Matrix metalloproteinase-9 (MMP-9) regulates platelet shedding of CD40L in abdominal sepsis. However, the signaling mechanisms controlling sepsis-induced shedding of CD40L from activated platelets remain elusive. Rac1 has been reported to regulate diverse functions in platelets; we hypothesized herein that Rac1 might regulate platelet shedding of CD40L in sepsis. The specific Rac1 inhibitor NSC237

We investigated atmospheric aerosol particle dynamics in a boreal forest zone in northern Scandinavia. We used aerosol number size distribution data measured with either a differential mobility particle sizer (DMPS) or scanning mobility particle sizer (SMPS) at three stations (Varrio, Pallas and Abisko), and combined these data with the HYSPLIT (Hybrid Single Particle Lagrangian Integrated Traject

Immune system is highly integrated with the nervous and endocrine systems, which is thought to result in covariation between behavioural syndromes and stress- and immune-associated diseases. Very little is known about the associations between behaviour and immune traits in wild animals. Here we describe such an association in passerine birds, the greenfinches (Carduelis chloris). When wild-caught

This article introduces a new methodology for deriving the dynamics of visual segmentation in relation to the underlying cognitive processes involved. The method combines social semiotics approaches to visual segmentation with eye-tracking studies on authentic image viewing and simultaneous image description. The authors' thesis is that visual segmentation suggested by the social semiotic approach

Given that tyrosine kinase inhibitors (TKIs) have dramatically improved the survival of patients with chronic myeloid leukaemia (CML), we were interested in examining the possible risk of long-term adverse events, such as the emergence of other neoplasms. Therefore, we studied the development of second malignancies in 868 patients diagnosed with CML between 2002 and 2011 using the Swedish CML regi

By reducing the cadmium (Cd(2+)) content in biomass used for bio-based products such as biogas, a less toxic bio-based fertilizer can be obtained. In this work, we demonstrate how a macroporous polymer can support titanate nanotubes, and we take advantage of its known selective adsorption behavior towards Cd(2+) in an adsorption process from real nutrient-rich process water from hydrolysis of seaw

We obtain new results on Fourier multipliers for Dirichlet-Hardy spaces. As a consequence, we establish a Littlewood-Paley inequality, and we give a simple proof that the Dirichlet monomials form a Schauder basis for p>1.

The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Variou

Acrylamide is a chemical compound present in tobacco smoke and food, classified as a probable human carcinogen and a known human neurotoxin. Acrylamide is formed in foods, typically carbohydrate-rich and protein-poor plant foods, during high-temperature cooking or other thermal processing. The objectives of this study were to compare dietary estimates of acrylamide from questionnaires (DQ) and 24-

Agonistic anti-CD40 monoclonal antibodies (mAbs) hold great potential for cancer immunotherapy. However, systemic administration of anti-CD40 mAbs can be associated with severe side effects, such as cytokine release syndrome and liver damage. With the aim to increase the immunostimulatory potency as well as to achieve a local drug retention of anti-CD40 mAbs, we linked an agonistic mAb to immune a

Neutron-rich ^{96,98}Sr isotopes have been investigated by safe Coulomb excitation of radioactive beams at the REX-ISOLDE facility. Reduced transition probabilities and spectroscopic quadrupole moments have been extracted from the differential Coulomb excitation cross sections. These results allow, for the first time, the drawing of definite conclusions about the shape coexistence of highly deform

Pronounced growth restriction occurs after very preterm birth. The interaction between IGF-I, nutritional intake and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) weeks. Blood sampling of IGF-I and measurements of weight, length and head circumference were performed weekly until discharge. Daily calculation of nutritional intake. Standard deviation scores (SDS)

The full Holocene development of the large (8100 km(2)) Vatnajokull ice cap in Iceland with its many outlet glaciers is poorly known. The idea of an early deglaciation, leading to a glacier-free period in mid-Holocene, followed by the Neoglaciation is still the main concept for the glacial history in the North Atlantic region, including Iceland. We have examined a continuous sediment record from t

The natural moisturizing factor (NMF) is a group of hygroscopic molecules that is naturally present in skin and protects from severe drying. Glycerol and urea are two examples of NMF components that are also used in skin care applications. In the present study, we investigate the influence of glycerol and urea on the permeability of a model drug (metronidazole, Mz) across excised pig skin membrane

The paper presents numerical results for a two-scale damage model accounting for mixed-mode propagation of micro-cracks. A time-dependent propagation criterion is assumed for microcrack growth and a kinking direction criterion based on the maximum of the energy-release rate is used. The macroscopic damage evolution laws are obtained by homogenization based on asymptotic developments. A numerical p

Sediment cores from the Kriegers Flak area in the southwestern Baltic Sea show a distinct lithological succession, starting with a lower diamict that is overlain by a c. 10 m thick clay unit that contains peat, gyttja and other organic remains. On top follows an upper diamict that is inter-layered with sorted sediments and overlain by an upward-coarsening sequence with molluscs. In this paper we f

Solar energy conversion into electricity by photovoltaic modules is now a mature technology. We discuss the need for materials and device developments using conventional silicon and other materials, pointing to the need to use scalable materials and to reduce the energy payback time. Storage of solar energy can be achieved using the energy of light to produce a fuel. We discuss how this can be ach