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Decreased antigen presentation contributes to the ability of cancer cells to evade the immune system. We used the minimal gene regulatory network of type 1 conventional dendritic cells (cDC1) to reprogram cancer cells into professional antigen-presenting cells (tumor-APCs). Enforced expression of the transcription factors PU.1, IRF8, and BATF3 (PIB) was sufficient to induce the cDC1 phenotype in 3
This study investigates the association between individuals’ concern about contracting COVID-19 and their compliance with recommended preventive and mitigation measures, namely wearing face masks, maintaining social distancing and handwashing, in the context of the Middle East and North Africa (MENA) region. The empirical analysis is based on a panel dataset from the Combined COVID-19 MENA Monitor
Osteocytes have recently been identified as a new regulator of bone remodeling, but the detailed mechanism of their differentiation from osteoblasts remains unclear. The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. The study uses IDG-SW3 cells as a model for the differentiat
INTRODUCTION: The prognosis for patients with melanoma has improved due to better treatments in recent years and updated tools to accurately predict an individual's risk are warranted. This study aims to describe a prognostic instrument for patients with cutaneous melanoma and its potential as a clinical device for treatment decisions.METHODS: Patients with localised invasive cutaneous melanoma di
Abstract in NorweiganSammenfatning: Spørsmålet om identitet er alltid tilstedei akademiske og ikke-akad-emiskediskurser om religion og interreligiøse relasjoner: identitet som en kategori av noe som kan spigles fast, etableres ogopprettholdes ved hjelp av de"nisjonerog logikk; identitet som et spørsmål om noe stabilt og til og med rigid. Detteer viktig i overveielser omsynkretisme. I denne artikkeThe matter of identity is ever present in academic, and non-academic, discourses on religion and interreligious relations: identity as a category of something that can be nailed down, established and maintained with the help of definitions and logic; identity as a matter of something stable and even rigid. This is significant in deliberations regarding syncretism. In this paper, references are mad
A variety of complementary monies are being implemented as socio-technical instruments to move individuals into action and ignite ecological collaboration. Their starting point is the recognition that we have never been modern; that human society and nature, the economy and the environment, have never been separate spheres. Modernism may have conceptualised them as distinct fields, organising the
Objective: To assess the comparability of international ethics principles and practices used in regulating pediatric research as a first step in determining whether reciprocal deference for international ethics review is feasible. Prior studies by the authors focused on other aspects of international health research, such as biobanks and direct-to-participant genomic research. The unique nature of
This paper explores the content and style of two communicative approaches to public diplomacy intended to mitigate ideological tensions between countries. The aim of the paper is to contribute to new knowledge of public diplomacy as cultural practice by examining the characteristics of its enactment and consequences for the public debate in domestic and foreign contexts.
Synovial fluid (SF) may contain cleavage products of proteolytic activities. Our aim was to characterize the degradome through analysis of proteolytic activity and differential abundance of these components in a peptidomic analysis of SF in knee osteoarthritis (OA) patients versus controls (n = 23). SF samples from end-stage knee osteoarthritis patients undergoing total knee replacement surgery an
This study aimed to estimate the healthcare costs of kidney transplantation compared with dialysis using a propensity score approach to handle potential treatment selection bias. We included 693 adult wait-listed patients who started renal replacement therapy between 1998 and 2012 in Region Skåne and Stockholm County Council in Sweden. Healthcare costs were measured as annual and monthly healthcar
