Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow ace

Amperozide is a novel psychotropic compound with specific effect in limbic brain areas. Preliminary findings have also indicated an antiarrhythmic effect in-vitro. Injections of saline, amperozide, melperone, thioridazine, bretylium or lignocaine, were given i.p. to anaesthetized guinea-pigs, which 10 min later were given digoxin s.c. to induce arrhythmia. In a series of control experiments none o

We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg X kg-1) over 1 h, followed by a maintenance infusion (0.5 mg X kg-1 X h-1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during th

Metabolic interactions between theophylline and several other drugs have been described in a number of studies. They may be of importance because of the narrow therapeutic range of theophylline. A significant risk for interactions has been considered to exist only with drugs metabolized by oxidative enzyme systems, and thus is not expected to occur with isoniazid. However, an increased clearance o

A selective and sensitive reversed-phase high-performance liquid chromatographic method for simultaneous analysis of diltiazem and its five metabolites known to occur in man is presented. Different C18 columns are compared. The influences of organic co-solvent, pH, ionic strength and the addition of various amines are studied. The use of trans-diltiazem as internal standard is advocated. UV detect

From studies on prophylaxis against experimental streptococcal endocarditis using amoxycillin in a single dose, it has been deduced that serum concentrations above 0.12 mg/l should be maintained for at least 10 h after antibiotic administration. Since concentrations above this level are reported to occur following an oral dose of 3 g of amoxycillin, this doses for prophylaxis has become widely acc

This thesis is an inquiry into musical interpretation and performance. It builds on my practice as a professional baroque violinist. Qualitative analysis of the video documentation of my individual practise, rehearsals, and concert performances is the core method of the project. Here, the roles of a musical score, of performance practice, instruments, and the human body in musical creativity are e

OBJECTIVE: Recent studies suggest that administration of O2 in patients with acute myocardial infarction may have negative effects. With the use of cardiac MRI (CMR), we evaluated the effects of supplemental O2 in patients with ST elevation myocardial infarction (STEMI) accepted for acute percutaneous coronary intervention (PCI).MATERIALS AND METHODS: This study was a randomized-controlled trial c

Nowadays, the main two issues of heating ventilation and air conditioning (HVAC) are refrigerant alternative and system efficiency improvement. As a safe and environmental protective refrigerant, CO2 has drawn a lot of attention these years. The improvement on its transcritical cycle efficiency has always been the study hotspot. On the basis of the traditional cycle system, this paper adds the int

Purpose: “Scale purification” – the process of eliminating items from multi-item scales – is widespread in empirical research, but studies that critically examine the implications of this process are scarce. The goals of this research are threefold: to discuss the methodological underpinning of scale purification, to critically analyze the current state of scale purification in supply chain manage

The quantum yield is a critically important parameter in the development of lanthanide-based upconverting nanoparticles (UCNPs) for use as novel contrast agents in biological imaging and optical reporters in assays. The present work focuses on the influence of the beam profile in measuring the quantum yield (φ) of nonscattering dispersions of nonlinear upconverting probes, by establishing a relati

In this paper we analyze the motives, functioning, and results of vocational education and training in two companies in the shipbuilding industry in two different countries (Japan and Sweden) in different time periods. The institutional framework differs substantially in the two cases and, partly as a consequence, the responses to challenges in securing an adequate supply often varied. However, ou

Under 1990-talet kom ordet kulturarv att användas för att beskriva samhällets förmåga, vilja och praktiker för att bevara och använda företeelser ur det förflutna. I Sverige, liksom i Europa, genomfördes under denna tid flera politiskt initierade satsningar och projekt som handlade om både hur kulturarv kunde tjäna samhället och vad som borde ingå i kategorin kulturarv.Boken handlar om dessa proje

Björn Wahlroos storljuger när han hävdar att skattebetalarna räddade Nordbanken, inte Nordea. Men oron över flytten är överdriven. Istället kan den innebära att det osunda starka inflytandet som de största bankerna har över svensk politik är på väg att luckras upp. Det skriver Anders Ögren, docent i ekonomisk historia.

Objective: To investigate the possible disease-association and pathogenic mechanisms of heterozygous PINK1 mutations from a genetic, functional, and structural perspective. Background: It has been postulated that heterozygous mutations in recessive PD genes may increase disease risk. In particular, the PINK1 p.G411S mutation has been reported in families with dominant inheritance patterns, suggest

Corrosion of steel reinforcement is a large and increasing problem for reinforced concrete structures. Simple and reliable assessment methods are required to use the full capacity of existing infrastructure. In this paper, a reliable engineering assessment method is outlined. A model for anchorage has been developed and verified against a large database of bond tests. Also the influence of corrosi