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Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-se
Most in vitro reporter gene assays used to assess estrogenic contamination are based on human estrogen receptor α (hERα) activation. However, fish bioassays can have distinct response to estrogenic chemicals and mixtures, questioning the relevance of human-based bioassays for assessing risk to this species. In this study, zebrafish liver cells stably expressing zebrafish ERβ2 (ZELHβ2) and human br
The main sources of non-exhaust particles around metro systems are the wear from wheel-rail contact, brake contact and the contact between mechanical parts in electric power systems. In order to predict the PM10 levels on underground metro platforms, the relation among time, train frequency and PM10 level should be investigated. Two types of particle emission models have previously been published
Background and aims Persistent neck pain is common and can be detrimental to the health of those who are affected. This is particularly common after neck trauma, where it poses a challenge to health care providers. In this paper, we present the design and results of a study aimed primarily at assessing the feasibility of a supervised exercise intervention for patients with persistent neck pain aft
Background: Precarious employment is a risk factor for poor mental health, particularly among young adults. Knowledge about how young people maintain their mental health while in a precarious employment situation is scarce. The aim of the study was to explore the meaning of precarious employment for young adults in Sweden and their strategies for maintaining good mental health. Methods: In-depth i
Background: Arginine vasopressin has complex actions in critically ill patients, involving vasoregulatory status, plasma volume, and cortisol levels. Copeptin, a surrogate marker for arginine vasopressin, has shown promising prognostic features in small observational studies and is used clinically for early rule out of acute coronary syndrome. The objective of this study was to explore the associa
This paper outlines promising avenues for empirical research on quantified control in healthcare work. A review of key insights from accounting, organization studies, and the emergent sociology of quantification indicates that numbers are productive as well as deceptive and seductive, that they enable control but can be evaded, and that they typically have unintended effects. It remains to be furt
In thin notched sheets under tensile loading, wrinkling appears on the sheet surface, specifically around the cracked area. This is due to local buckling and compression stresses near the crack surfaces. This study aims to numerically study the buckling behavior of a thin sheet with a central crack under tension. A numerical model of a notched sheet under tensile loading is developed using the fin
In this paper, we look at the terrain of Malcolm X's "failed rhetoric" as producing an apocalyptic refusal of world, and world making. This refusal finds its intensity from a distinct gnostic calculus, driving Malcolm X's political theology of names and worlds, seen in his oratory from the years 1962–1964. First, Malcolm X's nominal history is discussed in relation to the violence of naming and po
Creative AI (notably GANs and VAEs) can generate convincing fakes of video footage, pictures, graphics, etc. In order to conceptualize the societal role of creative AI a new conceptual toolbox is needed. The paper provides metaphors and concepts for understanding the functioning of creative AI. It shows how the role of creative AI in relation to FAT ideals can be enriched by a dynamic and construc
Berättigad kritik mot rättsväsendet eller okontrollerad pöbeljustis? I kölvattnet av #metoo-rörelsen kvarstår spänningen mellan de sociala mediernas virala rätt och rättsväsendets formella rätt. Rättsvetaren Linnea Wegerstad tar sig här an kärnan i den senaste tidens fem #metoo-relaterade förtalsåtal: konflikten mellan rätten att berätta om sexuellt våld och rätten att inte bli föremål för ryktess
A key enabler for Industry 4.0 is Fifth Generation Wireless Specifications (5G), within which network slicing is a promising technique to ensure customized quality of service for specific end-user groups in industrial scenarios. Massive Multiple Input Multiple Output (MIMO) plays a significant role in 5G but network slicing for massive MIMO has not yet been addressed. In this paper, we propose a n
This thesis is an empirical and theoretical investigation of choice blindness, in particular in the domain of political attitudes. Choice blindness is a cognitive phenomenon in which people do not notice dramatic mismatches between what they choose and what they get while still offering seemingly introspective arguments to explain their (putative) choice. In four papers, it is demonstrated that th
Thirty-seven sera positive for anti-GBM antibodies (antibodies against the ‘Goodpasture antigen’ = NCI-domain of collagen IV) in routine analysis were studied for antigen restriction and IgG subclasses. Four different polypeptides, the four α-chains (α1, α2, α3 and α4) of human collagen IV NCI, were used as coating in ELISA assays. Autoantibodies were detected with monoclonal antibodies towards hu
Sera that had been positive in routine ELISA for ANCA were studied retrospectively for the IgG subclass distribution of these autoantibodies. An ELISA previously developed for measurement of IgG sub classes of anti-GBM antibodies was modified for this purpose. Of a total of 247 sera, 114 were found to be positive in at least one of the assays for IgG subclasses of anti proteinase 3, 72 of these pa
We studied IgG subclass distribution of ANCA in 247 patients with ELISA. We used monoclonal subclass specific antibodies and purified MPO and proteinase 3 as antigen. We found that IgG1 and IgG4 yield high values in both groups. We also found that high IgG2 titers were rare among the anti-proteinase 3 positive, while it was common among anti-MPO sera. In the assays for IgG3 the situation was the o
Abstract. Objectives. To ascertain whether a relationship exists between the PiZ alpha1‐antitrypsin (α1AT) variant and antineutrophil cytoplasm antibodies (ANCA)‐positive vasculitis in a large group of Swedish patients, and whether analysis for the presence of the PiZ variant might be useful for diagnostic or prognostic purposes. Design. Retrospective cross‐sectional study. Setting. The Departmen
Rapidly progressive glomerulonephritis with or without other signs of systemic vasculitis is often accompanied by antibodies to myeloperoxidase. Such antibodies normally produce a perinuclear pattern on ethanol-fixed neutrophils (perinuclear anti-neutrophil cytoplasm antibodies (P-ANCA)) at indirect immunofluorescence. We report here sera from three patients that are anti-myeloperoxidase-positive
