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The development of real-time PCR thermal cycles in the late 1990s has opened up the possibility of accurate quantification of microorganisms in clinical, environmental, and food samples. However, a lack of suitable sample preparation methods that allow rapid quantification of the nucleic acids, remove PCR inhibitors, and prevent false-positive results due to DNA originating from dead cells has lim

The influence of the shear on the lamellar phase, L, of the system C10E3/D2O was studied along an isoplethal path (40 wt.% C10E3) in the temperature range 25-42degreesC. A dynamic phase diagram was determined by steady-state rheometry, where by shear action the lamellar phase was transformed into multilamellar vesicles (MLVs) ("onions"). The location of "onions" in the dynamic phase diagram, depen

We present a model that explains the anomalous intensity ratios betweeneach of two very bright UV lines of Fe II at 2507 Å and 2509Å and its corresponding satellite line, observed in HST spectra ofa compact gaseous condensation (blob B) in the vicinity of the starprotect eta Car.The model is based on the assumption that the FeIItransitions have a substantial optical thickness, which varies as ares

In this paper an extension of the q-deformed Volterra equation associated with linear rescaling to the general non-linear rescaling is obtained.

Although long-acting inhaled beta(2)-agonists improve various outcome measures in COPD, no double-blind study has yet shown a significant effect of these drugs on exercise capacity. In a randomized, double-blind, placebo-controlled, crossover study, patients received formoterol (4.5,9, or 18 mug b.i.d via Turbuhaler(R)), ipratroplum bromide (80 mug t.i.d via pMDI with spacer), or placebo for I wee

The subject of this thesis is the pushforward map on compactly supported distributions induced by a smooth mapping. Being the adjoint of the natural pullback operation on the class of smooth functions, the pushforward map is always well-defined, and as such it must be regarded as one of the fundamental operations of distribution theory. This thesis has two main aims: The first of these is to give

Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit alpha of PI3K (PIK3CA) occurs frequently in human cancer. We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV. To investigate the relationship between PTEN and PIK3CA, we generated a coh

This paper is the third in a series which recounts experiences in a project conducted in a newly created department of the University of Portsmouth, following a faculty reorganization. In this context, the 25 staff of the department wished to explore possibilities ofr development in a range of areas of work. A variant of the framework for Strategic Systemic Thinking (SST) was used to support such

This paper offers a method for quantifying the global exchange of (natural) space and (labor) time underlying the economic success of the British textile industry in the late 18th and early 19th century. Using historical statistics on inputs of land and labor embodied in cotton and wool production, respectively, estimates are made of the amount of British land and labor that were ‘saved’ by displa

The amount of software around us has increased incredibly. A lot of the new software is integrated into different devices, for example, home electronics, cars and cell-phones. As existing and new systems evolve through different maintenance releases, they naturally inherit functionality and characteristics from previous releases and therefore become what we refer to as legacy systems. Often new fu

We investigated the effects of UDCA on sphingomyelinase (SMase) in Caco 2 cells cultured in monolayer and polarized conditions. Alkaline SMase activity was high in polarized cells whereas. acid and neutral SMase activities were high in monolayer cells. In polarized cells, UDCA increased alkaline SMase expression and caspase 3 activity but had no effect on acid and neutral SMases. In monolayer cell