BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare clinical syndrome characterized by intraperitoneal accumulation of mucus produced by neoplastic cells of mostly appendiceal origin. The aim of this study was to analyze primary and secondary involvement and treatment-related complications of the urinary tract in PMP.METHODS: A retrospective study of 92 patients with PMP, treated by cytoreduction a

AIMS: To report on treatment related toxicity and mortality in patients with pseudomyxoma peritonei (PMP) treated by cytoreduction in combination with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and to identify prognostic factors.METHODS: A review was performed of 103 procedures of cytoreduction and intraoperative HIPEC for PMP between 1996 and 2004. Toxicity was graded accord

AIMS: To report the results of standard therapy for peritoneal carcinomatosis of colorectal origin, which consists of conventional surgery and systemic chemotherapy.METHOD: In a prospective study 50 patients with proven peritoneal carcinomatosis of colorectal origin were treated with conventional surgery combined with 5-fluorouracil and leucovorin, or irinotecan in patients treated by 5-fluorourac

BACKGROUND: Peritoneal carcinomatosis of colorectal cancer is probably best treated by cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC). In The Netherlands Cancer Institute, this treatment has been performed since 1995. The long tradition of this treatment enabled us to study long-term survival in detail.METHODS: Between 1995 and 2003, 117 patients were treated by cytoreduction

Multiplex Antibody-Detection by Agglutination-PCR (ADAP) assay was compared to singleplex standard radiobinding assays (RBA) to detect autoantibodies against insulin (IAA), GAD65 (GADA), islet antigen-2 (IA-2A), ZnT8 (ZnT8A) and tissue transglutaminase (TGA). Serum samples from 272 (114F/158M), 15-73 years of age healthy controls and 227 (109F/118M) newly diagnosed type 1 diabetes children, 1-11 y

OBJECTIVE: Lower limb lymphedema (LLL) is a chronic condition. To be able to evaluate changes of LLL over time and effects of interventions reliable measurement methods are important. Currently, there is limited knowledge of the reliability of commonly used measurement methods in LLL. The study objective was to evaluate the test-retest (intrarater) reliability of impedance of extracellular fluid,

PurposeLonger and heavier road freight vehicles, so called High Capacity Vehicles (HCVs) are likely to be implemented by the Swedish government in the near future. This paper analyses the effects on tonne-kilometres, vehicle-kilometres, CO2 and socio-economics of three possible implementation strategies (HCVs on all roads, a designated road network, a designated road network with km-based truck ch

The most common indications for magnetic resonance imaging (MRI) of the brachial plexus (BP) are traumatic injuries. The role of MRI of the BP has increased because of recent trends favoring earlier surgery. Determining preganglionic vs. postganglionic injury is essential, as different treatment strategies are required. Thus, MRI of the BP should be supplemented with cervical spine MRI to assess t

Purpose: This paper explores the quality and flow of facade product information and the capabilities for avoiding the risk of facade fires early in the design process. Design/methodology/approach: A qualitative case study using the process tracing method is conducted in two stages. First, a thematic analysis of reports and literature identified two categories for the problems that caused fast fire

Various studies have claimed that the sense of agency is based on a comparison between an internal estimate of an action’s outcome and sensory feedback. With respect to speech, this presumes that speakers have a stable prearticulatory representation of their own speech. However, recent research suggests that the sense of agency is flexible and thus in some contexts we may feel like we produced spe

Environmental disasters, and especially floods, are among today's biggest sustainability challenges. The number and intensity of floods are increasing, challenging current governance approaches. Governments worldwide are looking to diversify their flood risk management and adaptation strategies, among others, by increasing resident involvement in flood risk governance. Such involvement of individu

Diffusion encoding with free gradient waveforms can provide increased microstructural specificity in heterogeneous tissues compared to conventional encoding approaches. This is achieved by considering specific aspects of encoding, such as b-tensor shape, sensitivity to bulk motion and to time-dependent diffusion (TDD). In tensor-valued encoding, different b-tensor shapes are used, such as in linea

Background: The Glanville fritillary (Melitaea cinxia) butterfly is a model system for metapopulation dynamics research in fragmented landscapes. Here, we provide a chromosome-level assembly of the butterfly's genome produced from Pacific Biosciences sequencing of a pool of males, combined with a linkage map from population crosses. Results: The final assembly size of 484 Mb is an increase of 94 M

Existing studies offer little insight on how atrial fibrillation (AF) detection performance is influenced by the properties of AF episode patterns. The aim of this study is to investigate the influence of AF burden and median AF episode length on detection performance. For this purpose, three types of AF detectors, using either information on rhythm, rhythm and morphology, or ECG segments, were in