms in soil

Microbial responses to Cu pollution as a function of Cu sources (Cu salts and commercial Cu fungicides) were assessed in a soil using basal soil respiration, and bacterial and fungal community growth, as endpoints. The soil was amended with different concentrations (0–32 mmol Cu kg−1) of Cu nitrate, Cu sulfate, Bordeaux mixture and 3 types of Cu oxychloride. Cu salts decreased soil pH, while this

Favorable Pharmacokinetic Characteristics of Extended-Half-Life Recombinant Factor VIII BAY 94-9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach

Background: Prophylaxis with factor VIII (FVIII) should be individualized based on patient characteristics, including FVIII pharmacokinetics. Population pharmacokinetic (popPK) modeling simplifies pharmacokinetic studies by obviating the need for multiple samples. Objective: The objective of this study was to characterize the pharmacokinetics and inter-individual variability (IIV) of BAY 94-9027 i

Disentangling the Arcturus stream

Context. The Arcturus stream is an over-density of stars in velocity space and its origin has been much debated recently without any clear conclusion. The (classical) dissolved open cluster origin is essentially refuted; instead the discussions try to distinguish between an accretion, a resonant, or an external-perturbation origin for the stream. As kinematic structures are observational footprint

On constructions of Lie (super) algebras and (, Î)-Freudenthal-Kantor triple systems defined by bilinear forms

In this work, we discuss a classification of (,Î)-Freudenthal-Kantor triple systems defined by bilinear forms and give all examples of such triple systems. From these results, we may see a construction of some simple Lie algebras or superalgebras associated with their Freudenthal-Kantor triple systems. We also show that we can associate a complex structure into these (,Î)-Freudenthal-Kantor triple

Soil Microbial Responses to 28 Years of Nutrient Fertilization in a Subarctic Heath

Arctic and subarctic soils are typically characterized by low nitrogen (N) availability, suggesting N-limitation of plants and soil microorganisms. Climate warming will stimulate the decomposition of organic matter, resulting in an increase in soil nutrient availability. However, it remains unclear how soil microorganisms in N-limited soils will respond, as the direct effect of inorganic N additio

Artificial Intelligence and automated decision-making in healthcare

AI is expected to be a driver for improved standards of health, reduced costs, decentralized care and facilitated access to healthcare. Its successful implementation depends on technology factors and industrial investments in AI innovation, but also conditional to trust and acceptance by patients, medical staff and healthcare authorities. AI will inevitably change the nature of health care innovat

An Interview Study of Professional Carers’ Experiences of Supporting Patient Participation in a Maximum Security Forensic Psychiatric Setting

Patient participation in forensic psychiatric settings seems to be complex by nature, and previous studies show that patients rate their participation as lower in this context compared to general psychiatric contexts. Studies on caregivers’ perspective could provide a clearer picture of the components and possibilities of patient participation in forensic psychiatry. The aim of the study is to des

A C-terminal peptide of TFPI-1 facilitates cytosolic delivery of nucleic acid cargo into mammalian cells

Efficient intracellular nucleic acid delivery into mammalian cells remains a long-standing challenge owing to poor cell permeability and uptake of naked nucleic acids across the cell membrane and limited cargo stability. Conventional delivery methods have several drawbacks, such as cytotoxicity, limited cell-type applicability, low efficiency, hindrances that limit the potential of oligonucleotide

Ectomycorrhizal utilization of different phosphorus sources in a glacier forefront in the Italian Alps

Aims: In deglaciated surfaces, lithology influences habitat development. In particular, serpentinite inhibits soil evolution and plant colonization because of insufficient phosphorus (P) content, among other stressful properties. In nutrient-poor environments, ectomycorrhizal fungi (EMF) play a key role exploring the soil for P beyond the rhizosphere. In this study, we followed the role of EMF in