Life-long production of blood from hematopoietic stem cells (HSC) is a process of strict modulation. Intrinsic and extrinsic signals govern fate options like self-renewal – a cardinal feature of HSC. Bone morphogenetic proteins (BMP) have an established role in embryonic hematopoiesis, but less is known about its functions in adulthood. Previously, SMAD-mediated BMP signaling has been proven dispe

Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. In the present study, we investigated whether transcriptional changes would be part of hypothalamic pathology induced by the disease-causing huntingtin (H

While family members tend to have similar labor market outcomes, measuring the contribution of behavioral spillovers is difficult. To identify spillovers between brothers, we exploit Denmark's largest random assignment of young men—to eight months of military service, where service status of brothers is correlated, but draft lottery numbers are not. We find average spillovers of elder brother serv

Garden escapes of Acer campestre spread as a cryptic invading gene pools and challenge the conservation of a unique ancient population in southern Scandinavia. The native gene pool consists of just 34 individuals and is listed as critically endangered. This population is more than 150 years old and represents a unique diorama into an almost extinct genetic diversity of the early 19th century. That

This mini-review presents the structural investigations of the self-assembled peptide nanotubes using X-ray scattering techniques. As compared to electron microscopy, scattering methods enable studies of nanotubes in solution under the appropriate physicochemical conditions and probe their formation mechanism. In addition, a combination of X-ray scattering methods allow the elucidation of structur

Homelessness and other forms of destitution among asylum-seeking migrants are currently on the rise across Europe, as migrants’ access to social rights, including housing, has been restricted through repressive migration policies, fuelled by the welfare nationalism and chauvinism that surge among European states. This article explores the largely overlooked homelessness experienced by migrants seeHomelessness and other forms of destitution among asylum-seeking migrants are currently on the rise across Europe, as migrants’ access to social rights, including housing, has been restricted through repressive migration policies, fuelled by the welfare nationalism and chauvinism that surge among European states. This article explores the largely overlooked homelessness experienced by migrants see

Severe Covid-19 has a high mortality rate. Vital organ dysfunction results from pathophysiological self-amplifying loops of innate immunological hyperactivation, cytokine release, complement deposition, endothelial damage, and macro- and microvascular thromboembolism. Resulting alveolar exudation and pulmonary capillary thromboembolism lead to ventilation-perfusion mismatch, considered to be a pri

Aims: Certain autoimmune diseases (ADs), such as Crohn's disease and celiac diseases, have been linked to acute cardiovascular disorders. We examined whether there is an association between 43 different ADs and risk of subsequent hospitalization and mortality of cardiomyopathy in a nationwide follow-up study in Sweden. Methods and results: All individuals in Sweden hospitalized with a main diagnos

Quantum dots (QDs) form a promising family of nanomaterials for various applications in optoelectronics. Understanding the details of the excited-state dynamics in QDs is vital for optimizing their function. We apply two-color 2D electronic spectroscopy to investigate CdSe QDs at 77 K within a broad spectral range. Analysis of the electronic dynamics during the population time allows us to identif

This chapter provides a historical overview of the development of Middle East diaspora studies and outlines the main themes within the field. Following the overview, the chapter introduces the edited volume by outlining the main arguments of each of the contributions and the ways the different chapters connect to a larger thematic argument within the field of Middle East diaspora studies.

This thesis investigates ultracold bosonic systems using an extended mean-field formalism with a focus on their superfluid and supersolid properties. The dissertation comprises five chapters and four articles, where the chapters provide some background to the research put forward in articles.Paper I demonstrates the existence of multiple singly-quantized vortices in two-dimensional droplets made o