Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is known to be the main component of the LB. It has also been reported to interact with several proteins and organelles. Galectin-3 (GAL3) is known to have a

The objective of this study is to present a text-critical edition of the medieval treatise Maqāla fī l-Faṣd, ‘On Phlebotomy’, attributed to Abū Bakr Muḥammad ibn Zakariyyāʾ al-Rāzī (865-925), a prominent physician and scholar known especially for his expertise in medicine. His contributions as a distinguished medical author and devoted clinician earned him recognition in both Arabic and Latin medi

A detailed understanding of the dynamics of photoinduced processes occurring in the electronic excited state is essential in informing the rational design of photoactive transition-metal complexes. Here, the rate of intersystem crossing in a Cr(III)-centered spin-flip emitter is directly determined through the use of ultrafast broadband fluorescence upconversion spectroscopy (FLUPS). In this contr

Circulating tumor cells (CTCs) may provide a liquid biopsy approach to disease monitoring in small cell lung cancer (SCLC), a particularly aggressive tumor subtype. Yet, the prognostic role of CTCs during and after treatment in relation to baseline remains ill-defined. Here, we assessed the value of longitudinal CTC analysis and the potential of low-molecular-weight heparin (LMWH) to reduce CTC ab

Youngjae Lih’s emotional and perception-altering installation Multiplicity to Singularity, then Singularity to Multiplicity explores history as natural duration measured by light frequency, with sound, abstraction and instruments meant to represent nature’s rhythms. It stems from the way in which two industrial producers of color filters, Lee and Rosco, have coded the visible world in shades of li

The aim of this study was to develop a novel software platform for the simulation of magnetic resonance spin systems, capable of simulating a large number of spatial points (1283 ) for large in vivo spin systems (up to seven coupled spins) in a time frame of the order of a few minutes. The quantum mechanical density-matrix formalism is applied, a coherence pathway filter is utilized for handling u

This article reviews the most commonly used modern sequences designed to confront the two major challenges of in vivo magnetic resonance spectroscopy (MRS): spatial localization and metabolic specificity. The purpose of this review article is to provide a deeper and clearer understanding of the underlying mechanisms by which all modern MRS sequences operate. A descriptive explanation, consistent p

FlexPES is a soft X-ray beamline on the 1.5 GeV storage ring at MAX IV Laboratory, Sweden, providing horizontally polarized radiation in the 40-1500 eV photon energy range and specializing in high-resolution photoelectron spectroscopy, fast X-ray absorption spectroscopy and electron-ion/ion-ion coincidence techniques. The beamline is split into two branches currently serving three endstations, wit

A growing body of research suggests that the global conception of climate change is increasingly taking a justice-focus. However, the justice-framings of different actors in the UNFCCC process and their evolution have not yet been examined. We conduct a critical discourse analysis of climate justice claims of state and non-state actors in COP15, COP19, COP21 and COP24 which are key moments for cli

Food security necessitates a multifaceted strategy, ranging from social protection to providing healthy food. Change in existing food systems is needed to create a more equitable and sustainable society. Hunger is one of the significant challenges in the world that arise due to food insecurity, bad quality, food waste, and losses that leads to damage of public health. The implementation of green f

Despite the consistency with which gender differences have been found in second language motivation, little systematic research has taken place on motivation and gender to date. Permeating self-concept development, gender impacts not only current selves but also future-oriented possible selves. In construing possible selves, females tend to emphasize interdependence, meaning they invest more in in

Mental time travel lies at the frontier of research into motivational persistence in language learning (Dörnyei, 2020). This article introduces the theory of episodic future thinking (D’Argembeau, 2016, 2020), and examines the key components of autobiographical knowledge and personally important goals. With findings on the long-term goals and career aspirations of preservice English teachers as a

The Atlantic world looms large in discussions of how the modern world emerged, and what modernization was about; but there have been calls to engage with these topics from the perspective of ‘margins’. Covering large areas of Fennoscandia, the seventeenth-century Kingdom of Sweden represented a northern end of urban Europe, but also encompassed the mythical Lapland, homeland of the Sámi and of nat

Purpose: The relative roles of urinary sphincter damage, aging, and childbirth in stress urinary incontinence (SUI), have not been established. This study was performed to elucidate the roles of these factors. Methods: The study included: (1) 8 female cynomolgus monkeys (17–19 years of age and 7–8 vaginal births each); (2) six 5-year-old nulliparous monkeys with surgically created chronic urinary

Structural Health Monitoring (SHM) can provide valuable information for maintenance-related activities and post-disaster emergency management. However, as with any technological system, SHM systems can be susceptible to errors due to malfunctioning. Therefore, it is essential to assess the potential for malfunctions and the associated costs of maintenance and repair when evaluating the long-term b