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Development of an influenza virus protein microarray to measure the humoral response to influenza virus infection in mallards

Avian influenza viruses pose a serious zoonotic threat, in part because current seasonal influenza virus vaccines only offer strain-specific protection, instead of heterosubtypic or universal protection against influenza virus infection. Understanding the humoral response to vaccination and natural infection in the broadest context possible is important to developing defenses against influenza zoo

In vivo mallard experiments indicate that zanamivir has less potential for environmental influenza a virus resistance development than oseltamivir

Neuraminidase inhibitors are a cornerstone of influenza pandemic preparedness before vaccines can be mass-produced and thus a neuraminidase inhibitor-resistant pandemic is a serious threat to public health. Earlier work has demonstrated the potential for development and persistence of oseltamivir resistance in influenza A viruses exposed to environmentally relevant water concentrations of the drug

Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation

Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Result

Ubiquity of Beutler-Fano profiles : From scattering to dissipative processes

Fano models - consisting of a Hamiltonian with a discrete-continuous spectrum - are one of the basic toy models in spectroscopy. They have been successful in explaining the line shape of experiments in atomic physics and condensed matter. These models, however, have largely been beyond the scope of dissipative dynamics, with only a handful of works considering the effect of a thermal bath. Yet in

Measurement of long-range multiparticle azimuthal correlations with the subevent cumulant method in pp and p +Pb collisions with the ATLAS detector at the CERN Large Hadron Collider

A detailed study of multiparticle azimuthal correlations is presented using pp data at s=5.02 and 13 TeV, and p+Pb data at sNN=5.02 TeV, recorded with the ATLAS detector at the CERN Large Hadron Collider. The azimuthal correlations are probed using four-particle cumulants cn{4} and flow coefficients vn{4}=(-cn{4})1/4 for n=2 and 3, with the goal of extracting long-range multiparticle azimuthal cor

Systematic studies of correlations between different order flow harmonics in Pb-Pb collisions at s NN =2.76 TeV

The correlations between event-by-event fluctuations of anisotropic flow harmonic amplitudes have been measured in Pb-Pb collisions at sNN=2.76 TeV with the ALICE detector at the Large Hadron Collider. The results are reported in terms of multiparticle correlation observables dubbed symmetric cumulants. These observables are robust against biases originating from nonflow effects. The centrality de

Quasifree (p,pN) scattering of light neutron-rich nuclei near N=14

Background: For many years, quasifree scattering reactions in direct kinematics have been extensively used to study the structure of stable nuclei, demonstrating the potential of this approach. The RB3 collaboration has performed a pilot experiment to study quasifree scattering reactions in inverse kinematics for a stable C12 beam. The results from that experiment constitute the first quasifree sc

Influence of micromachined targets on laser accelerated proton beam profiles

High intensity laser-driven proton acceleration from micromachined targets is studied experimentally in the target-normal-sheath-acceleration regime. Conical pits are created on the front surface of flat aluminium foils of initial thickness 12.5 and 3 μm using series of low energy pulses (0.5-2.5 μJ). Proton acceleration from such micromachined targets is compared with flat foils of equivalent thi

Competition between silicifiers and non-silicifiers in the past and present ocean and its evolutionary impacts

Competition is a central part of the evolutionary process, and silicification is no exception: between biomineralized and non-biomineralized organisms, between siliceous and non-siliceous biomineralizing organisms, and between different silicifying groups. Here we discuss evolutionary competition at various scales, and how this has affected biogeochemical cycles of silicon, carbon, and other nutri

Advancing the immunoaffinity platform AFFIRM to targeted measurements of proteins in serum in the pg/ml range

There is a great need for targeted protein assays with the capacity of sensitive measurements in complex samples such as plasma or serum, not the least for clinical purposes. Proteomics keeps generating hundreds of biomarker candidates that need to be transferred towards true clinical application through targeted verification studies and towards clinically applicable analysis formats. The immunoaf

‘What are you taking away with you?’ Closing radio counselling encounters by reviewing progress

Psychological radio counselling is a relatively recent development in psychological practice, where professionals provide psychological help via mass media communication. In the media context, a professional and a help-seeker face a number of communicative challenges, one of which is to close the encounter meaningfully with regard to its counselling and radio tasks. This study explicates how radio

Quantitative and Spatially Resolved Measurement of Atomic Potassium in Combustion Using Diode Laser

compact optical setup for quantitative and spatially resolved measurement of atomic alkali concentration in combustion is demonstrated. Tunable diode laser absorption spectroscopy and laser-induced fluorescence are combined using a single continuous wave diode laser to measure the line-integration concentration and the relative distribution simultaneously, thereby obtaining the absolute concentrat

Elevated visual dependency in young adults after chemotherapy in childhood

Chemotherapy in childhood can result in long-term neurophysiological side-effects, which could extend to visual processing, specifically the degree to which a person relies on vision to determine vertical and horizontal (visual dependency). We investigated whether adults treated with chemotherapy in childhood experience elevated visual dependency compared to controls and whether any difference is

Path Generation for Affine Flow Thinning

Flow thinning (FT) is a traffic routing and protection strategy for communication networks whose links experience fluctuations in available capacity (as, e.g., in wireless networks). To cope with this phenomenon, end-to-end traffic demands are assigned dedicated tunnels (e.g., MPLS tunnels) whose nominal capacity is subject to thinning in order to account for variable capacity of the links, fluctu

A Wearable Multi-Site System for NMES-Based Hand Function Restoration

Reaching and grasping impairments significantly affect the quality of life for people who have experienced a stroke or spinal cord injury. The long-term well-being of patients varies greatly according to the restorable residual capabilities. Electrical stimulation could be a promising solution to restore motor functions in these conditions, but its use is not clinically widespread. Here, we introd

Ageing and Work in Sweden : Background Paper on Sweden, presented for the ‘Millennium Project’ conference in Tokyo, December 4th -6th, 2000, organized by the Japanese Ministry of Labour : Studies in the older workforce and the labour market

Sweden experienced a dramatic shakeout of the older workforce in the first half of the 1990s as part of the economic crisis 1991-94. The labour force participation rates and, even more pronounced the employment rates for the older workforce sank dramatically. However, when the Swedish economy recovered in the latter half of the 1990s the employment rates for the older workers, both for men and wom