Introduction: The impact of exposure to endemic infections on basal immunity and susceptibility to HIV-1 acquisition remains uncertain. We hypothesized that exposure to infections such as cytomegalovirus (CMV), malaria and sexually transmitted infections (STIs) in high-risk individuals may modulate immunity and subsequently increase susceptibility to HIV-1 acquisition. Methods: A case-control stud

Multiconfigurational pair-density functional theory (MC-PDFT) offers a promising solution to the challenges faced by traditional density functional theory (DFT) in addressing molecular systems containing transition metals, open-shells, or strong correlations in general. By utilizing both the density and on-top pair-density, MC-PDFT can make use of a more flexible multiconfigurational wave function

Generally, the cost of public transport has increased. Previous research has identified peak hour traffic as the main cost driver, mostly because the travel demand increases the number of vehicles and drivers needed. The purpose of this study is to identify measures aiming to reduce travel with public transport during peak hours, conducted through a semi-systematic literature review. The measures

Introduction: Head and neck squamous cell carcinoma (HNSCC) constitutes a heterogeneous group of cancers. Human papilloma virus (HPV) is associated with a subtype of HNSCC with a better response to treatment and more favorable prognosis. Mitochondrial function and metabolism vary depending on cancer type and can be related to tumor aggressiveness. This study aims to characterize the metabolism of

A mobile stroke unit (MSU) is an advanced ambulance equipped with specialized technology and trained healthcare personnel to provide on-site diagnosis and treatment for stroke patients. Providing efficient access to healthcare (in a viable way) requires optimizing the placement of MSUs. In this study, we propose a time-efficient method based on a genetic algorithm (GA) to find the most suitable am

Background: Obtaining functional sperm cells is the first step to treat infertility. With the ever-increasing trend in male infertility, clinicians require access to effective solutions that are able to single out the most viable spermatozoa, which would max out the chance for a successful pregnancy. The new generation techniques for sperm selection involve microfluidics, which offers laminar flow

The present document was issued by a diverse group of scholars on behalf of The European Association of Health Law (EAHL) Interest Group on Supranational Biolaw, and as part of Stakeholder Feedback on the current draft of General Recommendation N° 37 on racial discrimination in the enjoyment of the right to health (GR37). The EAHL Interest Group on Supranational Biolaw supports the Committee’s eff

The true promise of MXene as a practical supercapacitor electrode hinges on the simultaneous advancement of its three-dimensional (3D) assembly and the engineering of its nanoscopic architecture, two critical factors for facilitating mass transport and enhancing an electrode’s charge-storage performance. Herein, we present a straightforward strategy to engineer robust 3D freestanding MXene (Ti3C2T

The predator functional response quantifies the per capita feeding rate of predators as a function of prey density and is a key element of feeding interactions. Variations in its parameters are strongly associated with interaction strength and population dynamics. We examined 18 functional responses within marine whelk−bivalve systems, varying predator body size, prey species, and habitat structur

The pre-tetramerization loop (PTL) of the human tumor suppressor protein p53 is an intrinsically disordered region (IDR) necessary for the tetramerization process, and its flexibility contributes to the essential conformational changes needed. Although the IDR can be accurately simulated in the traditional manner of molecular dynamics (MD) with the end-to-end distance (EEdist) unhindered, we sough

Most studies have been carried out to investigate the surface integrity induced by metal cutting process. However, the previous studies are limited to a longitudinal turning or orthogonal cutting operations and the residual stresses generated in a fillet radius have been ignored. This study uses a combination of experiments and numerical simulations to study the evolution of cutting forces, temper

Alpine ecosystems harbor remarkably diverse and distinct plant communities that are characteristically limited to harsh, and cold climatic conditions. As a result of thermal limitation to species occurrence, mountainous ecosystems are considered to be particularly sensitive to climate change. Our understanding of the impact of climate change is mainly based on vascular plants however, whereas cryp

Hemostasis is a dynamic process that starts in utero. Neonates, especially those who are born preterm, are at high risk of bleeding. The coagulation system evolves with age, and the decreased levels of coagulation factors along with hypo-reactive platelets are counterbalanced with increased activity of von Willebrand factor, high hematocrit and mean corpuscular volume as well as low levels of coag

N-type doping of the bulk-heterojunction layer in nonfullerene organic solar cells allows to effectively ameliorate inferior electron transportation by filling traps and optimizing electron pathways, leading to a better balance of charge transport in device. This mechanism, however, provides an incomplete understanding of the stronger photogeneration, long-lived excitons and simultaneously increas

Background: The association between protein intake and prostate cancer risk remains unclear. Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid int

Artikeln undersöker temporal styrning i den svenska asylbyråkratin genom en kvalitativ analys av tio familjers asylakter. Dessa består av över 5 000 sidors dokumentation: asylutredningsprotokoll, beslut, domar, intyg, överklaganden, inlagor, personliga brev, minnesnoteringar med mera. Studien fokuserar särskilt på Migrationsverkets beslut och de muntliga utredningar som myndighetens handläggare ha

Patients who undergo heart transplantation (HT) have increased loss of bone mineral density (BMD) [g/cm2]. The greatest drop in BMD occurs within the first year after HT with a decrease 3.5-8.5% in the lumbar spine and 5.6-10.5% in the femoral neck. Thereafter, BMD tend to stabilize or even recover to some degree. Accordingly, risk of fracture correlates to BMD evolution, with the highest rate of

Peberholm is a constructed Danish island in the Øresund strait. It was primarily constructed by calcareous clay from the sea floor, and is traversed by a highway and a railway. Being constructed from material without a seed bank, Peberholm constituted a good opportunity to study primary succession in an anthropogenic context. In this study, data from a survey of the vascular plant community of Peb

Previous research shows that wars contributed to the expansion of state revenues in the Early Modern period and in the twentieth century. There are, however, few cross-national studies on the long nineteenth century. Using new unbalanced panel data on wars and public revenues from 1816 to 1913 for 27 American and European countries, this article provides new evidence that military conflicts very r