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Contractile properties of mouse single muscle fibers, a comparison with amphibian muscle fibers

Single fibers, 25-40 mu m wide and 0.5-0.7 mm long, were isolated from the flexor digitorum brevis muscle of the mouse. Force and movement were recorded (21-27 degrees C) from the fiber as a whole and, in certain experiments, from a short marked segment that was held at constant length by feedback control. The maximum tetanic force, 368 +/- 57 kN/m(2) (N = 10), was not significantly different from

Propagators and Scattering of Electromagnetic Waves in Planar Bianisotropic Slabs - An Application to Frequency Selective Structures

Scattering by planar geometries with plane metal inclusions are analysed. The metal inclusions can be of arbitrary shape,and the material of the supporting slabs can be any linear (bianisotropic) material. We employ the method of propagators to find the solution of the scattering problem. The method has certain similarities with a vector generalisation of the transmission line theory. A general rel

QT dispersion failed to estimate the global dispersion of ventricular repolarization measured using monophasic action potential mapping technique in swine and patients

The aim of this study was to evaluate whether the QT dispersion measured from 12-lead electrocardiogram (ECG) can estimate the global dispersion of ventricular repolarization (DVR) measured using a monophasic action potential (MAP) mapping technique. Monophasic action potentials were recorded from 75 +/- 12 left ventricular sites in 10 pigs and from 48 +/- 16 left or right ventricular sites in 15

Smoking and myelodysplastic syndromes

The purpose of this case-control study was to investigate tobacco smoking as a risk factor for myelodysplastic syndromes, emphasizing karyotypic aberrations as markers for exposure and risk differentiation with respect to morphology. We obtained smoking history by interview of 330 cytogenetically investigated adult myelodysplastic syndrome cases and 337 controls, matched with respect to sex, year

5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after

Close encounters in young stellar clusters: implications for planetary systems in the solar neighbourhood

The stars that populate the solar neighbourhood were formed in stellar clusters. Through N-body simulations of these clusters, we measure the rate of close encounters between stars. By monitoring the interaction histories of each star, we investigate the singleton fraction in the solar neighbourhood. A singleton is a star which formed as a single star, has never experienced any close encounters wi

Contractile effects of neuropeptide Y in human subcutaneous resistance arteries are mediated by Y1 receptors

The aim of our study was to determine the neuropeptide Y (NPY) receptor subtype responsible for the NPY-induced contraction of human subcutaneous (s.c.) resistance arteries. To elucidate this, we used (a) in vitro studies of NPY agonists: NPY, peptide YY (PYY), and Pro34NPY induced equally strong and equipotent concentration-dependent contractions of human s.c. resistance arteries, whereas NPY13-3

The epidermal growth factor-like domains of factor IX. Effect on blood clotting and endothelial cell binding of a fragment containing the epidermal growth factor-like domains linked to the gamma-carboxyglutamic acid region

The binding of factor IX to cultured bovine endothelial cells was characterized using isolated domains of bovine factor IX. An NH2-terminal fragment that consists of the gamma-carboxyglutamic acid (Gla) region linked to the two epidermal growth factor (EGF)-like domains bound to the endothelial cells with the same affinity as intact factor IX, indicating that the serine protease part of factor IX

Cryostructuration of polymer systems. XXIV. Poly(vinyl alcohol) cryogels filled with particles of a strong anion exchanger: Properties of the composite materials and potential applications

A composite material produced from a poly(vinyl alcohol) cryogel with entrapped particles of the strong anion-exchange resin Amberlite is presented. The properties of the composite material depended strongly on whether the resin was used in OH- form or Cl- form. The ion-exchange filler in OH- form caused both a significant reinforcement of the composite material and an increase in the gel fusion t

Prediction of outcome in individuals with diabetic foot ulcers: focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study

Aims/hypothesis Outcome data on individuals with diabetic foot ulcers are scarce, especially in those with peripheral arterial disease (PAD). We therefore examined the clinical characteristics that best predict poor outcome in a large population of diabetic foot ulcer patients and examined whether such predictors differ between patients with and without PAD. Methods Analyses were conducted within

Acupuncture fails to reduce but increases anaesthetic gas required to prevent movement in response to surgical incision.

Background: Acupuncture is used for clinical pain relief but has not been evaluated under clinical anaesthesia. This study was designed to compare movement in response to surgical incision in anaesthetized patients subjected to electro-acupuncture (EA) or sham procedures. Our hypothesis was that EA stimulation would reduce the requirements for anaesthetic gas. Methods: Forty-six healthy women, sc

Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

The Wilms tumor gene, WT1, encodes a zinc-finger DNA binding protein which is thought to function as a tissue specific transcription factor, regulating cell growth and differentiation. High expression of WT1 has been detected in a range of acute leukemias. To elucidate a role for WT1 in leukemogenesis, we transfected the monoblastic cell line U937, which lacks detectable levels of endogenous WT1,

Faster convergence and higher accuracy for the Dirichlet-Neumann map

New techniques allow for more efficient boundary integral algorithms to compute the Dirichlet–Neumann map for Laplace’s equation in two-dimensional exterior domains. Novelties include a new post-processor which reduces the need for discretization points with 50%, a new integral equation which reduces the error for resolved geometries with a factor equal to the system size, systematic use of regula

Epidemiology of extra-articular manifestations in rheumatoid arthritis.

Extra-articular RA (ExRA) includes a wide variety of disease manifestations. Although rheumatologists in general are aware that such events are clinically important, the heterogeneity of available data, including discrepancies in case definitions, has complicated constructive discussions on this aspect of the RA disease phenotype. In recent years, there has been a growing recognition of the import

Interfacial properties of the nanostructured dye-sensitized solid heterojunction TiO2/RuL2(NCS)(2)/CuI

The interfaces of the nanostructured dye-sensitized solid heterojunction TiO2/Ru-dye/CuI have been studied using photoelectron spectroscopy of core and valence levels, x-ray absorption spectroscopy and atomic force microscopy. A nanostructured anatase TiO2 film sensitized with RuL2(NCS)(2) [cis-bis(4,4'-dicarboxy-2,2'-bipyridine)-bis(isothio-cyanato)-ruthenium(II)] was prepared in a controlled way

Structurable algebras and models of compact simple Kantor triple systems defined on tensor products of composition algebras

Let $(A,^−)$ be a structurable algebra. Then the opposite algebra $(A^{op},^−)$ is structurable, and we show that the triple system $B_A^{op}(x,y,z):=V_{x,y}^{op}(z)=x(\overline y z)+z(\overline y x)−y(\overline x z),x,y,z\in A$, is a Kantor triple system (or generalized Jordan triple system of the second order) satisfying the condition $(A)$. Furthermore, if $A=\mathbb{A}_1\otimes\mathbb{A}_2$ de

Comparison of analysis of the different prostate-specific antigen forms in serum for detection of clinically localized prostate cancer

OBJECTIVES: To compare different forms and ratios of serum prostate-specific antigen (PSA) to determine which form or ratio provides optimal diagnostic specificity and sensitivity in distinguishing between benign prostatic hyperplasia (BPH) and clinically localized prostate cancer. METHODS: Serum samples were obtained from 47 patients with BPH and 39 with clinically localized prostate cancer. Pati