Introduction: Cerebrospinal fluid (CSF) biomarkers have the potential to improve the diagnostic accuracy of Alzheimer's disease, yet there is a lack of harmonized preanalytical CSF handling protocols. Methods: This systematic review summarizes the current literature on the influence of preanalytical variables on CSF biomarker concentration. We evaluated the evidence for three core CSF biomarkers:

This study presents a new method for estimation and imaging of the area at risk (AaR) in myocardial infarction (MI). The values of the ST-segment deviations of 12-lead ECG signal were used as input parameters. Based on DECARTO model, the spherical surface was chosen as a reference surface to approximate the ventricular wall. On this surface, the spatial ST vector was projected. The center of AaR w

Objective: Patient-provider relationships with primary care and need for hospitalisations are related within the complex networks comprising healthcare. Our objective was to analyse mean days hospitalised, using registration status (active or passive listing) with a provider and number of consultations as proxies of patient-provider relationships with primary care, adjusting for morbidity burden,

Energy intensive industries are one of the fields in which strong increases of energy efficiency and deep decarbonisation strategies are particularly challenging. Although European energy intensive industries have already achieved significant energy and greenhouse gas reductions in the past, much remains to be done to make a significant contribution to achieving European as well as national climat

Natural gas makes an increasing contribution to the European Union's energy supply. Due to its efficiency and low level of combustion emissions this reduces greenhouse gas emissions compared to the use of other fossil fuels. However, being itself a potent greenhouse gas, a high level of direct losses of natural gas in its process chain could neutralise these advantages. Which effect will finally p

The Russian natural gas industry is the world's largest producer and transporter of natural gas. This paper aims to characterize the methane emissions from Russian natural gas transmission operations, to explain projects to reduce these emissions, and to characterize the role of emissions reduction within the context of current GHG policy. It draws on the most recent independent measurements at al

We report a unique case of "aleukemic" skin chloroma located at the place of previous head injury. Chloroma presented as a local livid papulous skin infiltration (5x3cm), whilst physical examination and patient's complete blood counts were normal. Chloroma spontaneously disappeared. One month later, a diagnosis of acute myeloid leukemia was made. We discussed different pathogenetic mechanisms of t

At present, air conditioning (AC) is the most effective means for the cooling of indoor space. However, its increased global use is problematic for various reasons. This is a correspondence to the supplementary opinion provided by Dr. Bin Yang, Dr. Stefano Schiavon, and Dr. Faming Wang to our paper titled “Challenges of using air conditioning in an increasingly hot climate.” The paper explored the

The article is an attempt to identify some common themes in a body of work while at the same time regarding Sweden as especially conducive to pessimism regarding the decline in the moral economy of the world. Ever since the collapse of the Soviet Union and the newfound independence of the Baltic states of Estonia, Latvia and Lithuania, Swedish filmmakers have repeatedly crossed the Baltic in searc

The blowout limits of methane/air non-premixed swirl-stabilized flames were measured with and without quarl. The addition of a quarl significantly enhances the flame blowout limits. The transition from attached flame to blowout was mapped. To explore the role of the quarl, a series of OH-PLIF/PIV experiments, coupled with large eddy simulations (LES) using a transported probability density functio

Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic

Benthic macroinvertebrates are part of a complex network of interactions. The spatial and temporal scales of the processes that form the basis for these interactions have traditionally restricted their empirical investigation. The first chapter of the manuscript attempts a review of the modelling tools that have been employed for the study of the marine benthos.The implementation of a mechanistic

Inflammation has been implicated in the pathogenesis of Parkinson’s disease (PD). We here investigate levels of inflammatory biomarkers in cerebrospinal fluid (CSF) in PD and atypical parkinsonian disorders (APD) compared with neurologically healthy controls. We included 131 patients with PD and 27 PD with dementia (PDD), 24 with multiple system atrophy (MSA), 14 with progressive supranuclear pals

Hydrophobic pervaporation has been shown to be a promising, alternative process for the recovery of volatile organic components from their aqueous solutions, such as the recovery of aroma compounds in the food industry. Until now most of the research on the influence of operating parameters on aroma recovery by pervaporation has been conducted on the laboratory scale. The number of studies dealing