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There is a need for novel strategies to initiate cancer cell death. One approach is the use of Smac mimetics, which antagonize inhibitor of apoptosis proteins (IAPs). Recent studies have shown that combinations of Smac mimetics such as LBW242 or LCL161 in combination with chemotherapeutic agents increase cancer cell death. Here we show that the protein kinase C (PKC) activator TPA together with th
Definitions and understandings of disease are to a large extent culturally dependent, even if there are also biological components to this. While many medieval religious orders nursed an interest for science and knowledge in general, their approach to medicine was complicated by the complex attitude towards illness and the tending of the body within Christendom. Archaeological artifacts from Ciste
Is the Rojava model really deconstructing the model of a state or is it potentially a new state form? Does the ‘democratic confederalism’ model that the Kurdish movement claims to be implementing in Northern Syria draw on/reproduce different modes of identity/belonging than that of the nation and the state? This paper argues that the shift from a nationalist movement towards a project that offers
Despite the enormous amount of attention CH 3 NH 3 PbI 3 has received, we are still lacking an in-depth understanding of its basic properties. In particular, the directional mechanical and structural characteristics of this material have remained elusive. Here, we investigate these properties by monitoring the propagation of longitudinal and shear phonons following the absorption of a femtosecond
Scarcity of in situ measurements of greenhouse gas (GHG) fluxes hamper calibration and validation of continental assessments of carbon budgets in Africa. It limits essential studies of ecosystem functioning and ecosystem processes. Wide reported ranges of estimated African net primary production (NPP) and gross primary production (GPP) is a function of the uncertainty originating from this scarcit
Denne teksten presenterer en side av Marx' filosofi som ikke har fått like mye oppmerksomhet som hans kapitalismekritikk, nemlig hans kritikk av menneskerettighetene. FNs menneskerettighetserklæring regnes i dag som det viktigste dokumentet for internasjonalt samarbeid. Til sammenligning er Marx' syn at menneskerettighetene skaper egoisme og svekker kollektivets samhold. Teksten presenterer dette
Background: Media frequently report on overall work-place challenges in Swedish schools, including teachers’ working conditions, their well-being, and students’ declining results. Language is the key to success in every school subject. Therefore, optimal language learning environments are important. Poor sound environments affect teachers’ vocal health, their general well-being, and students’ perf
OBJECTIVE: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected infections. This study aimed to evaluate the plasma-levels of HBP as a prognostic biomarker for infection-induced organ dysfunction among patients seeking medic
Edward Joseph Snowden blev världsberömd när han visselblåste om USA:s statliga övervakningsprogram. Amnesty International kallade honom en hjälte som främjade mänskliga rättigheter och tvingade fram en viktig global debatt om massövervakning. Som en kontrast till detta skrev den faste skribenten i The New Yorker, Jeffrey Toobin, att Snowden är ”en grandios narcissist som förtjänar att sitta i fäng
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome has been extensively analyzed in the context of inflammation and infectious diseases. Here, we show that the proteasomal immunosubunit LMP7 plays an es
Insulin stimulates Na+,K+-ATPase activity and induces translocation of Na+,K+-ATPase molecules to the plasma membrane in skeletal muscle. We determined the molecular mechanism by which insulin regulates Na+,K+-ATPase in differentiated primary human skeletal muscle cells (HSMCs). Insulin action on Na +,K+-ATPase was dependent on ERK1/2 in HSMCs. Sequence analysis of Na+,K+-ATPase α-subunits reveale
Artikel om Claus Schenk Graf von Stauffenberg och attentatet mot Adolf Hitler 1944 samt synen på Stauffenberg efter att han avrättats.
