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The receptor tyrosine kinase c-Kit, also known as the stem cell factor receptor, plays a key role in several developmental processes. Activating mutations in c-Kit lead to alteration of these cellular processes and have been implicated in many human cancers such as gastrointestinal stromal tumors (GISTs), acute myeloid leukemia (AML), testicular seminomas and mastocytosis. Regulation of the cataly

A comparison has been carried out between standard-dose computed tomography, non-diagnostic computed tomography and digital radiography with respect to their suitability for detecting radioactive fragments associated with nuclear or radiological events such as debris from radiological dispersal devices. The purpose was to investigate if radiographic imaging is justified for the detection and local

Locust bean gum (LBG) and modified starches are commonly used as thickeners in food products for infants. However, there is no consensus on their possible effects on infant nutrition, especially on mineral availability. The aim of the present work was to characterize the effect of LBG, cross-linked, hydroxypropylated maize starch (Mhdp) and pre-gelatinized rice starch (gRS) on Ca, Fe and Zn availa

Allopatry and allopatric speciation can arise through two different mechanisms: vicariance or colonization through dispersal. Distinguishing between these different allopatric mechanisms is difficult and one of the major challenges in biogeographical research. Here, we address whether allopatric isolation in an endemic island lizard is the result of vicariance or dispersal. We estimated the amount

The land and ocean absorb on average just over half of the anthropogenic emissions of carbon dioxide (CO2) every year. These CO2 "sinks" are modulated by climate change and variability. Here we use a suite of nine dynamic global vegetation models (DGVMs) and four ocean biogeochemical general circulation models (OBGCMs) to estimate trends driven by global and regional climate and atmospheric CO2 in

Objectives: To evaluate potential sex differences and other factors associated with complications within 4 months after a hip fracture. Methods: A total of 1,915 patients. 65 years (480 men) with hip fracture were consecutively included in a prospective multicenter cohort study. A review of medical records and patient interviews according to a study protocol based on the Standardized Audit of Hip

Given a stochastic shadow map rendered with motion blur, our goal is to render an image from the eye with motion-blurred shadows with as little noise as possible. We use a layered approach in the shadow map and reproject samples along the average motion vector, and then perform lookups in this representation. Our results include substantially improved shadow quality compared to previous work and a

Pike Esox lucius in the absence of prey and conspecifics were shown to have the highest habitat-change activity during dusk and to decrease preference for complex habitats in turbid water. As the behaviours indicate routine responses in the absence of behavioural interactions, E. lucius spatio-temporal distributions should be directly affected and thereby more easily assessed and avoided by prey,

Monoterpenes are abundant in essential oil extracted from plants. These relatively small and hydrophobic molecules have shown many important biological fucntions, including antimicrobial activity and membrane penetration enhancement. The interaction between the monoterpenes and lipid bilayers is considered important to the understanding of the biological functions of monoterpenes. In this study we

Lake sediments and peat deposits from two basins on Nightingale Island (37 degrees S), in the Tristan da Cunha archipelago, South Atlantic, have been analyzed. The studies were focused on the time period 16.2-10.0 cal ka BP, determined by 36 C-14 dates from the two sequences. A wide variety of proxies were used, including pollen and diatom analyzes, biogenic silica content, C and N analyzes, stabl

The aim of the BENCHOP project is to provide the finance community with a common suite of benchmark problems for option pricing. We provide a detailed description of the six benchmark problems together with methods to compute reference solutions. We have implemented seventeen different numerical methods for these problems, and compare their relative performance. All implementations are available o

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short ti

The transmission of infrared (IR) and visible frequencies through modern energy-saving glass, due to etching of bandpass frequency-selective surfaces (FSSs), is analysed. Energy-saving glass panels employ a very thin layer of metallic oxide on one side of the ordinary glass. Due to the presence of this layer, IR waves are attenuated whereas visible wavelengths can pass through, providing good see-

A new species, Nipponoparmelia perplicata described from Korea and Russia, is segregated from N. laevior, from which it differs in having shorter and wider lobes that characteristically turn down towards the margins. The pseudocyphellae are inconspicuous, positioned along the lobe margins or on the underside. An improved description of N. pseudolaevior is presented, including new data on isidia wi

Let e⊂R be a finite union of ℓ+1 disjoint closed intervals, and denote by ω j the harmonic measure of the j left-most bands. The frequency module for e is the set of all integral combinations of ω 1,…,ω ℓ . Let {a˜n,b˜n}∞n=−∞ be a point in the isospectral torus for e and p˜n its orthogonal polynomials. Let {an,bn}∞n=1 be a half-line Jacobi matrix with an=a˜n+δan , bn=b˜n+δbn . Suppose ∑n=1∞∣δan∣2+

The team behavior literature is ambiguous about the relations between members’ interpersonal processes—task debate and task conflict—and team performance. From a social influence perspective, we show why members’ interpersonal processes determine team performance over time in small groups. Together, over time, dissenting in-group minorities who share information (via debate) with majorities, who s

Gas-phase dehydration of glycerol to acrolein is studied over tungsten and niobium oxide supported on monoclinic zirconia. Supported tungsten oxide is slightly better than supported niobia with initial yields to acrolein around 78% and 75%, respectively, at complete conversion of glycerol. No synergy is observed using mixed structures with W and Nb. The addition of oxygen to the feed has almost no

Protein synthesis has been studied for more than half a century, but the atomic details of this complex system, the ribosome, began to be revealed in 1999 and 2000 through crystallographic structure determinations. As with all biomolecular systems, the advent of atomic structures are milestones in the process of relating function to structure. During these 10 years there has been an avalanche in b