The emergence of COVID-19 has changed the world as we know it, arguably none more so than for older people. In Sweden, the majority of COVID-19-related fatalities have been among people aged ⩾70 years, many of whom were receiving health and social care services. The pandemic has illuminated aspects within the care continuum requiring evaluative research, such as decision-making processes, the stru

As more people are surviving cardiac arrest, focus needs to shift towards improving neurological outcomes and quality of life in survivors. Brain injury after resuscitation, a common sequela following cardiac arrest, ranges in severity from mild impairment to devastating brain injury and brainstem death. Effective strategies to minimise brain injury after resuscitation include early intervention w

PURPOSE: Recent studies demonstrated reduced cardiovascular (CV) risk with gonadotropin-releasing hormone (GnRH) antagonist, yet the underlying mechanism remains undetermined. The objective of this study was to examine longitudinal changes over time in established CV related proteins among men treated with GnRH agonists vs GnRH antagonist. MATERIALS AND METHODS: We performed a proteomics analysis

Climate during the Last Interglacial period (LIG, Marine Isotope Stage 5e) was on average warmer than the present, with a higher global sea level but also more unstable conditions. Today, the Baltic Sea interacts strongly with conditions in the North Atlantic region, and this interaction was likely even stronger during the LIG. We here present a reconstruction of seawater conditions during the LIG

The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. Here, we identify a KRAB-ZFP transcription factor, ZNF558, that is expressed in human but not chimpanzee forebrain neural progenitor cells. ZNF558 evolved as a suppressor of LINE-1 tran

In this paper we target the color transfer estimation problem, when we have pixel-to-pixel correspondences. We present a feature-based method, that robustly fits color transforms to data containing gross outliers. Our solution is based on an optimal inlier maximization algorithm that maximizes the number of inliers in polynomial time. We introduce a simple feature detector and descriptor based on

SKINNY is a lightweight tweakable block cipher which received a great deal of cryptanalytic attention due to its elegant structure and efficiency. Despite the cryptanalytic efforts the security margins are remaining high. This has led to SKINNY being used as a component of multiple submissions in the NIST Lightweight Competition, an effort to standardize a lightweight AEAD scheme. Inspired by the

Within Iran, the Zagros Mountains show high biodiversity, with a wealth of endemic species. One of these is the geometrid moth Somatina wiltshirei Prout, 1938, originally described from Iran and Iraq. In the present study, one mitochondrial and up to nine protein-coding nuclear gene regions were used along with a comparative morphological examination to investigate the systematic position of this

Med hjälp av det omvända klassrummets pedagogik och digitala verktyg kan man frigöra både lärar- och studentresurser och därmed effektivera undervisningen. Akademisk humaniora ställer dock särskilda krav på såväl digitala verktyg som på det omvända klassrummets övningsmoment. Bägge kräver tillämpningar som skiljer sig från andra discipliner. Vad gäller de digitala utmaningarna har vi å ena sidan s

METTL13 (also known as eEF1A‐KNMT and FEAT) is a dual methyltransferase reported to target the N‐terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13‐mediated methylation of eEF1A has functional consequences related to translation dynamics and include altered rate of global protein synthesis and translation of specific codons. Aberrant regulation of METTL13 h

Active galactic nuclei (AGNs) are very powerful galaxies characterized by extremely bright emissions coming from their central massive black holes. Knowing the redshifts of AGNs provides us with an opportunity to determine their distance to investigate important astrophysical problems, such as the evolution of the early stars and their formation, along with the structure of early galaxies. The red

Two-particle Azimuthal correlations are measured with the ALICE apparatus in pp collisions at s=13 TeV to explore strangeness- and multiplicity-related effects in the fragmentation of jets and the transition regime between bulk and hard production, probed with the condition that a strange meson (KS0) or baryon (Λ) with transverse momentum pT> 3 GeV/c is produced. Azimuthal correlations between kao

The influence of personality factors, school achievement goals, academic efficacy, and stressload of serious problems on final grades was studied by giving a questionnaire, The Perceived Stress and Control Assessment Scale, to 915 Swedish high school students. A new measure, Stressload Index, was created by extending the Control-Stress Index. Structural Equation Modeling analysis revealed that the

We study residual polynomials, Rx0,n(e), e⊂ R, x∈ R\ e, which are the degree at most n polynomials with R(x) = 1 that minimize the sup norm on e. New are upper bounds on their norms (that are optimal in some cases) and Szegő–Widom asymptotics under fairly general circumstances. We also discuss several illuminating examples and some results in the complex case such as root asymptotics, a universal

Background Alcohol use disorder (AUD) is clinically heterogeneous. We examine its potential genetic heterogeneity as a function of sex, age, clinical features and mode of ascertainment. Methods In the Swedish population born 1932-1995 (n = 5 829 952), we examined the genetic risk profiles for AUD, major depression (MD), anxiety disorders, bipolar disorder, drug use disorder (DUD), attention defici

PREMIERE: Premiered by Hu Liu during the 2017 China-ASEAN Music Week at the Guangxi University of the Arts on May 28th.NOTE:Imitating the Vivacity of the Human Voice, is a meditation on diversity and the roiling of coexistence. In this piece disparate components from east and west do not suggest a transcendent unification. Rather, rhetorical devices such as “Tiaogong” [跳弓] or “Schleifer” become so