Sökresultat

Cardiovascular disease (CVD) is the leading cause of death globally. In the European Union (EU) alone, CVD accounts for 1.8 million deaths each year. CVD is a group of disorders involving the heart and the blood vessels. The main risk factors of CVD include unhealthy lifestyles, tobacco smoking, and obesity. It has been demonstrated that chronic high blood pressure (medically termed hypertension)

Diagnostic measurement of electric skin conductivity (ESC) called the Ryodoraku system was introduced in mid 1950s by Nakatani. As has been shown by Ziobro et al. in case of infantile cerebral palsy, changes of ESC may provide a valuable electrophysiological parameter for monitoring a therapy. In this study ESC was measured in asthmatic children treated with a bioelectronic unit VEGA-SELECT. Analy

In the setting of transplantation, T cells are deliberately depleted to prevent allograft rejection. However, this IL-7 activates the accelerated proliferation of effector memory T cells, which are the predominant mediators of graft rejection. Multipotent adult progenitor cells (MAPC) have been previously shown to modulate the response of T cells to IL-7, in vitro but not in vivo. Here, for the fi

In the formulation of an active enzyme enclosed in a matrix for controlled delivery, it is a challenge to achieve a high protein load and to ensure high activity of the protein. For the first time to our knowledge, we report the use of a highly swollen lipid sponge (L3) phase for encapsulation of the large active enzyme, β-galactosidase (β-gal, 238 kDa). This enzyme has large relevance for applica

Background:Commonly used islet transplantation protocols experiencesignificant islet injury and graft loss; therefore new methods to support thelong-term benefits of this treatment are needed. Recent studies have shownthat non-endothelial bone marrow-derived multipotent adult progenitor cells(MAPC) possess significant immune-modulating abilities and can secreteangiogenic molecules, which could mak

OBJECTIVE: Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS: At baseline, 178 lipids were measured by mass spectrometry in 3,668 participants wit

The antimicrobial peptide LL-37 is active against oral bacteria and has been demonstrated to be present in human saliva, but its distribution in different fractions of saliva is not known. LL-37 is formed from its intracellular pro-form, hCAP18, in an extracellular enzymatic reaction catalyzed by proteinase 3 and kallikrein 5. Here, we prepared cell-containing and cell-free fractions of unstimulat

OBJECTIVE: Recent in vivo results have shown prominent tissue sparing effect of radiotherapy with ultra-high dose rates (FLASH) compared to conventional dose rates (CONV). Oxygen depletion has been proposed as the underlying mechanism, but in vitro data to support this have been lacking. The aim of the current study was to compare FLASH to CONV irradiation under different oxygen concentrations in

Vi vet idag att en omställning av transportsektorn är avgörande för uppfyllandet av de klimatpolitiska målen och FN:s 2030-mål. Såväl forskare som praktiker har därför framhävt behovet av att öka andelen energieffektiva transportslag som gång, cykel och kollektivtrafik. Samtidigt pågår det idag en snabb teknikutveckling inom transportområdet och idag sker mycket av innovationsarbetet genom offentl

While previous research on projectification tends to focus on why processes of projectification emerge and in what contexts, this chapter use the example of European Union (EU) project funding in Swedish local government to analyse and understand how processes of projectification unfold in terms of transformation and adaptation. Key agents in processes of projectification are located and how these

Mobility-as-a-Service (MaaS) has been argued as part of the solution to prevalent transport problems. However, progress from pilots to large-scale implementation has hitherto been slow. The aim of the research reported in this paper was to empirically and in-depth investigate how, and to what extent, different factors affect the development and implementation of MaaS. A framework was developed, wi

In the light of increasing urban challenges, municipalities are developing and advancing new forms of governing. One such example is ‘urban experimentation’, a process where city-based innovation processes are initiated to test solutions that – if deemed successful – are intended to be scaled up with the ambition to leverage a broader urban sustainability transition. Research on experimental gover

This volume is a special issue with contributions that stem from the collaborations of the 2018 AESOP PhD workshop, held 5-8 July at Tjärö island, Sweden. The overarching aim of the workshop was to establish inclusive spaces for dialogue and collaboration between PhD students across countries and continents on issues that pertained to the AESOP’s 2018 congress theme “Making space for hope”. Furthe