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The Cedell method (cerclage wire and staple) leads to less reoperations than the AO method.

Background and purpose - Fractures of the lateral malleolus often require open reduction and internal fixation (ORIF). Despite uneventful fracture healing, many patients will suffer from long-term detriments after ORIF, such as local tenderness that requires hardware removal. In Sweden, there are 2 major fixation methods, either the AO method (plate and screws) or the Cedell method (cerclage wire

Recurrent PRDM10 Gene Fusions in Undifferentiated Pleomorphic Sarcoma.

Purpose: Undifferentiated pleomorphic sarcoma (UPS) is defined as a sarcoma with cellular pleomorphism and no identifiable line of differentiation. It is typically a high-grade lesion with a metastatic rate of about 1/3. No tumor-specific rearrangement has been identified and genetic markers that could be used for treatment stratification are lacking. We performed transcriptome sequencing (RNA-Seq

Effect of heat tretment and homogenization on the rheological properties of aqueous parsnip suspensions

Parsnip (Pastinaca sativa) suspensions, at concentrations corresponding to a dilute and concentrated regime, were subjected to pasteurization, and heat treatments that favored beta-elimination reactions and pectin methyl esterase activity. The different heat treatments were combined with homogenization. Physicochemical properties such as content of insoluble/soluble material and insoluble/soluble

Supercritical Fluid Extraction and Chromatography of Lipids in Bilberry.

A supercritical fluid extraction (SFE) method has been developed for the extraction of lipids in bilberry. Experimental design was used to optimize pressure, temperature and extraction time using CO2 as solvent. Best SFE condition for total lipids was 450 bar, 60 °C and 45 min. The SFE method was compared to conventional Bligh & Dyer (B&D) extraction. The amount of fatty acid methyl esters

Late Acheulean technology and cognition at Boxgrove, UK

The Acheulean industrial complex combines technological variability with continuity on a scale unparalleled by more recent industries. Acheulean variability includes a widely recognized increase in biface refinement from the Early to Late Acheulean, however the specific timing and technological nature of this shift remain unclear as do its behavioral, cognitive, and evolutionary implications. To i

Thrombolysis in the developing world: is there a role for streptokinase?

Intravenous thrombolysis with tissue plasminogen activator is the only proven acute therapy for ischemic stroke. This therapy has not been translated into clinical practice in the developing world primarily due to economic constraints. Streptokinase, a lower cost alternative thrombolytic agent, is widely available in developing countries where it is utilized to treat patients with acute coronary s

Accuracy and Sensitivity of Parkinsonian Disorder Diagnoses in Two Swedish National Health Registers

Background: Swedish population-based national health registers are widely used data sources in epidemiological research. Register-based diagnoses of Parkinson's disease have not been validated against clinical information. Methods: Parkinson's disease (PD) and other parkinsonian disorder diagnoses were ascertained in two registers, i.e. the National Patient Register (NPR) and the Cause of Death Re

Extended structure tensors for multiple directionality estimation

Standard structure tensors provide a robust way of directionality estimation of waves (or edges) but only for the case when they do not intersect. In this work, a structure tensor extension using a one-way wave equation is proposed as a tool for estimating directionality in seismic data and images in the presence of conflicting dips. Detection of two intersecting waves is possible in a two-dimensi

Comparison of Decision Making Strategies for Self-Optimization in Autonomic Computing Systems

Autonomic computing systems are capable of adapting their behavior and resources thousands of times a second to automatically decide the best way to accomplish a given goal despite changing environmental conditions and demands. Different decision mechanisms are considered in the literature, but in the vast majority of the cases a single technique is applied to a given instance of the problem. This

Optogenetic Control of Pancreatic Islets.

In light of the emerging diabetes epidemic, new experimental approaches in islet research are needed to elucidate the mechanisms behind pancreatic islet dysfunction and to facilitate the development of more effective therapies. Optogenetics has created numerous new experimental tools enabling us to gain insights into processes little was known about before. The spatial and temporal precision that

Waste Heat Recovery from the European Spallation Source Cryogenic Helium Plants - Implications for System Design

The European Spallation Source (ESS) neutron spallation project currently being designed will be built outside of Lund, Sweden. The ESS design includes three helium cryoplants, providing cryogenic cooling for the proton accelerator superconducting cavities, the target neutron source, and for the ESS instrument suite. In total, the cryoplants consume approximately 7 MW of electrical power, and will

Soluble amyloid precursor protein alpha and beta in CSF in Alzheimer's disease

Objective: Cerebral accumulation of amyloid beta (A beta) is a pathological hallmark of Alzheimer's disease (AD). Proteolytic processing of amyloid precursor protein (APP) by alpha- or beta-secretase results in two soluble metabolites, sAPP alpha and sAPP beta, respectively. However, previous data have shown that both alpha- and beta-secretase have multiple cleavage sites. The aim of this study wa

Kinesin Light Chain 1 Gene Haplotypes in Three Conformational Diseases

A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mechanism for age-related diseases characterised by protein aggregation. Here, we hypothesise that common genetic variation in the transport protein kinesin may inf

What counts as a reasonable extent? - a systems approach for understanding fire safety in Sweden

Swedish legislation requires that any owner or user of a building maintain a reasonable level of fire protection measures to ensure the safety of all people located in the building. If a building, in the wake of a fire, in court is determined not to have had a reasonable fire protection, the blame will likewise be assigned to the building owner or user. Using the perspective of risk governance, th

Pharmaceuticals and personal care products (PPCPs) in treated wastewater discharges into Charleston Harbor, South Carolina

This study assessed seasonal and regional trends of pharmaceuticals and personal care products (PPCPs) detected in monthly samples from two local wastewater treatment plants (WWTPs) in Charleston, South Carolina, USA, over the period of one year. Surface water of Charleston Harbor was also analyzed to examine environmental distribution in an estuarine ecosystem. Of the 19 compounds examined, 11 we

In situ studies of the oxidation of HCl over RuO2 model catalysts: Stability and reactivity

Structure-activity experiments were performed for the HCl oxidation reaction (Deacon-like process) over RuO2 model catalysts - RuO2(1 1 0) and RuO2(1 0 0) - applying in situ surface X-ray diffraction (SXRD) combined with on-line mass spectrometry. The studied model catalysts turned out to be long-term stable under reaction conditions with gas feed ratios p(HCl):p(O-2) ranging from 1:4 to 4:1 in th

An epigenetic mechanism for high, synergistic expression of indoleamine 2,3-dioxygenase 1 (IDO1) by combined treatment with zebularine and IFN-γ: Potential therapeutic use in autoimmune diseases.

IDO1 can be induced by interferon gamma (IFN-γ) in multiple cell types. We have earlier described that the DNA methyltransferase inhibitor zebularine also induces IDO1 in several rat cell clones. We now describe a synergistic induction of IDO1 expression by IFN-γ and zebularine. To elucidate the mechanism of the IDO1 induction we have studied the methylation status in the promoter region of the ID

Mathematical modeling and statistical analysis of calcium-regulated insulin granule exocytosis in beta-cells from mice and humans.

Insulin is released from pancreatic beta-cells as a result of Ca(2+)-evoked exocytosis of dense-core granules. Secretion is biphasic, which has been suggested to correspond to the release of different granule pools. Here we review and carefully reanalyze previously published patch-clamp data on depolarization-evoked Ca(2+)-currents and corresponding capacitance measurements. Using a statistical mi

Word accents and morphology - ERPs of Swedish word processing

Results are presented which indicate that high stem tones realizing word accents activate a certain class of suffixes in on-line processing of Central Swedish. This supports the view that high Swedish word accent tones are induced onto word stems by particular suffixes rather than being associated with words in the mental lexicon. Using Event-Related Potentials, effects of mismatch between word ac