Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. The anthracyclines are efficient chemotherapeutic agents against cancer, but their use is limited due to cardiotoxicity and induction of multidrug resistance. In the search for new anthracycline analogs, a daunosamine

This chapter presents a telehealth system called GiraffPlus supporting independent living of elderly in their own home. GiraffPlus system is a complex system which monitors activities and physiological parameters in the home using a network of sensors. The elaborated information is presented to the primary user, the elderly, and to secondary users like health care and home care providers and possi

Popular Abstract in Swedish Ger en ökad fysisk aktivitet bland växande barn bättre skelett- och muskelutveckling och påverkar det i så fall frakturrisken? Benskörhet och låg benmassa medför en ökad risk för frakturer. Låg fysisk aktivitet är också en riskfaktor. En ökad frakturförekomst är i dag ett växande samhällsproblem, och med dessutom en åldrande population samt en generellt mindre fysiskt Osteoporosis and related fractures are a global health problem. Physical activity, especially during growth, has been suggested as a strategy to improve musculoskeletal health in the population. Previous prospective pediatric exercise intervention studies, however, are short-term, mostly covering less than one year and use bone traits as surrogate endpoints for fractures. The Pediatric Osteoporosi

Targino, A. C., Krecl, P., Johansson, C., Swietlicki, E., Massling, A., Coraiola, G. C. & Lihavainen, H. 2013: Deterioration of air quality across Sweden due to transboundary agricultural burning emissions. Boreal Env. Res. 18: 19-36. We analyzed measurements of aerosol and trace-gas concentrations from sites across Sweden before and during a series of agricultural wildland fires in eastern Eu

Aim: To compare treatment costs with alternative luteinizing hormone-releasing hormone (LHRH) agonist preparations and determine whether a leuprorelin solid implant is associated with potential cost savings. Patients & methods: A hypothetical population of 1000 prostate cancer patients was apportioned between the three most commonly-prescribed LHRH agonist preparations. Differentiated annual c

In this paper, we construct protograph-based spatially coupled low-density parity-check (LDPC) codes by coupling together a series of L disjoint, or uncoupled, LDPC code Tanner graphs into a single coupled chain. By varying L, we obtain a flexible family of code ensembles with varying rates and frame lengths that can share the same encoding and decoding architecture for arbitrary L. We demonstrate

The energy level structure and dynamics of biomolecules are important for understanding their photoinduced function. In particular, the role of carotenoids in light-harvesting is heavily studied, yet not fully understood. The conventional approach to investigate these processes involves analysis of the third-order optical polarization in one spectral dimension. Here, we record two-dimensional corr

ABSTRACT: BACKGROUND: Evaluation of an implementation process and its fidelity can give insight into the 'black box' of interventions. However, a lack of standardized methods for studying fidelity and implementation process have been reported, which might be one reason for the fact that few prior studies in the field of health service research have systematically evaluated interventions' implement

The semantic content, or the meaning, is the essence of autobiographical memories. In comparison to previous research, which has mainly focused on the phenomenological experience and the age distribution of retrieved events, the present study provides a novel view on the retrieval of event information by quantifying the information as semantic representations. The aim of the study was to investiga

In the search for the fully aligned 27(-) state in Nd-140 predicted by cranked Nilsson-Strutinsky calculations, new close-to-spherical high-spin states have been discovered. Both the close-to-spherical and the triaxial calculated states are in good agreement with the experimental results, supporting the existence of shape coexistence up to very high spins. Shell-model calculations using a newly de

Global concerns about climate changes and their association with the use of fossil fuels have accelerated research on biological fuel production. Biological hydrogen production from hemicellulose-containing waste is considered one of the promising avenues. A major economical issue for such a process, however, is the low substrate conversion efficiency. Interestingly, the extreme thermophilic bacte

Background: Many patients with aggressive B-cell lymphomas and high clinical risk score still die of lymphoma after conventional R-CHOP chemoimmunotherapy. We hypothesized that intensified chemoimmunotherapy including systemic central nervous system (CNS) prophylaxis improves outcome and reduces the incidence of CNS-related events. Patients and methods: Inclusion criteria were age 18-65 years, pri

The administration of hydroxocobalamin (OHCob), alone or with sodium thiosulfate, is a standard therapy for cyanide poisoning. OHCob is a red chromophore, and its interference with co-oximetric and colorimetric laboratory measurements has been evaluated in a few conflicting reports. The interference of OHCob was investigated in samples spiked with 10 different concentrations of OHCob (0-1500 mg/L)

Background Previous Studies have shown increased familial risk for chronic lymphocytic leukemia. In the most comprehensive study to date, we evaluated risk of chronic lymphocytic leukemia and lymphoproliferative disorders among First-degree relatives of chronic lymphocytic leukemia cases compared to first-degree relatives of controls. Design and Methods Population-based registry data from Sweden w

Popular Abstract in Swedish I Sverige finns cirka 350 000 personer med diabetes. Motsvarande siffra i hela världen är cirka 350 miljoner människor och forskning talar för att antalet personer med diabetes kommer att öka dramatiskt under de närmsta decennierna. Den största ökningen sker i utvecklingsländer i urbana områden, till stor del beroende på livsstilsförändringar och förändringar i diet. UtSpecific aims: To examine whether the sociodemographic characteristics of patients with type 2 diabetes affect the odds of reaching the recommended treatment goals for HbA1c and blood lipids (study 1). To investigate whether the odds of coronary heart disease are higher in patients with diabetes living in deprived neighborhoods than in those living in wealthy neighborhoods (Study 2). To examine th

Cluster headache is a primary headache by definition not caused by any known underlying structural pathology. Symptomatic cases have been described, for example tumours, dissections and infections, but a causal relationship between the underlying lesion and the headache is difficult to determine in many cases. The proper diagnostic evaluation of cluster headache is an issue unresolved. The literat