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Decay of 48-50Ar isotopes

Information on β-decay properties of neutron-rich 48-50Ar was obtained at the ISOLDE mass-separator facility at CERN using isobaric selectivity. This was achieved by a combination of a plasma-ion source with a cooled transfer line and subsequent mass-separation. Normally, argon beams cannot be mass-separated from intense multi-charged symmetric fission krypton and xenon. Several techniques were us

A multi-proxy approach to drought reconstruction

In palaeoclimate reconstructions, the combination of proxy records measured in different climate archives is challenging because of the uncertainties associated with each proxy, but it can also help reduce some of these uncertainties. Here, we present a novel approach to combine speleothem and tree ring proxies for a drought reconstruction of the last 640 years: a fluid inclusion δ18O record from

Evidence for a smooth onset of deformation in the neutron-rich Kr isotopes

The neutron-rich nuclei Kr94,96 were studied via projectile Coulomb excitation at the REX-ISOLDE facility at CERN. Level energies of the first excited 2 + states and their absolute E2 transition strengths to the ground state are determined and discussed in the context of the E(21+) and B(E2;21+→01+) systematics of the krypton chain. Contrary to previously published results no sudden onset of defor

The 8Li + 2H reaction studied in inverse kinematics at 3.15 MeV/nucleon using the REX-ISOLDE post-accelerator

The reaction 8Li + 2H has been studied in inverse kinematics at the incident energy of 3.15 MeV/nucleon, using the REX-ISOLDE post-accelerator. The reaction channels corresponding to (d,p), (d,d), and (d,t) reactions populating ground states and low-lying excited states in 7 -9Li have been identified and the related angular distributions extracted and compared with coupled-channels, distorted-wave

Transfer reactions on neutron-rich nuclei at REX-ISOLDE

We report on one- and two-neutron transfer reactions to study the single-particle properties of nuclei at the border of the "island of inversion". The (d,p)- and (t,p)-reactions in inverse kinematics on the neutron-rich isotope 30Mg, delivered as radioactive beam by the REX-ISOLDE facility, have been investigated. The outgoing protons have been detected and identified by a newly built array of Si

Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer

Background: Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment of a minor subgroup of non-small cell lung cancer (NSCLC) patients. Although fluorescence in situ hybridization (FISH) is regarded as the gold standard for detection of ALK rearrangements, ALK immunohistochemistry (IHC) is often used as screening tool in clinical practice. In order to unbiasedly anal

Assessing optimal blood pressure in patients with asymptomatic aortic valve stenosis

Background: Evidence for treating hypertension in patients with asymptomatic aortic valve stenosis is scarce. We used data from the SEAS trial (Simvastatin Ezetimibe in Aortic Stenosis) to assess what blood pressure (BP) would be optimal. Methods: A total of 1767 patients with asymptomatic aortic stenosis and no manifest atherosclerotic disease were analyzed. Outcomes were all-cause mortality, car

Extracellular matrix composition defines an ultra-high-risk group of neuroblastoma within the high-risk patient cohort

Background:Although survival for neuroblastoma patients has dramatically improved in recent years, a substantial number of children in the high-risk subgroup still die.Methods:We aimed to define a subgroup of ultra-high-risk patients from within the high-risk cohort. We used advanced morphometric approaches to quantify and characterise blood vessels, reticulin fibre networks, collagen type I bundl

The stem cell niche finds its true north

The third ‘Stem Cell Niche’ meeting, supported by The Novo Nordisk Foundation, was held this year on May 22-26 and brought together 185 selected participants from 24 different countries to Hillerød, Denmark. Diverse aspects of embryonic and adult stem cell biology were discussed, including their respective niches in ageing, disease and regeneration. Many presentations focused on emerging technolog

Impact by pancreatic stellate cells on epithelial-mesenchymal transition and pancreatic cancer cell invasion : Adding a third dimension in vitro

Pancreatic cancer is associated with a highly abundant stroma and low-grade inflammation. In the local tumour microenvironment, elevated glucose levels, the presence of tumour-associated stellate cells and macrophages are hypothesised to promote the tumour progression and invasion. The present study investigated the influence by the microenvironment on pancreatic cancer cell invasion in vitro. Aft

Port-A-Cath usage in children with haemophilia : Experience of 53 cases

Experience of the Port-A-Cath implantable venous access system in 53 children with severe or moderate haemophilia A or B from seven centres in five countries is reviewed. The cumulative duration of follow-up was 1578 months (median 30 months, range 1-114). Of the devices implanted, 70% (37/53) were used without complications (median follow-up 32 months; range 1-114) and the remaining 30% (16/53) w

High prevalence of thyroid autoantibodies at diagnosis of insulin-dependent diabetes mellitus in Swedish children

The prevalence of thyroglobulin autoantibodies and that of thyroid peroxidase autoantibodies were studied in serum samples from 52 children with insulin-dependent diabetes mellitus, sampled at diagnosis and before the start of insulin treatment, with 386 non-diabetic schoolchildren (11 to 13 years of age) serving as control subjects. Using exactly the same sensitive solid-phase immunosorbent radio

Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise. To catalog the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive pipeline for analyzing RNA sequencing data, which we integrated with whole genomes from 23 breast cance

Same place, same knowledge – Same people? The geography of non-patent citations in Dutch polymer patents

It has long been argued that geographic co-location supports knowledge spillovers. More recently, this argument has been challenged by showing that knowledge spillovers mainly flow through social networks, which may or may not be localized at various geographic scales. We further scrutinize the conjecture of geographically bounded knowledge spillovers by focusing on knowledge flows between academi

Acceptance, Attrition, and Outcome in an Outpatient Treatment Programme for Alcoholics : a Comparison Between a Randomized and a Non-Randomized Process-Outcome Study

Acceptance, attrition and outcome of the same outpatient treatment programme for alcoholics was studied first in a non-randomized and later in a randomized study. There was a lower (15%) rate of acceptance and a higher (19%) rate of attrition in the randomized study. Among treatment completers drinking outcome during the third year after commencement of treatment did not differ between the non-ran