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Accurate fatigue life predictions of titanium alloy components requires an understanding of how the machining affected metallurgical and micro-mechanical subsurface condition influences fatigue crack nucleation and growth. This study investigates the influence of surface integrity features generated during carbide and high-speed polycrystalline diamond machining on the fatigue behaviour of coarse

Background: Proficient Human Papillomavirus (HPV) genotyping services are essential to support HPV and cervical cancer elimination strategies, in particular to support HPV vaccine research. Objectives: To perform a global HPV genotyping proficiency study, with evaluation in relation to previous proficiency studies. Study design: The proficiency panel contained 44 coded samples (40 samples containi

Mineral dust records distant from dust sources are crucial in establishing wider atmospheric dust loads in the past. However, detailed, independent chronologies for loess-palaeosol sequences distant from local dust sources are still rare in Europe. In this study we present a high-resolution OSL and pIRIR290 chronology and multi-proxy investigation of the Irig loess-palaeosol sequence (LPS), Vojvod

Ozonation transformation products (OTPs) are largely unknown compounds that are formed during the ozonation of micropollutants, and it is uncertain to which extent these compounds can be removed by subsequent adsorption to activated carbon. Thus, 14C-labeled micropollutants were ozonated to generate 14C-labeled OTPs, for which the adsorption of the sum of all 14C-labeled OTPs to activated carbon c

Objective: The aim of this study was to assess the performance of kynurenine/tryptophan ratio for tuberculosis (TB) case-finding among antiretroviral therapy (ART)-naive people with HIV (PWH), and to investigate other factors associated with kynurenine/tryptophan ratio in this population. Design: A nested case-control study based on a cohort of 812 ambulatory PWH in the Oromia region, Ethiopia. Me

BACKGROUND: After completing university education, biomedical laboratory scientists work in clinical laboratories, in biomedical research laboratories, in biotech, and in pharmaceutical companies. Laboratory diagnostics have undergone rapid development over the recent years, with the pace showing no signs of abatement. This rapid development challenges the competence of the staff and will most cer

Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes G

Confidential computing allows processing sensitive workloads in securely isolated spaces. Following earlier adop- tion of process-based approaches to isolation, vendors are now enabling hardware and firmware support for virtualization-based confidential computing on several server platforms. Due to variations in the technology stack, threat model, implemen-tation and functionality, the available s

OBJECTIVES: Pectus excavatum (PE) can cause both physical and psychosocial symptoms and affect patients' health-related quality of life. Previous international studies have shown that the Nuss procedure increases both self-esteem and body image. The aim of the study was to evaluate the health-related quality of life in patients who have undergone the Nuss procedure for PE. METHODS: The study had a

Introduction: The rise in armed conflicts has contributed to an increase in the number of asylum seekers. Prolonged asylum processes may negatively affect asylum seekers’ health and lead to inactivity. Studies show that physical activity interventions are associated with improvements in health outcomes. However, there are a limited number of studies investigating the associations of physical activ

Insect herbivory is one of the most important ecological processes affecting plant–soil feedbacks and overall forest ecosystem health. In this study, we assess how elevated carbon dioxide (eCO2) impacts (i) leaf level insect herbivory and (ii) the stand-level herbivore-mediated transfer of carbon (C) and nitrogen (N) from the canopy to the ground in a natural mature oak temperate forest community

Innovative solutions are needed for the treatment of bacterial infections, and a range of antibacterial molecules have been explored as alternatives to antibiotics. A different approach is to investigate the immune system of the host for new ways of making the antibacterial defence more efficient. However, the immune system has a dual role as protector and cause of disease: in addition to being pr

Post-compression of ultra-short laser pulses via self-phase modulation is routinely employed for the generation of laser pulses with optical bandwidths reaching far beyond the laser gain limitations. Although high compression factors can be routinely achieved, the compressed pulses typically suffer from temporal quality degradation. We numerically and experimentally analyze the deterioration of di

The Bluethroat subspecies Cyanecula svecica svecia occurs throughout the northern Palearctic. European C. s. svecia has been shown to follow a route west of the Himalaya to winter quarters in southern Asia. Out of 30 Bluethroats tagged with geolocators in eastern Siberia, we obtained one track suggesting that it migrated east of the Himalaya to a wintering area located in Myanmar. The different ro

Objectives: This study aims to investigate if automated analyses of the trabecular pattern in intraoral radiographs independently contribute to fracture risk assessment when other risk factors incorporated in the Fracture Risk Assessment Tool (FRAX) are taken into account. A secondary aim is to explore the correlation between the automated trabecular pattern assessment in intraoral radiographs and

First measurements of balance functions (BFs) of all combinations of identified charged hadron (π,K,p) pairs in Pb–Pb collisions at sNN=2.76 TeV recorded by the ALICE detector are presented. The BF measurements are carried out as two-dimensional differential correlators versus the relative rapidity (Δy) and azimuthal angle (Δφ) of hadron pairs, and studied as a function of collision centrality. Th

Research has shown that many new parents experience taboo obsessions, which can lead to increased anxiety, depression, negative impact on parental function and quality of life. Many parents do not seek help due to shame or stigma. This cross-sectional survey study with self-recruited parents of infants and toddlers in Sweden explored: 1) the frequency and 2) impact of taboo obsessions, 3) whether

The interaction of Λ and Σ hyperons (Y) with nucleons (N) is strongly influenced by the coupled-channel dynamics. Due to the small mass difference of the NΛ and NΣ systems, the sizable coupling strength of the NΣ↔NΛ processes constitutes a crucial element in the determination of the NΛ interaction. In this letter we present the most precise measurements on the interaction of pΛ pairs, from zero re

In this paper, we identify and describe early signs of a shift towards 3rd generation UD, of which "nonclusive design" is an essential part. The paper explores the significance of such a shift using examples of the built and designed environment and of signage. Nonclusive design means design that resists categorisations of bodies/roles and that does not come with predefined or presupposed limits i