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RIFM fragrance ingredient safety assessment, 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile, CAS registry number 68084-04-8

The existing information supports the use of this material as described in this safety assessment. 3-(4-Methyl-3-pentenyl)-3-cyclohexene-1-carbonitrile was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 3-(4-methyl-3-pentenyl)-3-cyclohexene-1-carbon

RIFM fragrance ingredient safety assessment, phenylethyl anthranilate, CAS Registry Number 133-18-6

The existing information supports the use of this material as described in this safety assessment. Phenylethyl anthranilate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from phenylethyl anthranilate and the read-across analog cinnamyl

Extended Analysis of Age of Information Threshold Violations

We study a scenario where a monitor is interested in the freshest possible update from a remote sensor. The monitor also seeks to minimize the number of updates that exceed a certain freshness threshold, beyond which, the information is deemed to be too old. Previous work has presented results for First Come First Served (FCFS) systems. However, it has been shown that Last Come First Served (LCFS)

Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipi

Complex by design : Hydrotrope-induced micellar growth in deep eutectic solvents

Hypothesis: The self-assembly of ionic surfactants in deep eutectic solvents has recently been demonstrated, opening up new possibilities in terms of the development of formulated products and templating of nanostructured materials. As it occurs in an aqueous environment, the solvophobic effect drives the formation of micelles in these solvents and specific-ion interactions alter the resulting str

Dental care - an emotional and physical challenge for the sexually abused

The aim was to explicate persistent psychological and bodily memories of sexual abuse and how they are expressed during dental appointments. The participants comprised 13 sexually abused individuals (11 women), who recalled and expressed these experiences during a dental appointment. They were encouraged to describe, in detail, aspects of the appointment which triggered memories of the sexual abus

Orthogonal P-wave morphology, conventional P-wave indices, and the risk of atrial fibrillation in the general population using data from the Finnish Hospital Discharge Register

AIMS: Identifying subjects at high and low risk of atrial fibrillation (AF) is of interest. This study aims to assess the risk of AF associated with electrocardiographic (ECG) markers linked to atrial fibrosis: P-wave prolongation, 3rd-degree interatrial block, P-terminal force in lead V1, and orthogonal P-wave morphology. METHODS AND RESULTS: P-wave parameters were assessed in a representative Fi

Evaluation of the HAVOSS software process maturity model

The HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was condThe HAVOSS (Handling Vulnerabilities in OSS) maturity model describes important processes for managing security vulnerabilities in OSS modules in developed products. So far, the model has not been evaluated in any real assessment process. Here we present a study where the model was evaluated by using it in assessments of processes for two product types in one organization. Each assessment was cond

Benefits of Investigating the Thermal Component for Moisture Safety in Ventilated Attics

Cold ventilated attics often have mould problems in Sweden. This is valid both for old and sometimes newly built attics. Increased insulation on the attic floor is assumed to increase the problem. To investigate this, numerical 1D models like WUFI or WUFI+ are typically used. These models give results but the physical processes are not so transparent for the user due to the complex numerical techn

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol

BACKGROUND: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) but these have modest value for predicting future renal status. There is an unmet need for biomarkers that can be used in clinical settings which also improve prediction of renal declin

Trade and nationalism : Market integration in interwar Yugoslavia

This article empirically analyses the relationship between nationalism and regional economic integration in the Kingdom of Yugoslavia between the First and the Second World War. It argues that prevailing nationalism had a negative impact on the economic integration of the regions within the Kingdom and further contributed to the political disintegration of the Kingdom. The analysis implies that th

Alkaliphiles : The Emerging Biological Tools Enhancing Concrete Durability

Concrete is one of the most commonly used building materials ever used. Despite it is a very important and common construction material, concrete is very sensitive to crack formation and requires repair. A variety of chemical-based techniques and materials have been developed to repair concrete cracks. Although the use of these chemical-based repair systems are the best commercially available choi

Differentiable fixed-rank regularisation using bilinear parameterisation

Low rank structures are present in many applications of computer vision and machine learning. A popular approach consists of explicitly parameterising the set or matrices with sought rank, leading to a bilinear factorisation, reducing the problem to find the bilinear factors. While such an approach can be efficiently implemented using second-order methods, such as Levenberg-Marquardt (LM) or Varia

Low bone mineral density in adults with complex congenital heart disease

Aims: The majority of children with complex congenital heart disease (CHD) survive into adulthood due to advances in medical care. Adult patients with CHD have an increased incidence of diagnoses related to ageing such as heart failure, dementia, cancer and sarcopenia, despite a relatively low age. They also have a shorter life expectancy. It is unknown if their bone structures also show signs of

RIFM fragrance ingredient safety assessment, ethyl (E)hex-3-enoate, CAS registry number 26553-46-8

The existing information supports the use of this material as described in this safety assessment. Ethyl (E)hex-3-enoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl 3-hexenoate (CAS # 2396-78-3) show that ethyl (E)hex-3-e