Towards yeast as a tool for in vivo continuous evolution of TRPV1 modulators
The TRPV1 receptor (transient receptor potential vanilloid 1) is a nonspecific membrane-bound cation channel, which plays an important role in nociception and pain transmission, the nerve-response to possibly dangerous stimuli. It is known that TRPV1 can be modulated by a variety of stimuli, amongst which heat, protons and chemical compounds, such as capsaicin, are the most known activators. This
