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Do Regions Make a Difference? Regional Innovation Systems and Global Innovation Networks in the ICT Industry

Access to global innovation networks (GINs) has been unequal across the regions of the world. While certain regions are considered knowledge hubs in GINs, others still remain marginalized; this points to the role of regional innovation systems (RISs) in the emergence and development of GINs. Using firm-level data collected through a survey and case studies in 2009-2010, this paper systematically c

Protein crystallography from the perspective of technology developments

Early on, crystallography was a domain of mineralogy and mathematics and dealt mostly with symmetry properties and imaginary crystal lattices. This changed when Wilhelm Conrad Rontgen discovered X-rays in 1895, and in 1912, Max von Laue and his associates discovered that X-ray irradiated salt crystals would produce diffraction patterns that could reveal the internal atomic periodicity of the cryst

X-ray diffraction from the ripple structures created by femtosecond laser pulses

In this paper, we present the investigation and characterization of the laser-induced surface structure on an asymmetrically cut InSb crystal. We describe diffraction from the ripple surface and present a theoretical model that can be used to simulate X-ray energy scans. The asymmetrically cut InSb sample was irradiated with short-pulse radiation centred at 800 nm, with fluences ranging from 10 to

Hyperbaric oxygen therapy as treatment of diabetic foot ulcers

Hyperbaric oxygen therapy (HBO) could be described as a short-term, high-dose oxygen inhalation and diffusion therapy, delivered systemically through airways and blood, achieved by having the patient breathing concentrated oxygen at a pressure higher than 1 absolute atmosphere. In clinical practice, monoplace or multiplace hyperbaric chambers are used to achieve this. Treatment is usually given as

Indirect Estimation of Semiparametric Binary Choice Models

One of the most cited studies within the field of binary choice models is that of Klein and Spady (1993), in which the authors propose a semiparametric estimator for use when the distribution of the error term is unknown. However, although theoretically appealing, the estimator has been found to be difficult to implement, and therefore not very attractive from an applied point of view. The current

New evidence on the introduction, cultivation and processing of hemp (Cannabis sativa L.) in southern Sweden

Subfossil remains of Cannabis sativa L. (hemp) have been found at Lindangelund in the region of Malmo, southern Sweden. These represent the earliest robust evidence so far for hemp retting in Scandinavia. Finds of seeds, stems and pollen of C. sativa from a waterlogged context on a settlement dating to the Roman Iron Age demonstrate that the plant was locally cultivated and processed during the 1s

Search for third generation scalar leptoquarks in pp collisions at root s=7 TeV with the ATLAS detector

A search for pair-produced third generation scalar leptoquarks is presented, using proton-proton collisions at root s = 7 TeV at the LHC. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 4.7 fb(-1). Each leptoquark is assumed to decay to a tau lepton and a b-quark with a branching fraction equal to 100%. No statistically significant excess above the Stan

School Achievement and Risk of Eating Disorders in a Swedish National Cohort.

High achievement in school has been associated with increased risk of eating disorders, including anorexia nervosa (AN) and bulimia nervosa (BN), but causality of these relationships is unclear. We sought to examine the association between school achievement and AN or BN in a national cohort and to determine the possible contribution of familial confounding using a co-relative design.

Dependence of Resonance Energy Transfer on Exciton Dimensionality

We investigate the dependence of resonance energy transfer from Wannier-Mott excitons to an organic overlayer on exciton dimensionality. We exploit the excitonic potential disorder in a single quantum well to tune the balance between localized and free excitons by scaling the Boltzmann distribution of excitons through temperature. Theoretical calculations predict the experimentally observed temper

Effects of a dual CCR3 and H-1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitis

Background: The CC-chemokine receptor-3 (CCR3) has emerged as a target molecule for pharmacological intervention in allergic inflammation. Objective: To examine whether a dual CCR3 and H-1-receptor antagonist (AZD3778) affects allergic inflammation and symptoms in allergic rhinitis. Methods: Patients with seasonal allergic rhinitis were subjected to three seven days' allergen challenge series. Tre

Long-term follow-up of lung and heart transplant recipients with pre-transplant malignancies

BACKGROUND: Concern regarding recurrence of pre-transplant (Tx) malignancy has disqualified patients from Tx. Because this has been poorly studied in lung and heart Tx recipients our aim was to investigate the influence of pre-Tx malignancy on post-Tx recurrence and long-term survival, focusing on pre-operative cancer-free intervals. METHODS: From our lung and heart Tx programs (1983 to 2011) we r

Dimension splitting for quasilinear parabolic equations

In the current paper, we derive a rigorous convergence analysis for a broad range of splitting schemes applied to abstract nonlinear evolution equations, including the Lie and Peaceman-Rachford splittings. The analysis is in particular applicable to (possibly degenerate) quasilinear parabolic problems and their dimension splittings. The abstract framework is based on the theory of maximal dissipat

Haptoglobin: the hemoglobin detoxifier in plasma

Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have only recently become active areas of research. New insights into the protective mechanisms of haptoglobin (Hp), a plasma protein, and a timely resolution of the crystal structure of the Hb-Hp complex made

Gaia: Astrometric performance and current status of the project

The scientific objectives of the Cain mission cover areas of galactic structure and evolution, stellar astrophysics, exoplanets, solar system physics, and fundamental physics. Astrometrically, its main contribution will be the determination of millions of absolute stellar parallaxes and the establishment of a very accurate, dense and faint non-rotating optical reference frame. With a planned launc

Regional biomass planning – Helping to realise national renewable energy goals?

Biomass will make a vital contribution to the EU renewable energy targets, however large amounts need to be mobilised to achieve policy goals. To promote action, the European Commission sent a firm call to member states for coordinated biomass strategies and plans, and engagement of sub-national actors. This paper examines how regional level biomass planning can benefit national planning and EU ta

Presymptomatic autoantibodies in Sjögren's syndrome: what significance do they hold for the clinic?

In a number of autoimmune diseases, for example, rheumatoid arthritis and systemic lupus erythematosus, it is known that autoantibodies are present before the clinical onset. Recently we have shown that autoantibodies can be found many years before symptom onset in primary Sjögren's syndrome. This implies that screening for autoantibodies may be used to identify individuals at risk of developing s

Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has