Nonsense-mediated mRNA decay (NMD) is a post-transcriptional surveillance process that eliminates mRNAs containing premature termination codons (PTCs). NMD has been hypothesized to impact on several aspects of cellular function; however, its importance in the context of a mammalian organism has not been addressed in detail. Here we use mouse genetics to demonstrate that hematopoietic-specific dele

This paper assesses the potential effects from trade facilitation in terms of increased trade flows both on average and specifically for the six regional groups of ACP countries negotiating Economic Partnership Agreements (EPAs) with the EU. Data from the World Bank’s Doing Business Database on the time required to export or import are used as indicators of cross-border transaction costs, and a gr

Due to its four decades of high long-term economic growth and democratic system, Botswana has been depicted as an exceptional success story in a region full of economic and political failures. In this article,,a structural analysis is applied, and it is argued that Botswana's success should be understood as one of pre-modern growth without development. It is claimed that although the country may b

Background: Zinc deficiency is a significant problem, in developing countries and in vegetarians, which can be caused by plant-based diets. Thus, dietary strategies, such as fermentation, to improve zinc bioavailability of diets should be investigated. Objective: To improve zinc bioavailability in a plant-based diet by the inclusion of fermented food. Design: Cassava tubers were fermented and made

A multi-cell He gas scintillator active target, designed for the measurement of photoreaction cross sections, is described. The target has four main chambers, giving an overall thickness of 0.103 g/cm(3) at an operating pressure of 2MPa. Scintillations are read out by photomultiplier tubes and the addition of small amounts of N-2 to the He, to shift the scintillation emission from UV to visible, i

Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure. There are two subtypes: typical HUS associated with enterohemorrhagic E. coli (EHEC) and atypical HUS associated with uninhibited activation of the alternative pathway of complement. EHEC produce virulence factors such as lipopolysaccharide (LPS) and

The Swedish Association for Applied Linguistics, ASLA (Association suédoise de linguistique appliquée) was formally founded as an autonomous Swedish affiliate of AILA in 1966. The constituting meeting was held at Lund University on April 12, 1966 during which the first chairperson, Professor Bertil Malmberg, was elected. This means that ASLA will be celebrating its 50th anniversary in 2016. Howeve

High-pressure X-ray photoelectron spectroscopy, mass spectrometry, and density functional theory calculations have been combined to study methane oxidation over Pd(100). The measurements reveal a high activity when a two-layer PdO(101) oriented film is formed. Although a one-layer PdO(101) film exhibits a similar surface structure, no or very little activity is observed. The calculations show that

Context: The risk of many conditions, including prostate cancer, breast cancer, and osteoporosis, is associated with serum levels of sex steroids. Objective: The aim of the study was to identify genetic variations in sex steroid-related genes that are associated with serum levels of estradiol (E2) and/or testosterone in men. Design: Genotyping of 604 single nucleotide polymorphisms in 50 sex stero

This article examines how knowledge of an impending collapse of modern industrial civilization circulated in Swedish society during the early 1970s. The point of departure is the Swedish biochemist Gösta Ehrensvärd’s (1910–1980) short book Före – efter: En diagnos (Before – After: A Diagnosis). In this book Ehrensvärd argued that the technologically advanced societies of the early 1970s would soon

Nanostructures have many material, electronic, and optical properties that are not found in bulk systems and that are relevant for technological applications. For example, nanowires realized from III-V semiconductors can be grown into wurtzite crystal structure. This crystal structure does not naturally exist in bulk where these materials form the zinc-blende counterpart. Being able to concomitant

Energy relay dyes (ERDs) have been investigated previously as a mean to achieve panchromatic spectral response in dye-sensitized solar cells via energy transfer. To reduced the distance between the ERDs and energy-accepting injection dyes (IDs) on the surface of a mesoporous titanium dioxide electrode, the ERDs were immobilized adjacent to the IDs via a sequential functionalization approach. In th

Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. The anthracyclines are efficient chemotherapeutic agents against cancer, but their use is limited due to cardiotoxicity and induction of multidrug resistance. In the search for new anthracycline analogs, a daunosamine

This chapter presents a telehealth system called GiraffPlus supporting independent living of elderly in their own home. GiraffPlus system is a complex system which monitors activities and physiological parameters in the home using a network of sensors. The elaborated information is presented to the primary user, the elderly, and to secondary users like health care and home care providers and possi

Popular Abstract in Swedish Ger en ökad fysisk aktivitet bland växande barn bättre skelett- och muskelutveckling och påverkar det i så fall frakturrisken? Benskörhet och låg benmassa medför en ökad risk för frakturer. Låg fysisk aktivitet är också en riskfaktor. En ökad frakturförekomst är i dag ett växande samhällsproblem, och med dessutom en åldrande population samt en generellt mindre fysiskt Osteoporosis and related fractures are a global health problem. Physical activity, especially during growth, has been suggested as a strategy to improve musculoskeletal health in the population. Previous prospective pediatric exercise intervention studies, however, are short-term, mostly covering less than one year and use bone traits as surrogate endpoints for fractures. The Pediatric Osteoporosi