Aim: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. Methods: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data

The importance of natural IgM antibodies in protection against infections is still emerging and these antibodies have a potential role in the maintenance of homeostasis through clearance of apoptotic bodies, complement-dependent mechanisms, inflammation and exclusion of misfolded proteins. Natural IgM act as a first line of defence against unknown hazardous factors and are present in most vertebra

Background: Early cardiopulmonary resuscitation (CPR) and defibrillation with an Automated External Defibrillator (AED) increase survival from out-of-hospital cardiac arrest (OHCA). Although international guidelines recommend the use of AED registries to increase AED use, little is known about implementation. The aim of this paper is to describe the development of a national AED registry, to analy

Endo-β-N-acetylglucosaminidase (EndoS) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Recombinant EndoS hydrolyzes the β-1,4-di-N-acetylchitobiose core of the N-linked complex type glycan on the asparagine 297 of the γ-chains of IgG. Here, we report that EndoS and IgG hydrolyzed by EndoS induced suppression of local immune complex (IC)-mediated arthritis. A small amount (1 µ

During a meeting held in Trento, Italy in March 2017, and organised by the COST Action CHIP ME (IS1303) to discuss about ELSI of genome-editing, many different positions emerged on the possibility to intervene on reproduction and especially on the human embryo. At the time, the Nuffield Council on Bioethics had commissioned a background paper on genome editing, and the corresponding Working Group

Background: Malaria parasites and related haemosporidian parasites are widespread and may cause severe diseases in birds. These pathogens should be considered in projects aiming breeding of birds for purposes of sustained ex situ conservation. Cranes are the 'flagship species' for health assessment of wetland ecosystems, and the majority of species are endangered. Malaria parasites and other haemo

Ionization mechanisms of C60 molecules irradiated by a short intense 800-nm laser pulse are studied. Angle-resolved photoelectron spectra show above-threshold ionization (ATI) patterns with a low peak contrast and a remarkably smooth angular distribution. The results are interpreted by combining two theoretical models. A time-dependent Schrödinger equation (TDSE) calculation based on the B-spline

To meet multiple environmental objectives, integrated programming is becoming increasingly important for the Global Environmental Facility, the financial mechanism of the Multilateral Environmental Agreements, including the UN Convention to Combat Desertification. However, integration is often not well defined. We therefore focus on identifying key aspects of integration and assessing their implem

The inclusive and fiducial tt¯ production cross-sections are measured in the lepton+jets channel using 20.2fb-1 of proton–proton collision data at a centre-of-mass energy of 8 TeV recorded with the ATLAS detector at the LHC. Major systematic uncertainties due to the modelling of the jet energy scale and b-tagging efficiency are constrained by separating selected events into three disjoint regions.

Presented here is an engineered protein domain, based on Protein A, that displays a calcium-dependent binding to antibodies. This protein, ZCa, is shown to efficiently function as an affinity ligand for mild purification of antibodies through elution with ethylenediaminetetraacetic acid. Antibodies are commonly used tools in the area of biological sciences and as therapeutics, and the most commonl

This article presents and analyses the judgment of the Grand Chamber of the eu Court of Justice of 17 October 2017 in the case of Bolagsupplysningen v. Svensk Handel (Case C-194/16), which represents a new development regarding the application of eu jurisdictional rules to disputes arising out of alleged violations of personality rights on the internet.

Endoscopic retrograde cholangiopancreatography (ERCP) was introduced 5 decades ago in 1968. Since then ERCP has redefined treatment of pancreatic and biliary tract diseases. The modern duodenoscopy was invented in 1970. Initially, ERCP was mainly used for diagnostic purposes. Sphincterotomy was introduced 1974, which made surgery obsolete in the management of cholodocholitiasis. In 1980 were the f

New nanoarchitectures can be built from polycyclic aromatic hydrocarbons (PAHs) by exploiting the capability of some metal surfaces for inducing cyclodehydrogenation reactions. This bottom-up approach allows the formation of nanostructures with a different dimensionality from the same precursor as a consequence of the diffusion and coupling of the PAHs adsorbed on the surface. In this work we pres

This article tests for wage discrimination in US manufacturing during the nineteenth century and in 2002 by estimating the female-to-male productivity ratio and comparing it to the wage ratio. This method will not identify all forms of discrimination, but will determine whether women were paid wages commensurate with their productivity. There was no significant difference between the wage ratio an

We qualitatively analysed how and why environmental improvement actions often lead to unintended environmental consequences. Different theories are integrated to delineate the underlying system structure causing this system behavior. Causal loop diagram technique is utilized to explore and visualize: how incremental improvements in material and energy efficiency can unintendedly cause consumption

This introduction to the special issue, ‘Engagement, Witnessing and Activism: Independent Chinese Documentary Filmmakers’ Different Positions, Approaches and Aesthetics,’ argues that how the political is registered and expressed in Chinese activist documentaries cannot simply be read through Western ideas, concepts and aesthetics. Rather, Chinese work has been shaped partly in relation to state-sa

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