Background/objectives: Alzheimer’s disease (AD) is currently diagnosed clinically using defined symptomatic diagnostic criteria. Pathological levels of CSF-biomarkers, high T-tau, P-tau and low Ab42 have been associated with AD however definition of cut off values differ. New diagnostic criteria that include the pathological CSF biomarkers have been suggested. How many AD patients in a routine cli

Abstract in German Die Lektüre von Still Songs eröffnet einen neuen, interessanten und zugleich kritischen Blick auf Celans „MusikGedichte“ und deren Vertonungen und auf die Celan-Forschung überhaupt. Passagen zur Detailebene einzelner Gedichte – wie Todesfuge, Schlaflied, Saitenspiel, Engführung oder Fadensonnen – und deren Vertonungen – durch Tilo Medek, Erhard Karkoschka, Harrison Birtwistle, A

Managing the resources of a virtualized data-center is a key issue in cloud computing. Existing research mostly assumes that applications are either allocated the required resources or fail. Combined with the fact that most cloud applications have dynamic resource requirements, this imposes a fundamental limitation to cloud computing: To guarantee on-demand resource allocations, the data-center ne

In this paper, trade policy formation is incorporated into an economic geography model. The political setup used is a modified version of that introduced by Grossman and Helpman (1994) in which policy makers may be in‡uenced by lobbying contributions. On the basis of the underlying trade framework, lobbying activity is performed in benefit of capital interests. Optimal policy outcomes indicate tha

The breakdown of traditional marine tenure systems and overexploitation of marine organisms as a result of rapid modernization, urbanization and population growth in the case of Tonga is outlined. The customary marine tenure system is described and the threats against the coral reefs are discussed. It is shown how accumulative strategies correlate with the move toward overexploitation. It is argue

The basic Helix-Loop-Helix (bHLH) proteins are a family of transcription factors that are found in almost all eukaryotic genomes. This family of proteins regulates a variety of biological processes including embryonic development. Here we describe the catalog of human, mouse and rat bHLH proteins. Extensive in silico studies identified 121 human, 121 mouse and 120 rat bHLH proteins. Human has orth

A conceptual model for the relationships between wellbeing and health in old age were construed. In the model life history evaluations, current sense of coherence (SOC) and social network characteristics defined wellbeing. Health was defined as reported symptoms, subjective health and health care utilization. Firstly, interrelationships between the wellbeing aspects and between the health aspects

Protein biosynthesis is performed on ribosomes. The ribosome is a complex of ribosomal RNA and proteins forming two subunits. A messenger RNA strand is decoded on the small subunit by charged aminoacyl transfer RNA (aa-tRNA) molecules and each tRNA molecule delivers its amino acid to the growing polypeptide chain on the large subunit. RNA performs the central reactions and ribosomal proteins and f

We note that today ideas and models regarding both how to perform activities and how to pre¬sent oneself are generously offered to all organisations. Thus ideas concerning organisational models, management principles and quality assurance travel between countries, fields and organisations (Czarniawska and Sevòn, 1996). Organisations in the public sector, faced with the demand for higher productivi

This paper focuses on the many extreme credit default swap spread movements observed during the credit crisis 2007-08 and on how the tails of the spread change distribution significantly differ from those of the normal distribution. As a result, Value at Risk (VaR) estimates based on extreme value theory are found to be more accurate than those based on normal or historical distributions, particul

The development of the European Higher Education Area (EHEA) is firmly rooted in the idea of higher education (HE) as the cornerstone of a knowledge-based society. Throughout Europe, HE bodies are addressing issues of quality, mobility, employability and lifelong learning. HE agencies and institutions alike are working hard to harmonise European degrees and apply quality assurance standards (ESG,