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Impact of pregestational weight and weight gain during pregnancy on long-term risk for diseases

Objective: The aim of this study was to analyse the impact of maternal BMI at start of pregnancy and maternal weight gain during pregnancy on the risk of various diseases later in life. Methods: In a population-based cohort from southern Sweden, women with at least one delivery registered in the Swedish Medical Birth Register ten or more years before answering a health questionnaire were identifie

The Olson method for detection of acute myocardial ischemia in patients with coronary occlusion

An automated ECG-based method may provide diagnostic support in the management of patients with acute coronary syndrome. The Olson method has previously proved to accurately identify the culprit artery in patients with acute coronary occlusion. Methods The Olson method was applied to 360 patients without acute myocardial ischemia and 52 patients with acute coronary occlusion. Results This study es

Alkalosis in critically ill patients with severe sepsis and septic shock

Introduction: Although metabolic alkalosis is a common occurrence in intensive care units (ICUs), no study has evaluated its prevalence or outcomes in patients with severe sepsis or septic shock. Methods: This is a retrospective cohort study of critically ill patients suffering from severe sepsis and septic shock admitted to the ICUs of Halmstad and Varberg County hospitals. From 910 patient recor

STAT3 in Prostate Cancer

Prostate cancer is the second most common diagnosed cancer among men. Currently there are no reliablebiomarkers to distinguish between indolent and aggressive disease. When men progress to advanced stages of the disease treatment options are limited and resistance to treatments available today is a growing problem. Recently the signal transducer and activator of transcription 3 (STAT3) has been su

What factors are important to patients when assessing treatment response : An international cross-sectional survey

This study investigated the perspective of international patients on individual symptoms of atopic dermatitis (eczema) in determining treatment response. A questionnaire was developed to evaluate the importance of symptoms from the patient’s perspective. Patients were asked: “How important are these features in deciding whether or not a treatment is working?”, and rated symptoms on a 5-point Liker

Resilience and Risk for Alcohol Use Disorders : A Swedish Twin Study

Background: Resilience has been shown to be protective against alcohol use disorders (AUDs), but the magnitude and nature of the relationship between these 2 phenotypes are not clear. The aim of this study was to examine the strength of this relationship and the degree to which it results from common genetic or common environmental influences. Methods: Resilience was assessed on a 9-point scale du

Hepatic DPP4 DNA methylation associates with fatty liver

Hepatic DPP4 expression is elevated in subjects with ectopic fat accumulation in the liver. However, whether increased dipeptidyl peptidase 4 (DPP4) is involved in the pathogenesis or is rather a consequence ofmetabolic disease is not known. We therefore studied the transcriptional regulation of hepatic Dpp4 in young mice prone to diet-induced obesity. Already at 6 weeks of age, expression of hepa

Writing, stitching, inking : Different modes of creating historical narratives

This article presents an analysis of different ways of producing historical narratives in the Swedish football environment. The examples are based on the activities around AIK, a top league football club from Stockholm. In the article I present a tifo and a tattoo, stitching and inking, as actual modes of writing history. Big clubs like AIK not only attract many fans, but also stimulate creative e

Applications of Signal Processing to Microphone Node Calibration and Medical Signal Classification

Localization is an important enabling technology for many applications, such as wireless sensor networks, emergency rescue services, civil defense and transportation. Suppose that a room is equipped with several microphones (or sensors), and one person is making a sound while moving around in the room. Can one find microphone and sound source positions as well as reconstruct a room geometry? The a

Delayed cochlear implantation in post-meningitic deafness and hereditary complement C2 deficiency

We report the case of an adolescent with post-verbal severe/profound sensorineural hearing loss, occurring as a consequence of two bouts of pneumococcal meningitis at 12 and 32 months of age. A possible immunodeficiency was investigated, revealing hereditary complement C2 deficiency (C2D). Given the insufficient benefit from high-power hearing aids, the boy received a cochlear implant (CI) at age

Galen Wagner, M.D., Ph.D. (1939–2016) as international mentor of young investigators in electrocardiology

This paper describes a substantial part of the international mentoring network of students and young investigators in electrocardiology that developed around Dr. Galen Wagner (1939–2016), including many experiences of his mentees and co-mentors. The paper is meant to stimulate thinking about international mentoring as a means to achieve important learning experiences and personal development of yo