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Electrokinetic wall effect mechanisms and applications

Under the application of longitudinal electric fields in microchannels, microparticles experience lift forces that push them away from the channel walls and affect their trajectories. At high frequencies (>100KHz) the dielectrophoretic forces dominate and are well understood but at lower frequencies there is little agreement as to the exact nature of the forces, how they are generated and how they

DNA concentration wave formation in pillar arrays

High throughput in particle and molecular sorting schemes is an important performance indicator and can be realized through increased volumetric processing rates or increased concentrations. Here we investigate the effect of increased concentration of high-molecular weight DNA in micropillar arrays for deterministic lateral displacement (DLD). We find that the array imposes regular fluctuations in

Stressin’ and slicin’ : stress-induced tRNA fragmentation codon-adapts translation to repress cell growth

Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adapti

Compensation and Socio-Economic Status of Borrowers in Foreclosure : Evidence from Swedish Micro-data

Proper compensation during foreclosure is essential to any effort to protect borrowers as consumers. However, the effectiveness of consumer protection and other safety nets during foreclosure has been debated within academia. This study contributes to this debate by exploring socio-economic group differences related to the compensatory potential of foreclosure proceedings. It employs micro-level d

Solving Hard Problems by Protein Folding?

Inspired by the NP-hardness of string folding problems modeling the natural process of protein folding, we discuss the idea of solving instances of NP-hard problems (e.g., string folding problems) of moderate size by letting artificially assembled proteins to fold. The accuracy with which one can combinatorially model the protein folding process, e.g., by string folding, as well as the precision w

Nanostructures for probing and transfecting living cells

Nanowires and nanotubes are very promising tools for biological applications. Their small dimensions, which are on the same length scale as many cell components, make them an ideal tool to probe and stimulate cells with minimal perturbation. Here, we present a review of our work towards using nanowires and nanotubes for biomedical applications, such as neural implant, mechanosensing, and cell tran

Worked goose radii from medieval England : What were they used for?

This paper examines an artefact type of unknown function, found in several places across medieval England. These artefacts are mostly made from goose radii, but other species, such as chicken and hare, are also known. The worked radii have often been interpreted as being related to writing, but a closer examination suggests that they are more likely to be awls.

Gender Stereotypes in Student Evaluations of Teaching

This paper tests how gender stereotypes may result in biased student evaluations of teaching (SET). We thereby contribute to an ongoing discussion about the validity and use of SET in academia. According to social psychological theory, gender biases in SET may occur because of a lack of fit between gender stereotypes, and the professional roles individuals engage in. A lack of fit often leads to m

The role of platelets in sepsis

A State of the Art lecture titled “The role of platelets in sepsis” was presented at the ISTH congress in 2020. Sepsis is a life-threatening organ dysfunction caused by a dysregulated and multifaceted host response to infection. Platelets play a significant role in the coordinated immune response to infection and therefore in the inflammation and coagulation dysfunction that contributes to organ d

Accuracy of NIH Stroke Scale for diagnosing aphasia

Objectives: The National Institutes of Health Stroke Scale (NIHSS) has not been validated to diagnose aphasia in the stroke population. We therefore examined the diagnostic accuracy of NIHSS for detecting aphasia in acute ischemic stroke. Methods: Consecutive patients with acute first-ever ischemic stroke were included prospectively in Lund Stroke Register Study at Skåne University Hospital, Swede

Military Wages and Coup d’État in Spain (1850-1915): the Use of Public Spending as a Coup-Proofing Strategty : The USE of PUBLIC SPENDING AS A COUP-PROOFING STRATEGY

In 1833-1874, Spain suffered 0.7 coups per year. By contrast, the Restoration (1874-1923) saw the eradication of successful coups. This can be partially attributed to the turno pacífico, which allowed the main political parties to alternate in office without dragging the military into politics. We suggest, however, that the reduction in coup risk was also associated with a conscious budget policy.

Screening Environmental Impact Reduction Enabled by Brass Reclamation through Hot Forging Operations

The traditional method for recycling brass chips is to send the scrap back to the material manufacturer for re-melting. Alternatively, brass chips can be reclaimed through hot forging operations at the production site. As an initial screening of the environmental impact of this novel reclamation method, the impacts of this new method was compared to conventional brass production (including recycli

Widespread skeptic attitudes among people with epilepsy toward generic antiseizure drugs – A Swedish survey study

Purpose: To explore associations between the characteristics of people with epilepsy (PWE) and their attitudes toward generic substitution of antiseizure drugs (ASDs) in epilepsy. Methods: This was a cross-sectional survey study directed at adults with epilepsy using selected brand drugs: Keppra®, Lamictal®, Lyrica® or Topimax®. Symptoms of anxiety and depression, sense of self-efficacy, and belie

Exit, voice, loyalty, and … disobedience : When a CEO opposes his principal

Research Question/Issue: On the basis of a dynamic interrelation between the assumptions of agency theory and stewardship theory, this study seeks to make sense of disobedience at the highest corporate level. Departing from a processual view in order to better understand how loyalty plays a critical role in the relationships between a CEO and his/her principal, we propose a conceptualization of th

Financial Regulation Debates in Hard Times: A Comparative Analysis of Insider and Outsider Pressure during the Global Financial Crisis

This article analyses the nature of policy debates on financial regulation during the onset of the Global Financial Crisis (GFC) by considering three elements that shape them: the salience of the debate, the actors that dominate the debate, and the degree of anti-status quo pressure. Theoretically, it contributes to Culpepper’s quiet/noisy politics framework by clarifying its multidimensionality a

Photoexcitation dynamics in electrochemically charged CdSe quantum dots : From hot carrier cooling to auger recombination of negative trions

Fulfilling the potential of colloidal semiconductor quantum dots (QDs) in electrically driven applications remains a challenge largely since operation of such devices involves charged QDs with drastically different photophysical properties compared to their well-studied neutral counterparts. In this work, the full picture of excited state dynamics in charged CdSe QDs at various time scales has bee

Housing adaptations and housing accessibility problems among older adults with long-standing spinal cord injury

Introduction: Adults with spinal cord injuries are living longer than previously, and a majority are living in ordinary housing in the community. Housing accessibility is important for maintaining independent occupational performance for this population, but knowledge in this area is insufficient. We investigated housing adaptations and current accessibility problems among older adults with long-s

Rapid multinodal acoustic trapping of extracellular vesicles for downstream mass spectrometry analysis

We report the use of multinodal acoustic trapping for high throughput and high capacity capturing of EV's (extracellular vesicles) for quantitative mass spectrometry analysis. The multinode trapping unit was shown to isolate sufficient amount of EV's from dilute biological samples (urine and cell culture supernatant) at flow rates of 500 ul/min within minutes, enabling EV proteome profiling. This

Medial temporal atrophy in preclinical dementia : Visual and automated assessment during six year follow-up

Medial temporal lobe (MTL) atrophy is an important morphological marker of many dementias and is closely related to cognitive decline. In this study we aimed to characterize longitudinal progression of MTL atrophy in 93 individuals with subjective cognitive decline and mild cognitive impairment followed up over six years, and to assess if clinical rating scales are able to detect these changes. Al