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Biologics beyond TNF-α inhibitors and the effect of targeting the homologues TL1A-DR3 pathway in chronic inflammatory disorders

A number of anti-tumor necrosis factor alpha (TNF-α) biologics have been developed in recent years, such as adalimumab, etanercept, and infliximab for the treatment of chronic inflammatory disorders like rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis and several other novel drugs that target TNF-α signaling are still being developed. Indeed, blockade of this pathway see

Update in antibiotic therapy in intensive care unit : report from the 2019 Nîmes International Symposium

The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues

How Companies Use OSS Tools Ecosystems for Open Innovation

Moving toward the open innovation (OI) model requires multifaceted transformations within companies. It often involves giving away the tools for product development or sharing future product directions with open tools ecosystems. Moving from the traditional closed innovation model toward an OI model for software development tools shows the potential to increase software development competence and

Scaling limits of random normal matrix processes at singular boundary points

We introduce a method for taking microscopic limits of normal matrix ensembles and apply it to study the behaviour near certain types of singular points on the boundary of the droplet. Our investigation includes ensembles without restrictions near the boundary, as well as hard edge ensembles, where the eigenvalues are confined to the droplet. We establish in both cases existence of new types of de

Searches for lepton-flavour-violating decays of the Higgs boson in s=13 TeV pp collisions with the ATLAS detector

This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H→eτ and H→μτ, performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy s=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model proce

Inequalities in child immunization coverage in Ghana : evidence from a decomposition analysis

Childhood vaccination has been promoted as a global intervention aimed at improving child survival and health, through the reduction of vaccine preventable deaths. However, there exist significant inequalities in achieving universal coverage of child vaccination among and within countries. In this paper, we examine rural-urban inequalities in child immunizations in Ghana. Using data from the recen

FoxB, a new and highly conserved key factor in arthropod dorsal-ventral (DV) limb patterning

Forkhead box (Fox) transcription factors evolved early in animal evolution and represent important components of conserved gene regulatory networks (GRNs) during animal development. Most of the researches concerning Fox genes, however, are on vertebrates and only a relatively low number of studies investigate Fox gene function in invertebrates. In addition to this shortcoming, the focus of attenti

Coping with Chronic Warfare : The Athenian Experience

In Classical Athens, being at war was much more common than peace. The military expenditures were correspondingly large. The real enigmatic issue, however, is not financial but where they found the manpower needed for this policy. The number of warships (triremes) was so great that there is no way that the citizen could have dominated in the crews. The main source is likely the non-citizen, free p

Hematopoietic stem cell-targeted neonatal gene therapy with a clinically applicable lentiviral vector corrects osteopetrosis in oc/oc Mice

Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by nonfunctional osteoclasts. Approximately 50% of the patients have mutations in the TCIRG1 gene, encoding for a subunit of the osteoclast proton pump. Gene therapy represents a potential alternative treatment to allogeneic stem cell transplantation for IMO. The oc/oc mouse is a model of IMO characterized by

Crack Perpendicular to and terminating at a bi-material interface

By using dislocation simulation approach, the basic equation was formulated. A novel expansion method was proposed for solving the problem. The complete solution to the problem, including the explicit formulae for the T stresses ahead of the crack tip and the stress intensity factors were presented. The stress field characteristics were analysed in detail. It is found that the normal stresses ahea

Insights from intralocus tactical conflict : adaptive states, interactions with ecology and population divergence

Alternative reproductive tactics (ARTs) have improved our understanding of the evolution of adaptive variation; for instance, their study has led us to understand that the best phenotype (e.g. large and flashy) for a tactic that uses one mating behavior (e.g. court females) is often not the best phenotype (e.g. small and inconspicuous) for a tactic that uses a different mating behavior (e.g. chase

Analysis of Mortality among Neonates and Children with Spina Bifida : An International Registry-Based Study, 2001-2012

Background: Medical advancements have resulted in better survival and life expectancy among those with spina bifida, but a significantly increased risk of perinatal and postnatal mortality for individuals with spina bifida remains. Objectives: To examine stillbirth and infant and child mortality among those affected by spina bifida using data from multiple countries. Methods: We conducted an obser

Predominant mechanisms for the removal of nickel metal ion from aqueous solution using cement kiln dust

The experimental methodology achieved in the present study signified that the adsorption and precipitation were main mechanisms occurred together in the removal of nickel from aqueous solution by sorption using cement kiln dust (CKD) byproduct as sorbent. Finding the contribution of each mechanism in the removal process and derivation an analytical model for finding the portion of precipitation we

Impact of a national guideline on use of knee arthroscopy : An interrupted time-series analysis

OBJECTIVE: To assess the impact of the Swedish health authority recommendation against the use of knee arthroscopy in patients aged ≥40 years with knee osteoarthritis (OA).DESIGN: Interrupted time series analysis.SETTING: Public health care in Skåne region.PARTICIPANTS: Patients aged ≥40 years who underwent knee arthroscopy from January 2010 to December 2015.INTERVENTION(S): National guideline's r

Higher CSF Tau Levels Are Related to Hippocampal Hyperactivity and Object Mnemonic Discrimination in Older Adults

Mnemonic discrimination, the ability to distinguish similar events in memory, relies on subregions in the human medial temporal lobes (MTLs). Tau pathology is frequently found within the MTL of older adults and therefore likely to affect mnemonic discrimination, even in healthy older individuals. The MTL subregions that are known to be affected early by tau pathology, the perirhinal-transentorhina

Immigrant enclaves and risk of drug involvement among asylum-seeking immigrants in Sweden : A quasi-experimental study

Background: Sweden is a major host nation for asylum-seeking immigrants, and residential placement of these immigrants is an important policy concern. This quasi-experimental study estimated of the impact of being placed into an “immigrant enclave” on risk of officially-recognized drug involvement (ORDI) among asylum-seeking immigrants over a 15-year period. Methods: All data come from Swedish reg