Reliance on data for software systems engineering is increasing, e.g., to train machine learning applications. We foresee increasing costs for data collection and maintenance, leading to the risk of development budgets eaten up by commodity features, thus leaving little resources for differentiation and innovation. We therefore propose Open Collaborative Data (OCD) - a concept analogous to Open So

Chemogenetics is the process of genetically expressing a macromolecule receptor capable of modulating the activity of the cell in response to selective chemical ligand. This chapter will cover the chemogenetic technologies that are available to date, focusing on the commonly available engineered or otherwise modified ligand-gated ion channels and G-protein-coupled receptors in the context of neuro

Owing to their extreme crowding and high and variable extinction, stars in the Galactic Bulge, within ±2° of the Galactic plane, and especially those in the Nuclear Star Cluster, have only rarely been targeted for an analyses of their detailed abundances. There is also some disagreement about the high end of the abundance scale for these stars. It is now possible to obtain high dispersion, high S/

Introduction: The thrombin generation assay-calibrated automated thrombogram (TGA-CAT) method is used to measure the overall coagulation capacity in plasma. However, the method is still considered to be a research tool, mainly because of its’ lack of standardization. Aim: Our study aimed to further raise the standardization level for the TGA-CAT method by evaluating a detailed standardization prot

Innovation plays an important role in organization survival and longevity. This is especially true in the retail industry; there is a growing acknowledgment of the role of innovation in retail practice, as maintaining the status quo might prove insufficient, especially for traditional retailers, in addressing the enormous challenges they are facing driven by technological developments and evolving

We describe a new and model-independent Lévy imaging method of quality fits to the published datasets and reconstruct the amplitude of high-energy pp and pp¯ elastic scattering processes. This method allows us to determine the excitation function of the shadow profile P(b), the elastic slope B(t) and the nuclear phase ϕ(t) functions of pp and pp¯ collisions directly from the data. Surprisingly, no

After a spout of optimism surrounding Myanmar's so-called democratic transition in the post-2010 period, civil-society organisations and academics are beginning to highlight rampant and violent resource grabs unfolding across the country. Delving into the Northern Tanintharyi landscape in the Southeast, this article aims to understand interrelated dynamics of coastal and agrarian transformation du

Ur ett strukturcykliskt perspektiv sker en omvandling av ekonomi, institutioner och politik under omvandlingsperioderna. Då välfärd kan betraktas som en funktion av dessa borde det vara möjligt att analysera välfärd och de institutionella arrangemang som är nödvändiga för en välfärdsproduktion med hjälp av en strukturcyklisk ansats. Lennart Schön har i ett flertal studier diskuterat detta samband,

Hypertension is considered the major modifiable risk factor for the development of cognitive impairment. Because increased blood pressure is often accompanied by an activation of the immune system, the concept of neuro-inflammation gained increasing attention in the field of hypertension-associated neurodegeneration. Particularly, hypertension-associated elevated circulating T-lymphocyte populatio

Great hopes have been placed in the sharing economy to provide a new business model based on peer-to-peer (P2P) exchanges of underutilized assets. As a model, the sharing economy has been expected to make significant contributions to sustainability, providing new opportunities for entrepreneurship, more sustainable use of resources, and consumer co-operation in tight economic networks. However, in

Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. The management of AD must consider the clinical and pathogenic variabilities of the disease

Microbial decomposers are responsible for the breakdown of organic matter (OM) and thus regulate soil carbon (C) stocks. During the decomposition of OM, microorganisms can use the assimilated C for biomass production or respire it as CO2, and the fraction of growth to total assimilation defines the microbial carbon-use efficiency (CUE). As such, CUE has direct consequences for how microbial decomp

The porous aquifers in the area called Challapampa are the most important groundwater reservoirs that supply drinking water to Oruro city in the highlands of Bolivia. They consist of unconsolidated fluvial–lacustrine deposits, resting on a complex sedimentary bedrock and covered by a thin surficial clay layer. The settings of these geological units and the structures governing the flow patterns ha

Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that the PDZ-binding motif of Claudin-2 is necessary for anchorage-independent growth of cancer cells and is required for liver metastasis. Several PDZ domain-containing proteins were identified that interact with the PDZ-binding motif of Claudin-2 in liver metastatic breast can

Sedan slutet av 1970-talet har Kina upplevt en anmärkningsvärd socioekonomisk utveckling. Tendensen till marknadifiering och modernisering försvagade kulturellt rotade livsstilar och allt fler etniska minoritetsgrupper i Kina har börjat betrakta traditionell kultur som irrelevant för deras försörjning och framtid samt i viss utsträckning också har börjat ta avstånd från dessa. Detta utgör ett hot Since the late 1970s, China has experienced remarkable socioeconomic development. The trend towards marketisation and modernisation overturned culturally-rooted lifestyles, and more and more ethnic minorities in China have started to regard their traditional cultures as irrelevant to their livelihoods and future and chosen to move away from them. This poses a threat to the idea of ethnic diversity

It is known that any harmonic map of finite uniton number from a Riemann surface into U (n) can be deformed into a new harmonic map with an associated S1-invariant extended solution. We study this deformation in detail using operator-theoretic methods. In particular, we show that the corresponding unitons are real analytic functions of the deformation parameter, and that the deformation is closely