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Caspase inhibitors increase short-term survival of progenitor-cell progeny in the adult rat dentate gyrus following status epilepticus

The dentate gyrus (DG) is one of the few regions in the brain that continues to produce new neurons throughout adulthood. Seizures not only increase neurogenesis, but also lead to death of DG neurons. We investigated the relationship between cell death and neurogenesis following seizures in the DG of adult rats by blocking caspases, which are key components of apoptotic cell death. Multiple intrac

Extracellular matrix in disc degeneration.

The extracellular matrix of the intervertebral disc structures contains many molecules also found in cartilage. The extremely polyanionic proteoglycans play a central role, particularly in the nucleus, by creating an osmotic environment leading to retention of water and ensuing resistance to deformation—important for the resilience of the tissue. Another major structural entity particularly impor

Microwaves From UMTS/GSM Mobile Phones Induce Long-Lasting Inhibition of 53BP1/gamma-H2AX DNA Repair Foci in Human Lymphocytes

We have recently described frequency-dependent effects of mobile phone microwaves (MWs) of global system for mobile communication (GSM) on human lymphocytes from persons reporting hypersensitivity to electromagnetic fields and healthy persons. Contrary to GSM, universal global telecommunications system (UMTS) mobile phones emit wide-band MW signals. Hypothetically, UMTS MWs may result in higher bi

Function and Morphology of the Antennal Lobe: New Developments

The antennal lobe of insects has emerged as an excellent model for olfactory processing in the CNS. In the present review we compile data from areas where substantial progress has been made during recent years: structure-function relationships within the glomerular array, integration and blend specificity, time coding and the effects of neuroactive substances and hormones on antennal lobe processi

Developing HMI components for a driver assistance system for safe speed and safe distance

This paper describes a pre-screening procedure that was carried out with a number of candidate Human-Machine-Interaction solutions in three different modes (visual, auditory and haptic) for the concepts of “safe speed and safe distance” (referred to as SASPENCE) of an Advanced Driver Assistance System (termed as ADAS). This procedure was performed simultaneously in two European countries, Sweden a

Sequential and structural homology between intracellular pathogenesis-related proteins and a group of latex proteins

The intracellular pathogenesis-related proteins have been identified in a broad range of flowering plants. Some display quite different patterns of expression, in many cases unrelated to the pathogenic response. Nevertheless, these proteins are all very similar and in most cases share more than 35% sequence identity. In this report we investigate the significance of a rather weak similarity betwee

Ion-pair hollow-fiber liquid-phase microextraction of the quaternary ammonium surfactant dicocodimethylammonium chloride

A two-phase hollow-fiber (HF) liquid-phase microextraction (LPME) method was developed for determination of a quaternary ammonium compound surfactant, dicocodimethylammonium chloride, in aqueous samples. The porous HF was fixed on a metal rod support and was impregnated with approximately 6.6 mu L of organic extractant, which was immobilized in the HF pores. Surfactant extraction was facilitated b

Intraperitoneal 5-fluorouracil in the management of colorectal liver cancer

Twenty-five patients with colorectal liver metastases had a subcutaneous portal connection with a peritoneal catheter implanted for the intraperitoneal (i.p.) administration of 5-fluorouracil (5-FU). In five patients, the malignant disease rapidly progressed and the implanted catheter system was never used. Among the remaining 20 patients, seven patients had i.p. 5-FU as adjuvant treatment followi

Excited state properties of the chromophore of the asFP595 chromoprotein: 2D and 3D theoretical analyses

The ground and excited state properties (e.g., the intramolecular charge and energy transfer, and electron-hole coherence) of the chromophore of the asFP595 chromoprotein from Anemonia sulcata in the neutral and anionic forms are theoretically studied with quantum chemistry methods. The ground-state properties of the asFP595 in the neutral and anionic forms, such as the alternations of the bond le

A reevaluation of the validity of unrestrained plethysmography in mice

Presently, unrestrained plethysmography is widely used to assess bronchial responsiveness in mice. An empirical quantity known as enhanced pause is derived from the plethysmographic box pressure [P-b( t), where t is time] and assumed to be an index of bronchoconstriction. We show that P-b(t) is determined largely by gas conditioning when normal mice breathe spontaneously inside a closed chamber in

Ankle fractures

The results of three separate studies on ankle fractures are presented. Clinical information is provided concerning the epidemiology and a comparison of closed versus open treatment, and a discussion is presented concerning what results can be expected 30 years after closed treatment for an ankle fracture.

-och den ljusnande framtid är vår- : några ungdomars bild av sin tid vid riksgymnasium

Popular Abstract in Swedish Den tid vi i dagens samhälle betraktar som ungdomstid blir allt längre. De ungdomar som lämnar grundskolan tillhör en åldersgrupp som är större än på länge och det stora flertalet av dem är på väg in i svensk treårig gymnasieutbildning. En övergripande specialpedagogisk idé handlar om att alla människor bereds möjlighet att ta del i ett samhälle. Samtidigt finns inte nåThis longitudinal study draws the attention to some adolescents' images of the living-, study- and learning situations into, through and out of the upper secondary school period. The aim implies an examination of the ways a study group with "severe physical disabilities" describes their experiences of phenomena in connection with processes of co-operation and influence. References with particular

The potential for soil carbon sequestration in three tropical dryland farming systems of Africa and Latin America: A modelling approach

Historically, agriculturally induced CO2 release from soils has contributed to rising levels in the atmosphere. However, by using appropriate management, soils can be turned into carbon sinks. Many of the dryland regions of the world are characterised by degraded soils, a high incidence of poverty and a low capacity to invest in agriculture. Two well-proven soil organic matter models (CENTURY 4.0

Fluorescence lifetimes of formaldehyde (H2CO) in the (A)over-tilde(1)A(2) -> (X)over-tilde(1)A(1) band system at elevated temperatures and pressures

Fluorescence lifetimes of formaldehyde excited by picosecond laser radiation with a wavelength of 355 nm were determined in nitrogen gas in a cell using time-resolved laser-induced fluorescence spectroscopy. The measurements were conducted at temperatures between 295 and 770 K and pressures up to 10 bar (1 MPa). Detection was broadband in most cases. Temperature and pressure were found to have a q