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The use of temozolomide (TMZ) for the management of aggressive pituitary tumours (APT) has revolutionised clinical practice in this field with significantly improved clinical outcomes and long-term survival. Its use is now well established however a large number of patients do not respond to treatment and recurrence after cessation of TMZ is common. A number of challenges remain for clinicians suc

Willow (Salix spp.) trees are commonly used in short rotation coppices (SRC) to produce renewable energy. However, these plants are also known to emit high concentrations of biogenic volatile organic compounds (BVOCs), which have a large influence on air quality. Many different clones of commercially used Salix varieties exist today, but only a few studies have focused on BVOC emissions from these

The concept of a holistic innovation policy is defined in this article, with discussions of what it is, why it is relevant, and how it can be implemented to enhance product innovation. It is shown that the innovation systems approach has diffused rapidly during the latest decades and has completely replaced the linear view in the field of innovation research. The majority of European countries are

Who produces scientific and technical knowledge these days? What type of knowledge is being produced and for what purposes? Why are firms and governments funding research and development? This chapter studies the role of knowledge production (especially R&D activities) in the innovation process from an innovation system perspective. It examines how governments and public agencies in different

The main question that guides this paper is how governments are focusing (and must focus) on competence building (education and training) when designing and implementing innovation policies. With this approach, the paper aims at filling the gap between the existing literature on competences on the one hand, and the real world of innovation policy-making on the other, typically not speaking to each

The purpose of this article is to discuss the different types of instruments of innovation policy, to examine how governments and public agencies in different countries and different times have used these instruments differently, to explore the political nature of instrument choice and design (and associated issues), and to elaborate a set of criteria for the selection and design of the instrument

In 2006 the European Commission introduced the concept of "Pre-Commercial Procurement" as an instrument to promote innovation and to mitigate grand challenges. One of the main motivations for the support of Pre-Commercial Procurement schemes was to use public needs as a driver for innovation. This concept was also introduced as a response to the need to reinforce the innovation capabilities of the

This conceptual paper addresses the issues of transparency as linked to artificial intelligence (AI) from socio-legal and computer scientific perspectives. Firstly, we discuss the conceptual distinction between transparency in AI and algorithmic transparency, and argue for the wider concept ‘in AI’, as a partly contested albeit useful notion in relation to transparency. Secondly, we show that tran

In August 1986 some parks in central Malmo were photographed from a height of 760 meters with colour infrared film. Two simultaneous studies were performed to evaluate the feasibility of manual and digital classification of trees with different degrees of crown damage. This damage is mostly due to exhaustion fumes from heavily trafficked roads, mechanical damage to roots and de-icing salt. This pa

The continuous operation of the NOAA series of meteorological satellites from the early 1980s onward, and the use of time series of data from its AVHRR sensor have been instrumental in the development of a new paradigm in the area of global earth observation. The coarse spatial and high temporal resolution of the data contrasts sharply with the data characteristics of traditional earth resource sa