Class Ib ribonucleotide reductases (RNR) utilize a di-nuclear manganese or iron cofactor for reduction of superoxide or molecular oxygen, respectively. This generates a stable tyrosyl radical (Y·) in the R2 subunit (NrdF), which is further used for ribonucleotide reduction in the R1 subunit of RNR. Here, we report high-resolution crystal structures of Bacillus anthracis NrdF in the metal-free form

För hundra år sedan började den katolska tidskriften Credo, föregångaren till dagens Signum, utkomma. Den var på många sätt typisk för sin tid och för de strömningar som då gjorde sig gällande i den katolska världen. I denna artikel analyseras Credo under pionjärtiden de första tolv åren och sätts in i sitt samtida katolska sammanhang.

This randomized trial compared the effects of imagery rescripting against in vivo exposure administered separately during a single session with 27 socially anxious individuals. Previous research shows that imagery rescripting is a promising treatment technique for various disorders including social anxiety, although imagery rescripting and exposure for social anxiety have not yet been compared. So

OBJECTIVE: To characterize the systemic phenotype of primary Sjögren's syndrome at diagnosis by analysing the EULAR-SS disease activity index (ESSDAI) scores.METHODS: The Sjögren Big Data Consortium is an international, multicentre registry based on worldwide data-sharing cooperative merging of pre-existing databases from leading centres in clinical research in Sjögren's syndrome from the five con

Four hundred eighty-three specimens of the genus Parmelia collected in Belarus were examined. Four species, P. ernstiae, P. saxatilis, P. serrana and P. sulcata, were identified in this study. The distribution of these species in Belarus is reviewed. Parmelia saxatilis appeared to be an extremely rare species in Belarus known from a single locality. Parmelia ernstiae is reported from Belarus for t

Background: Nucleic acid hybridization (NAH) of hepatitis C virus (HCV) is a practical and reliable tool for virus genotyping. Genotype assignment is an important factor in the prediction of treatment success in chronic hepatitis C patients. The aim of this study was to determine the genotype distribution among HCV clinical isolates in Jordan between 2007 and 2018. Methods: Electronic and paper-ba

A simplified combined-slip model that only considers the extreme case at the friction limit is suggested and used in a closed-loop controller for autonomous vehicle handling in at-the-limit maneuvers. In the development of the controller it is assumed that the front wheels are individually steered, but it is demonstrated in a left-hand turn scenario that with a simple adaptation, the method is sti

Trots att PBL betraktas som ett kraftfullt verktyg i undervisningen, råder fortfarande viss tvekan att den skulle vara lämplig i alla utbildningar. Ett annat problem som också diskuteras är om PBL går att tillämpas på stora grupper och i så fall om den är lönsam. I tekniska utbildningar är teknologerna oftast vana vid att ha föreläsningar, övningar och laborationer. Som stöd har man ett genomarbet

There are large discrepancies in the transport sector along gender lines in travel patterns and means of transportation used, but also in attitudes and norms among citizens, planners and decision-makers, with women generally more positive towards measures involving the lowering CO2 emissions. At the same time, the number of women involved in transport-related decisions is low. This is a problem fo

DEBATT. I ljuset av den försämrade konjunkturen höjs allt fler röster för en generösare finanspolitik. Men Sveriges ekonomiska utmaningar går djupare och budskapet från bland annat Japan och USA är tydligt: stora budgetunderskott höjer inte tillväxten på sikt, skriver Fredrik NG Andersson och Lars Jonung vid Lunds universitet.

The development of tools to help cities and water utility authorities communicate and plan for long-term sustainable solutions is of utmost importance in the era of a changing and uncertain climate. This study introduces a hybrid modeling concept for the cosimulation of mesoscale blue-green stormwater systems and conventional urban sewer networks. The hybrid model successfully introduces the reten

PURPOSE: Large upper eyelid defects can be repaired by rotational full-thickness lower eyelid flaps. The aim was to measure the blood perfusion in such flaps, and how it is affected by the length of the flaps, and the degree of rotation and stretching.METHODS: Nine patients underwent the Quickert procedure for entropion repair in which a full-thickness eyelid flap of approximate width 0.5 cm and l

The use of Alcohol-based antiseptics is efficient and approved, however it has some limitations. This paper examined the possibility of using hypochlorite water as a chlorine-based antiseptic for handwashing in public buildings and healthcare facilities. The electrolysis method was used, which produces Hypochlorous acid (HOCl) from mixing drinking water with small amounts of sodium hydroxide. Hypo

Cities have for a long time been key actors in sustainable urban development, and in recent times, also for the sharing economy, as they provide a fertile breeding ground for various sharing initiatives. While some of these initiatives build on existing practices and infrastructures such as public libraries and repair workshops, others require the involvement of private companies, as in the case o