The environmental and food contaminant, benzo[a]pyrene {B[a]P, a polycyclic aromatic hydrocarbon (PAH)}, is classified as a human carcinogen by the International Agency for Research on Cancer. The carcinogenicity of B[a]P is linked to the formation of electrophilic metabolites, namely B[a]P-diol epoxides (BPDEs) occurring as stereoisomers. In this work, we quantified the metabolic formation of BPD

Background: A warmer climate has consequences for the timing of phenological events, as temperature is a key factor controlling plant development and flowering. In this study, we analyse the effects of the long-term climate change and an extreme weather event on the first flowering day (FFD) of five spring-flowering wild plant species in the United Kingdom. Citizen science data from the UK Woodlan

This paper adds to critical studies of risk and mothering by illustrating and conceptualising how risk is constructed in public health advice and mothers’ accounts of weaning. Previous research points towards a gap between public health scientific definitions of risk and mothers’ contextual understandings and experience of handling complex and often conflicting risks linked to food and feeding. It

We conduct a contest experiment to study if spread seeking and effort can be managed when participants can invest in increasing both the mean and the spread of an uncertain performance variable. Subjects are treated with different prize schemes and in accordance with theory, we observe higher investments in spread for the winner-take-all scheme. Both types of investments can be controlled with a t

Background: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been reported although with drawbacks related to competition with CI. In contrast to ScNDI1, which is perm

Molecular changes occurring during invasion and clinical progression of cancer are difficult to study longitudinally in patient-derived material. A unique feature of urothelial bladder cancer (UBC) is that patients frequently develop multiple nonmuscle invasive tumors, some of which may eventually progress to invade the muscle of the bladder wall. Here, we use a cohort of 73 patients that experien

Co-housing is often lauded as an alternative housing form offering a more socially, ecologically and economically sustainable way of living. This book takes its departure in the need for a critical exploration of co-housing in the context of sustainable urban development, beyond the normative approach that often characterizes co-housing research. Based on a four-year research project involving in-

Under efterkrigstiden skakades Stockholm återkommande av så kallade ungdomsupplopp, som av samtidens makthavare förstods som opolitiska, ja näst intill meningslösa i sin obegriplighet. Samtidigt låter händelserna oss resonera kring förhållandet mellan det offentliga rummet och människors kollektiva aktörskap. Genom att närma sig upploppen utifrån den politiska filosofen Jacques Rancières teorier o

The voltage-controlled graphene-mediated surface-enhanced Raman scattering (G-SERS) spectroscopy is experimentally developing spectral technology, and which is prosperously applied in the fields of ultra-sensitive spectral analysis, sensor and catalysis. In this review, we introduce the physical principle, fabrication method, and recent applications of voltage-controlled G-SERS. We firstly introdu

Det ökande byggandet av stadsvägtunnlar, de alpina tunnelolyckorna runt millennieskiftet, och det efterföljande EU-direktiv (2004/54/EC) med minimikrav gällande brandsäkerhet har placerat brandsäkerhet i vägtunnlar högt på dagordningen. Samtidigt är moderna enkelriktade vägtunnlar ofta bland de säkraste delarna av vägsystemet. Har vi kommit till en punkt där resurserna används bättre någon annanstThis thesis can be described as a journey in performance-based fire safety design. Along the way questions such as what fire safety is, how it can be measured, whether we are posing the right questions, or engineer the best solutions, have arisen. The safety journey naturally started out with the traditional view, with fire safety engineering based on limit-based design. Using this paradigm the sa

Post-translational methylation of lysine side chains is of great importance for protein regulation, including epigenetic control. Here, we present specific 13CHD2 labeling of dimethylated lysines as a sensitive probe of the structure, interactions, and dynamics of these groups, and outline a theoretical and experimental framework for analyzing their conformational dynamics using 1H and 13C CPMG re

Parental care in birds varies among species and geographic regions. Incubation behavior influences embryonic development rate and varies substantially among species. We studied attendance at the nest by videoing nests or collecting data from the literature for 112 species in north temperate and lowland tropical sites, then associated patterns of incubation on- and off-bouts with species and enviro

Aims: To predict irreversible reduction in left ventricular ejection fraction (LVEF) during admission for ST-segment elevation myocardial infarction (STEMI) using cardiac magnetic resonance (CMR) in addition to classical clinical parameters. Irreversible reduction in LVEF is an important prognostic factor after STEMI which necessitates medical therapy and implantation of prophylactic implantable c

Activation of polymorphonuclear leukocytes (PMNs) and adhesion to the endothelial lining is a major cause of edema formation. Although known to be dependent on the function of β2 integrins (CD11/CD18), the precise mechanisms by which adherent PMNs may impair endothelial barrier capacity remain unclear. Here, the role of transmembrane signaling by β2 integrins in PMN-induced alterations in tight ju

Human high molecular mass kininogen (HK) participates as nonenzymatic cofactor in the contact system. Here, we show that recombinant domain D5 of HK (rD5) prolongs the clotting time of the intrinsic pathway of coagulation and attenuates the generation of bradykinin. Further studies indicate that a correct fold of domain D5 within HK is required for the activation of the contact system. The folding