In the last decade, organoid technology has filled the gap generated by the poor accessibility and unique features of the human brain. Organoids present several advantages in comparison with two-dimensional culturing, since they recapitulate cytoarchitecture in space and functionality of the tissue. Therefore, they mimic the unique features of human brain better than animal models. Although signif

Background: Measuring the patients’ experience of care at an outpatient clinic can provide feedback about the quality of health care and if needed, can be support for quality improvements. To date, there is no patient reported experience measurement (PREM) developed targeting patients at the pulmonary arterial hypertension (PAH) outpatient clinics. Therefore, the aim was to develop and evaluate th

Self-propagating, amyloidogenic mutant huntingtin (mHTT) aggregates may drive progression of Huntington's disease (HD). Here, we report the development of a FRET-based mHTT aggregate seeding (FRASE) assay that enables the quantification of mHTT seeding activity (HSA) in complex biosamples from HD patients and disease models. Application of the FRASE assay revealed HSA in brain homogenates of presy

This thesis experimentally investigates the possibilities of using quantum effects in semiconductor nanostructures for engineering their thermoelectric properties. More specifically, heterostructured InAs/InP nanowires are used to create short InAs quantum dots (QDs) with electronic state structure resembling that found in atoms. Recently developed top-heater architecture is used to apply a temper

We predict bond betas conditioning on a number of macro-finance variables. We explore differences across long-term government bonds, investment grade corporate bonds, and high yield corporate bonds. We conduct out-of-sample forecasting using the new approach of combining predictor variables through complete subset regressions (CSR). We consider the robustness of CSR forecasts across the 1-month, 3

Most studies reporting bleedings in patients with ST-segment elevation myocardial infarction (STEMI) are reports from clinical trials, which may be unrepresentative of incidences in real-life. In this study, we investigated 1-year bleeding and mortality incidences in an unselected STEMI population, and compared participants with nonparticipants of a randomized all-comer clinical trial (The Third D

Context: Pulmonary arterial hypertension (PAH) affects people of all ages and is associated with poor prognosis. Chronic breathlessness affects almost all people with PAH. Objectives: This randomized, placebo-controlled, double-blind, crossover study aimed to evaluate the effects of regular, low-dose, extended-release (ER) morphine for PAH-associated chronic breathlessness. Methods: Participants w

The coastal cliffs in Klaksvík (Borðoyar Bay) are the only known locality with Eemian sediments in the Faroe Islands. Previous studies carried out there focused on the sedimentology, tephra chemistry, paleoecology including aquatic environment, or the age of the deposits. In the lacustrine, clayey to silty gyttja we collected scattered wood fragments, identified as Larix sp., Pinus sp., Taxus sp.

Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient isc

This study investigated the potential loss expected from marker-assisted selection (MAS) when only a proportion of animals are genotyped using several selective genotyping strategies. A population resembling a commercial dairy cattle population over 25 yr was simulated, and the most informative individuals for genotyping were identified among the potential breeding candidates (young bulls and bull

Mechanisms of gender ratio in progeny are complex and the fine details are still largely unknown, even in mammals. Though the 50% ratio of males and females is expected, various factors have been shown to be effective in diverting the ratio from the expected. In this study, dominance index, effects of sire, age of dam, birth type and year of birth on the gender ratio of Turkish Saanen goat kids we

A whole genome scan to map quantitative trait loci (QTL) for persistency of milk yield (PMY), persistency of fat yield (PFY), persistency of protein yield (PPY) and persistency of milk energy yield (PEY) was performed in a granddaughter design in the German Holstein dairy cattle population. The analysis included 16 paternal half-sib families with a total of 872 bulls. The analysis was carried out

Fifty-one half-sib families with 2768 sires were selected for this study to confirm a quantitative trait locus (QTL) detected within a previous project initiated by the German Cattle Breeders Federation (ADR). The data based on a granddaughter design were divided into two parts and were analysed using linear models and paternal half sib regression methods. The results strongly support the hypothes

Objectives: To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes. Research Methods and Procedures: Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat depositio

The gene, acyl-CoA:diacylglycerol acyltransferase1 (DGAT1), was recently identified as the one underlying the quantitative trait locus (QTL) for milk production traits in the centromeric region of the bovine chromosome 14. Until now, 2 alleles, the lysine variant (increasing fat yield, fat and protein percentage) and the alanine variant (increasing protein and milk yield), were postulated at DGAT1

Genes determining the bovine erythrocyte antigens were mapped by linkage analysis. In total 9591 genotypes of 20 grandsire families with 1074 sires from a grand-daughter design were elucidated for the genes determining the erythrocyte antigens EAA, EAB, EAC, EAF, EAJ, EAL, EAM, EAN′, EAR′, EAS, EAT′, and EAZ according to standard paternity testing procedures in the blood typing laboratories. Linka