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Entrepreneurship and the Creation of Organization

When re-imagining, re-thinking, and re-writing entrepreneurship in this book, the authors have come to the conclusion that the concept that describes it most precisely is one that signifies a process that includes imagining, seductively describing, playfully organizing, political agility in navigating common sense, and business sensibility before possible commerce.This book develops a process theo

Automated tight Lyapunov analysis for first-order methods

We present a methodology for establishing the existence of quadratic Lyapunov inequalities for a wide range of first-order methods used to solve convex optimization problems. In particular, we consider (i) classes of optimization problems of finite-sum form with (possibly strongly) convex and possibly smooth functional components, (ii) first-order methods that can be written as a linear system on

Highly Accurate Blood Test for Alzheimer's Disease Comparable or Superior to Clinical CSF Tests

With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting amyloid-β (Aβ) plaques and tau tangles. Plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was an

Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults

Dicarbonyl compounds are highly reactive precursors of Advanced Glycation End-products (AGEs), produced endogenously, present in certain foods, and formed during food processing. AGEs contribute to development of adverse metabolic outcomes but health effects of dietary dicarbonyls are largely unexplored. We investigated associations between three dietary dicarbonyl compounds, methylglyoxal (MGO),

Beta-lactam antibiotic concentrations in critically ill patients with standard and adjusted dosages: A prospective observational study

IntroductionAntibiotic concentration target attainment is known to be poor in critically ill patients. Dose adjustment is recommended in patients with altered clearance, obesity and those with bacterial species with intermediate susceptibility. The aim of this study was to investigate the variation of antibiotic concentration in critically ill patients with standard or adjusted dosing regimens.Met

Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection - A substudy of the DIANA study

PurposeIn a retrospective cohort study of intensive care unit (ICU) admitted adult patients with suspected or confirmed infection, associations between combination versus mono empirical antibiotic therapy and clinical cure at day 7 as well as mortality at day 7 and 28, were investigated.Materials and methodsPatients from the DIANA study were grouped and analysed by combination versus mono antibiot

A resilience approach to DMO communication during the COVID-19 pandemic.

This article addresses how urban Destination Management Organisations (DMOs) in Sweden, have understood their communicative role, developed communicative strategies and tactics in relation to stakeholders during the COVID-19 pandemic. The aim of this research is to explore communication strategies for urban destination resilience. DMOs have a key role in balancing the interest of stakeholders, the

Deep learning performance on MRI prostate gland segmentation : evaluation of two commercially available algorithms compared with an expert radiologist

PURPOSE: Accurate whole-gland prostate segmentation is crucial for successful ultrasound-MRI fusion biopsy, focal cancer treatment, and radiation therapy techniques. Commercially available artificial intelligence (AI) models, using deep learning algorithms (DLAs) for prostate gland segmentation, are rapidly increasing in numbers. Typically, their performance in a true clinical context is scarcely

Small-Molecule Galectin Ligands : Structure-Based Optimisation of Affinity and Selectivity

In the body, all cell surfaces are covered with glycans, and many regulatory components havecarbohydrates attached to them, which can aid in their function. Galectins are a family of proteins whichcan bind to specific glycans and oligosaccharides and cross-link them to influence a wide range of cellularprocesses. The members of the galectin family are structurally similar and can be involved in th

Distributed MIMO Measurements for Integrated Communication and Sensing in an Industrial Environment

Many concepts for future generations of wireless communication systems use coherent processing of signals from many distributed antennas. The aim is to improve communication reliability, capacity, and energy efficiency and provide possibilities for new applications through integrated communication and sensing. The large bandwidths available in the higher bands have inspired much work regarding sen

Real-time Bayesian control of reactive brain computer interfaces

This paper introduces an improved method for real-time brain computer interface control. We demonstrate how Bayesian optimization and feedback can be used to achieve faster statistical convergence by controlling the sequence of stimuli shown in a brain computer interface based on a visual oddball paradigm.

Thermoregulatory consequences of growing up during a heatwave or a cold snap in Japanese quail

Changes in environmental temperature during development can affect growth, metabolism and temperature tolerance of the offspring. We know little about whether such changes remain to adulthood, which is important to understand the links between climate change, development and fitness. We investigated whether phenotypic consequences of the thermal environment in early life remained in adulthood in t

Inoculation with adapted bacterial communities promotes development of full scale slow sand filters for drinking water production

Gravity-driven filtration through slow sand filters (SSFs) is one of the oldest methods for producing drinking water. As water passes through a sand bed, undesired microorganisms and chemicals are removed by interactions with SSF biofilm and its resident microbes. Despite their importance, the processes through which these microbial communities form are largely unknown, as are the factors affectin