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The human antibody repertoire to infectious agents: implications for disease pathogenesis

Antibodies are critical entities used for the protection of an individual organism against infection and disease. Through a complex series of events genes rearrange to encode repertoires of molecules, which are tested for their ability to identify foreign molecules. In this report, we discuss factors defined by the individual as well as by infectious organisms that shape the antibody repertoire. A

Judisk tro och kristen i ett religionsteologiskt perspektiv

The article examines some of the tradition answers to the questions what differs Judaism from Christianity, comparing those from antiquity to answers articulated during the 19th and 20th centuries. It is argued that representatives of Christianity constantly need to examine traditional answers. The encounter with living Judaism is essential, with the words of Leo Baeck: "Man muss die Juden kennen,

Preliminary evaluation of two fluorescence imaging methods for the detection and the delineation of basal cell carcinomas of the skin

Abstract Background and ObjectiveFluorescence techniques can provide powerful noninvasive means for medical diagnosis, based on the detection of either endogenous or exogenous fluorophores. The fluorescence of δ-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has already shown promise for the diagnosis of tumors. The aim of the study was to investigate the localization of skin tumors a

Extended operation with or without intraoperative (IORT) and external (EBRT) radiotherapy for gallbladder carcinoma.

BACKGROUND/AIMS: Gallbladder carcinoma is a rare disease with dismal prognosis. However, lately improved survival has been reported after extended operation including liver resection and lymphadenectomy in addition to cholecystectomy. The aim of this study was to evaluate such a surgical strategy with and without adjuvant intra- and postoperative radiotherapy (IORT/EBRT). METHODOLOGY: 20 patients

MORAXELLA CATARRHALIS OUTER MEMBRANE PROTEINS AND INTERACTIONS WITH THE HUMAN IMMUNE SYSTEM

Popular Abstract in Swedish Moraxella catarrhalis är en bakterie som man länge trodde var en del av vår normala bakterieflora och därmed ofarlig. Under de senaste tjugo åren har M. catarrhalis dock visat sig vara en av orsakerna till öroninflammation hos barn och lägre luftvägsinfektioner hos vuxna med någon annan underliggande sjukdom som t.ex. kronisk obstruktiv lungsjukdom (KOL). De senaste 10 Moraxella catarrhalis is frequently colonizing the human respiratory tract, particularly in children. This gram-negative bacterium has during the last two decades been recognized as a pathogen causing otitis media in children and lower respiratory tract infections in adults with predisposing conditions such as chronic obstructive pulmonary disease (COPD). The virulence determinants of M. catarrhal

För få kranskärlspatienter får lipidsänkande behandling [Few patients with coronary diseases are receiving lipid-lowering therapy]

I Sverige finns sedan flera år riktlinjer för hur förhöjda blodfetter bör behandlas hos patienter med kranskärlssjukdom. Generellt är intresset för och kunskapen om lipidbehandling stort inom den svenska läkarkåren. Trots detta nås uppsatta mål för behandling av blodfetter hos endast en minoritet av patienterna, och hälften av dem får inte någon farmakologisk lipidsänkande behandling, enligt en ny

The impact of six European tree species on the chemistry of mineral topsoil in forest plantations on former agricultural land

Influences on mineral topsoils of common European tree species (oak-Quercus robur L., lime-Tilia cordata Mill., ash-Fraxinus excelsior L., birch-Betula pendula Roth., beech-Fagus sylvatica L. and spruce-Picea abies (L.) Karst.) were studied in 30 to 40-year-old stands planted in adjacent plots on former arable land. Mineral soil samples from two depth layers (0-10 and 20-30 cm) under the different

Evidence for isovector neutron-proton pairing from high-spin states in N=Z Rb-74

High-spin states in the odd-odd N=Z nucleus Rb-74(37)37 were studied using the Ca-40(Ca-40,alphanp) reaction. A previously observed odd-spin T=0 band has been extended to I-pi=(31(+)) and an even-spin T=0 band has been observed for the first time to I-pi=(22(+)); both have a pi(g(9/2))circle timesnu(g(9/2)) structure. A strongly coupled low-spin T=0,K=3 band has been interpreted as being based upo

Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase

The human platelet cilostamide- and cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) was rapidly purified approximately 19,000-fold to apparent homogeneity using single step affinity chromatography on the isothiocyanate derivative of cilostamide coupled to aminoethyl agarose. Within 24 h, 30 micrograms of enzyme protein was obtained from 20 ml of packed platelets. Vmax for cAMP and cGMP was 6.1 and

Laser spectroscopy of gas in scattering media at scales ranging from kilometers to millimeters

Free gases are characterized by their narrow line width, and they can conveniently be studied by laser spectroscopy. The present paper discusses the monitoring of such ambient pressure gases, which are dispersed in scattering media such as aerosol-laden atmospheres, solids, or liquids. Atmospheric work basically constitutes the well-known field of differential absorption lidar (DIAL), while the st

Correlated electron tunneling in the single-molecule nanosystems

The original approach to the creation of high-temperature single-electron tunneling systems has been developed based on the use of nanocluster molecules. The morphology and electron tunneling characteristics through single nanocluster molecules organized as highly-ordered monolayer Langmuir-Blodgett films on atomically-flat graphite substrate have been studied experimentally using scanning tunneli

A Probing Control Strategy: Stability and Performance

An extremum controller based on a pulse technique is examined. Plants consisting of the cascade of a piecewise linear static function and a LTI system are considered. Numerical methods for stability and performance analysis of the closed-loop systems are derived. Performance is measured by the ability to track a time-varying optimal point. An illustrative example where it is desirable to control t

Insulin detemir har jämförts med NPH-insulin. Behandlingsstudier visar inga egentliga skillnader

To investigate the evidence behind supposed advantages of insulin detemir over existing therapy (NPH insulin), we carried out a systematic review. We analysed the available documentation presented after registration of the drug by the European drug regulatory authority (EMEA) and approached the data presented at the authority's Internet site. Some data from Food and Drug Administraion (FDA) contri

Structural and Thermodynamic Studies on Cation- Interactions in Lectin-Ligand Complexes: High-Affinity Galectin-3 Inhibitors through Fine-Tuning of an Arginine-Arene Interaction

The high-resolution X-ray crystal structures of the carbohydrate recognition domain of human galectin-3 were solved in complex with N-acetyllactosamine (LacNAc) and the high-affinity inhibitor, methyl 2-acetamido-2-deoxy-4-O-(3-deoxy-3-[4-methoxy-2,3,5,6-tetrafluorobenzamido]--D-galactopyranose)--D-glucopyranoside, to gain insight into the basis for the affinity-enhancing effect of the 4-methoxy-2

Fracture mechanics studies of non-yielding materials like concrete : modelling of tensile fracture and applied strength analyses

Fracture mechanics studies of non-yielding materials are presented. The studies are based on theoretical models for the macroscopical mechanical behaviour of materials during tensile stress induced fracture. A number of applied numercal analysis are indicated. Fracture models and strength relations are discussed also from a few more general and fundamental points of view. A number of comparisons a

Kvalet inför valet: Om elevers förväntningar och möten med vägledare i grundskolan

Popular Abstract in Swedish Med utgångspunkt i elevers väljande till gymnasieskolan har denna studie fokuserat på hur eleverna upplever detta val och med särskild betoning på samtalen mellan skolans syokon-sulenter (studie- och yrkesvägledare) och elever. Åtta elever har valts ut och samtliga deras samtal i årskurs nio med vägledare (4 stycken) har videoinspelats och analyserats. Dessutom har elevThe main purpose of this study is to highlight the counselling interview in connection with the choice of upper secondary school from three perspectives, the student's, the counsellor's and society's. The intention is to describe and analyse the counselling interview in the ninth grade with relation to: · the student's expectations, perceptions and values before and after the interviews, · the co

Vertebral deformation in urban Swedish men and women: prevalence based on 797 subjects

Vertebral fracture-deformation, a common feature of osteoporosis, shows considerable age, sex and geographical variation. We present the prevalence in an urban population of south-west Sweden. Lateral spine radiographs of 797 men and women, age 50-86 years, were evaluated by morphomety. The age-standardized prevalence of subjects with vertebral deformation using the deformation criterion -3 SD was