Objectives: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid Dexamethasone (Dex) on these responses.Design: Bovine cartilage explants were treated with either cytokines alone (10 ng/ml TNFα, 20 ng/ml IL-6, 100 ng/ml

This thesis is dedicated to the investigation of laser-plasma particle acceleration concepts. Some of the work was focused on improving electron and proton acceleration for future applications, in terms of maximizing the particle energy and minimizing the divergence of the X-ray beams. In laser wakefield acceleration, a very intense laser pulse (> 1018 W/cm2) is focused in a gas. The leading edge

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

AIM: This study investigated childhood diagnoses in children born extremely preterm before 24 weeks of gestation.METHODS: Diagnoses of neurodevelopmental disorders and selected somatic diagnoses were retrospectively retrieved from national Swedish registries for children born before 24 weeks from 2007 to 2018. Their individual medical files were also examined.RESULTS: We studied 383 children born

The fourth edition of the Diagnostic and Statistical Manual introduced the diagnosis of Acute Stress Disorder (ASD) for acute pathological reactions including dissociative ones, following a traumatic event. Various measures of ASD have been developed, with the Stanford Acute Stress Reaction Questionnaire (SASRQ) being one of the most commonly used across the world. This paper systematically covers

Purpose: One of the main limitations of absorption‐based x‐ray imaging of biomedical specimen is the weak soft‐tissue contrast. This limitation can be addressed by phase‐sensitive imaging methods facilitating considerably improved density resolution. During the last decades various approaches have been investigated ‐ amongst them grating‐based interferometric methods with laboratory x‐ray sources.

INTRODUCTION: A reliable electrocardiographic predictor of ventricular fibrillation (VF) in patients with ST elevation myocardial infarction (STEMI) is lacking so far. Previous experimental/simulation study suggested a terminal T-wave inversion (TTWI) in ischemia-related ECG leads corresponding to anterior infarct localization as an independent predictor of reperfusion VF (rVF). This T-wave charac

Extractive industries often promise prosperity to less economically developed regions of the world. However, projects that rely on extractive industries such as mining often pose significant environmental threats to the host regions. The tension between economic promises and environmental impacts can spark significant conflict in rural communities. This study analyzes a proposed mining project in

The last few decades have witnessed a fundamental change in the administrative law structures of many states. Through the phenomena labelled globalisation, internationalisation and Europeanisation, the national public bodies have seen partially new legal frameworks for administrative activities, judicial review of decisions and accountability regimes. This is very clear in regard to administrative

Introduction: Despite the publication of clinical practice guidelines, the quality of the care process as experienced by patients with osteoarthritis (OA) appears suboptimal. Hence, this study investigates how patients with OA experience their disease and care process, highlighting potential elements that can enhance or spoil it, to optimise their quality of care. Methods: A qualitative study base

This paper presents a differential eight-path bandpass filter with tunable center frequency and bandwidth. Fully differential Miller compensated Butterworth Gm-C biquads are used to implement the active low-pass filters required in the structure of the eight-path filter. The -3-dB bandwidth of each Gm-C filter can be tuned from 2.5 to 51 MHz by means of six digital bits. The center frequency of th

Eight frequently used slope algorithms based on a DEM (Digital Elevation Model) have been compared in flat, gently sloping/undulating, and steep terrain in order to investigate differences in estimated results. The matter of scale/resolution has not been considered, and the focus has not been on comparing the estimates with "ground truth" data but on comparisons between the different algorithms. P

The use of Geographical Information Systems (GIS) within the society as well as in academic work has increased rapidly over the last decades. This also means that Geomatics has started to create problems in both academic and non-academic worlds. Firstly because it bridges borders that have been in place for a long time and secondly because Geomatics, or rather the basic concepts of Geomatics, is i

This study aims to evaluate the accuracy of location (x, y and z) using a Magellan GPS NAV 1000 receiver. The position of a known reference point was compared with 50 fix points measured in two-dimensional (2D) mode (x, y) and with 50 fix points measured in three-dimensional (3D) mode (x, y and z). The mean errors and the root mean square errors (RMSE) in the Euclidian distances between the refere

Backgroundamong the 1–1.5 billion persons with hypertension globally only, 20–30% have controlled blood pressure (BP). The most important problem identified is non-adherence to treatment, i.e., failure to change lifestyle and to take prescribed medication. Knowledge about the reasons for this is limited.ObjectivesThe aim of the study was to explore people's experiences of having hypertension.Desig