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Structure and distribution of alpha-1-microglobulin proteins

Popular Abstract in Swedish Proteiner har en nyckelroll i praktiskt taget alla biologiska processer. Proteiner har väldigt skilda funktioner, tex. transport och lagring av ämnen, som stödmaterial i vävnad, immunförsvar, samordning av ämnesomsättningen m.m. Ett protein består av mindre beståndsdelar, så kallade aminosyror. Proteiner kan vara olika stora, beroende på hur många aminosyror de innehållThis thesis describes studies of the structure and tissue distribution of alpha-1-microglobulin (a1-m), a member of the lipocalin protein superfamily with immunosuppressive properies. It was shown that a1-m appears in human plasma in five major forms. These were identified as monomeric a1-m and covalent complexes between a1-m and IgA, prothrombin, albumin and a1-m. In addition to blood, both monom

Interfacial Properties of Lipid Liquid Crystalline Nanoparticles

Lipid liquid crystalline nanoparticles are studied for their potential as biocompatible carriers for pharmaceutical, food and cosmetic applications. Their potential as delivery vehicles is due to their nanometer size, their controllable structure and physical properties and their large carrying capacity of a wide range of molecules. This study concerns the interaction of lipid liquid crystalline

Methods for measuring physical workload with relevance for musculoskeletal disorders of neck and upper limb

Popular Abstract in Swedish Att mäta kroppsställningar och rörelser under arbete Belastningsskador är vanliga och medför höga kostnader, både för de drabbade och för samhället. Kvinnor som arbetar med repetitivt arbete, t.ex. monteringsarbete och livsmedelshantering (fiskberedning och kycklingslakt), drabbas ofta, särskilt i nacke, axlar, armar och händer. De åtgärder som genomförts på arbetsplatWork-related musculoskeletal disorders of the neck and upper limb are a major problem. Women in repetitive manual work is one large affected group. Preventive actions are hampered by the lack of knowledge regarding quantitative exposure-response relations for physical workload. The present work shows, that available electrogoniometers are, with a sampling frequency of 20 Hz, feasible for measurin

Impact of Quality Management in the Swedish Construction Process

Popular Abstract in Swedish Under senare år har företag inom byggbranschen utvecklat sitt kvalitetstänkande genom att införa kvalitetssystem för att styra byggprocessen. Många olika aktörer med olika intressen är involverade vilket gör att det är en komplex process sammansatt av en rad olika mindre processer. Kraven på kvalitetssäkring kommer ursprungligen från myndigheterna via lagstiftningen menDuring the past few years, extensive effort has been devoted to developing quality systems as an integral part of the process in the construction sector. The construction process is complex, involving many different actors with different interests. The demand for quality assurance comes primarily from central authorities via the client, but quality systems should be applied throughout the whole ch

Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation i

Study of a gas turbine combustion chamber: Influence of the mixing on the flame dynamics

The new challenge of the Gas Turbine industry is to develop new technologies for meeting electricity demand growth and reducing harmful emissions. Thus a better understanding of the combustion phenomenon and an improvement in simulation capabilities are needed. Large Eddy Simulation tools brought the hope of meeting these two conditions and enabling the design of safe and clean burners. In the pre