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Ideal types’ strategies related to handling early stages of the COVID-19 pandemic : A thematic analysis of comments from an international survey

People (re)act differently when facing the pandemic. Multiple opinions about COVID-19 and related issues prevail, both in personal meetings and in (social) media. This article aims to illuminate different ideal types and handling strategies in early stages of the pandemic. A thematic Braun and Clark, and Weber inspired analysis of qualitative data from an international web-based survey was carried

Child-Friendly Environments—What, How and by Whom?

The socio-physical qualities of built environments are, in several ways, of imperative importance for children growing up. The Child-Friendly Cities initiative by UNICEF, an implementation of the UN Convention on the Rights of the Child, has made local governments strive toward child-friendliness. The participation of children and young people is often the focus of such projects, with a potential The socio-physical qualities of built environments are, in several ways, of imperative importance for children growing up. The Child-Friendly Cities initiative by UNICEF, an implementation of the UN Convention on the Rights of the Child, has made local governments strive toward child-friendliness. The participation of children and young people is often the focus of such projects, with a potential

Ketamine inhibits TNF-α-induced cecal damage by enhancing RIP1 ubiquitination to attenuate lethal SIRS

Systemic inflammatory response syndrome (SIRS) is a sepsis-associated inflammatory state and a self-defense mechanism against specific and nonspecific stimuli. Ketamine influences many key processes that are altered during sepsis. However, the underlying mechanisms remain incompletely understood. In this study, TNF-α-treated mice, as well as HT-29 and L929 cell models, were applied to characterize

The Integrated Carbon Observation System in Europe

Since 1750, land-use change and fossil fuel combustion has led to a 46% increase in the atmospheric carbon dioxide (CO2) concentrations, causing global warming with substantial societal consequences. The Paris Agreement aims to limit global temperature increases to well below 2C above preindustrial levels. Increasing levels of CO2 and other greenhouse gases (GHGs), such as methane (CH4) and nitrou

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Digital technologies have undoubtedly changed the outline of the organization of the modern society and indicated an emergence of the new era of its governance. Such manifestations of digitalization as social media, platform economy, big data, AI, fintech, blockchain and internet of things have become an integral and sometimes even unnoticeable part of our life having brought up, on the one hand,

Paternal transmission of migration knowledge in a long-distance bird migrant

While advances in biologging have revealed many spectacular animal migrations, it remains poorly understood how young animals learn to migrate. Even in social species, it is unclear how migratory skills are transmitted from one generation to another and what implications this may have. Here we show that in Caspian terns Hydroprogne caspia family groups, genetic and foster male parents carry the ma

Earlier snowmelt may lead to late season declines in plant productivity and carbon sequestration in Arctic tundra ecosystems

Arctic warming is affecting snow cover and soil hydrology, with consequences for carbon sequestration in tundra ecosystems. The scarcity of observations in the Arctic has limited our understanding of the impact of covarying environmental drivers on the carbon balance of tundra ecosystems. In this study, we address some of these uncertainties through a novel record of 119 site-years of summer data

Risk assessment for endometrial cancer in women with abnormal vaginal bleeding : Results from the prospective IETA-1 cohort study

Objective: To investigate the association between personal history, anthropometric features and lifestyle characteristics and endometrial malignancy in women with abnormal vaginal bleeding. Methods: Prospective observational cohort assessed by descriptive and multivariable logistic regression analyses. Three features—age, body mass index (BMI; calculated as weight in kilograms divided by the squar

Cold sensitivity, functional disability and predicting factors after a repaired digital nerve injury

To investigate self-reported cold sensitivity and functional disability after a repaired digital nerve injury. We identified 3204 individuals operated with digital nerve repair in the Swedish national quality registry for hand surgery (HAKIR). Patient-reported symptoms, including cold sensitivity and perceived disability, were examined using two questionnaires (HQ-8 and QuickDASH), three and 12 mo

Von Willebrand factor propeptide and pathophysiological mechanisms in European and Iranian patients with type 3 von Willebrand disease enrolled in the 3WINTERS-IPS study

Background: Type 3 von Willebrand disease (VWD) is a severe bleeding disorder caused by the virtually complete absence of von Willebrand factor (VWF). Pathophysiological mechanisms of VWD like defective synthesis, secretion, and clearance of VWF have previously been evaluated using ratios of VWF propeptide (VWFpp) over VWF antigen (VWF:Ag) and factor (F)VIII coagulant activity (FVIII:C) over VWF:A

Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation

Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID-19 disease progression. Here, we characterize the efficiency of translational inhibition by clinically observed Nsp1 deletion var

Musculoskeletal pain and its association with health status, maturity, and sports performance in adolescent sport school students : a 2-year follow-up

Background: Musculoskeletal pain and its risk factors are rarely assessed in studies on adolescent athletes. The aim was to identify risk factors at baseline that were associated with the persistence or development of musculoskeletal pain at a two-year follow-up in adolescent sport school students, and to study cross-sectional associations at follow-up between musculoskeletal pain and sports perfo

Exploring Climate Change Perspectives. An Analysis of Undergraduate Students' Place-Based Attachment in Appalachia, USA

Despite global scientific consensus, climate change is a highly controversial and politicized issue in the United States. Grounded in two quantitative survey iterations with approximately 446 responses, 28 semi-structured interviews, and 4 focus groups with 60 undergraduate students from six state universities in the Appalachian region, this five-year study explores the role of place-based attachm

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with incident osteoarthritis (n = 221,807) between 1997 and 2017 and age (±2 years), gender, and practice matched controls (no osteoarthritis, n = 221,807) f