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Increased health care utilization by survivors of childhood lymphoblastic leukemia is confined to those treated with cranial or total body irradiation: a case cohort study.

Previous studies have indicated that survivors of childhood acute lymphoblastic leukemia (ALL) have an increased morbidity measured in terms of health care utilization. However, earlier studies have several potentially important limitations. To overcome some of these, we investigated hospital contact rates, and predictors thereof, among 5-year survivors of ALL in a population-based setting, and co

Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity

Neuropeptide Y (NPY) has been implicated in anxiolytic- and antidepressant-like behaviour as well as seizure-suppressant effects in rodents. Although these effects appear to be predominantly mediated via other NPY receptors (Y1 and/or Y2), several studies have also indicated a role for Y5 receptors. Gene therapy using recombinant viral vectors to induce overexpression of NPY, Y1 or Y2 receptors in

Selection on pollen and pistil traits during pollen competition is affected by both sexual conflict and mixed mating in a self-compatible herb.

Although much attention has focused on the diversity of plant mating systems, only a few studies have considered the joint effects of mating system and sexual conflict in plant evolution. In mixed-mating Collinsia heterophylla, a sexual conflict over timing of stigma receptivity is proposed: pollen with a capacity to induce early onset of stigma receptivity secures paternity for early-arriving pol

Psychotropic drug use in adolescents born with an orofacial cleft: a population-based study.

Being born with an orofacial cleft (OFC) can, due to an incomplete closure of the lip and/or palate, convey a deviant speech and/or deviant facial aesthetics, which may in turn increase the risk for poor psychological health later in life. Previous investigations have been based on small samples and self-reports, not distinguishing between the three different types of OFC: cleft lip (CL), CL and p

Changing Landscapes and Persistent Places : An Exploration of the Bjäre Peninsula

Changing Landscapes and Persistent Places is a study of the cultural landscape on the Bjäre peninsula in northwest Skåne. The many Bronze Age remains that give the landscape its distinctive character are the starting point for an attempt to increase our understanding of the historical depth of today’s landscape. The two perspectives of “landscape” and “places” carry the discussion forward, almost

Cystic Fibrosis - long term results of a treatment package including preventive physical exercise

Popular Abstract in Swedish Cystisk Fibros Cystisk Fibros (CF) är en relativt vanlig ärftlig sjukdom. Ungefär 1/37 personer i Sverige bär på anlag till CF, men bärare har inga symptom och vet därför inte att de har anlagen. För att få sjukdomen måste fostret få två anlag, ett från vardera föräldern, vilket är 25% risk vid varje graviditet för föräldrapar där båda är bärare. CF är en dödlig sjukdomCystic Fibrosis (CF) is a severe hereditary disorder leading to progressive deterioration of lung function and death. This thesis describes the demography of CF in Sweden, its treatment, with special reference to physiotherapy, and its effects on lung function and peak working capacity (PWC). The study is based on Swedish CF patients and evaluates our current CF treatment package, which differs fr

Pegylated interferon alfa and ribavirin for 14 versus 24 weeks in patients with hepatitis C virus genotype 2 or 3 and rapid virological response

A recent nonrandomized pilot trial showed that hepatitis C virus (HCV) patients with genotype 2/3 and rapid virological response (RVR) had a 90% sustained virological response (SVR) rate after 14 weeks of treatment. We aimed to assess this concept in a randomized controlled trial. In the trial, 428 treatment-naive HCV RNA-positive patients with genotype 2 or 3 were enrolled. Patients with RVR were

Analytic Parameterization of Stabilizing Controllers for the Surge Subsystem of the Moore-Greitzer Compressor Model

This paper is based on a new procedure for dynamic output feedback design for systems with nonlinearities satisfying quadratic constraints. The new procedure is motivated by the challenges of output feedback control design for the 3-state Moore-Greitzer compressor model. First, we use conditions for stability of a transformed system and the associated matching conditions to find the data of the st

Dvärgagen återupptäckt i Sverige efter 63 år som utgången.

Cyperus fuscus was thought to be extinct in Sweden until it was rediscovered at Lake Vombsjön, Skåne, after 63 years in 2013. The species also occurred at the lake 2014—2021, but in very variable numbers. The variation depended largely on the water level during late summer. Favourable conditions in form of low levels in late summer have also occurred prior to 2013, though less frequently than in rCyperus fuscus was rediscovered at Lake Vombsjön in Skåne, southernmost Sweden, in 2013. The species occurred there between 1945 and 1950, which was the latest Swedish record except for a casual occurrence in a plant nursery. The comeback was spectacular with 2770 individuals counted along 4.7 km of the shore. In 2013, the water level was exceptionally low for technical reasons, with up to 100 m o

Evacuation models are running out of time

The representation of crowd movement in existing evacuation models is typically based on data collected in the 1950s to 1980s, i.e., data that are more than 40 years old. Since the 1970s, population characteristics have changed dramatically around the world. Reports show that the percentage of elderly and obesity rates have increased significantly and this trend is predicted to continue into the f

Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Felaktig DNA-reparation av typen mismatch repair (MMR) uppkommer i 15-17% av cancer i tjock- och ändtarm (kolorektalcancer). MMR defekter är av betydelse i tre situationer: • MMR defekta tumörer har en bättre prognos än övrig tjock- och ändtarmscancer, vilket kan användas för att avgöra huruvida en patient skall erbjudas sk. adjuvant Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). The identification of MMR defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment-predi

Mirrors in Russian Women’s Autobiographical Writing : The Self Reflected in Works by Alla Demidova and Vera Luknitskaia

In autobiographical writing, the mirror is not only a privileged metaphor for the genre as a whole; it also functions as a primary administrator of boundaries, demarcating the space of the self from the foreign, the chaotic, the unknown. The mirror metaphor is not a gender neutral one: in Western elite culture the mirror has served to reinforce the patriarchal dichotomy between man/mind and woman/

Additions to the lichens and lichenicolous fungi of Denmark 8

Eiglera flavida and Epilichen scabrosus should be deleted from the Danish checklist. The collections of Caloplaca citrina are revised and most of them referred to C. flavocitrina. Amandinea pelidna, Arthonia peltigerae, A. phaeophysciae, Caloplaca britannica, C. polycarpa, Clauzadea metzleri, Cyphelium karelicum, Dendrophoma lecanorae, Didymellopsis collematum, Endococcus protoblasteniae, Ephebe p

Propagating Surface Plasmon Induced Photon Emission from Quantum Dots.

We investigate the interaction between propagating surface plasmons in silver nanowires and excitons generated in quantum dots. We show propagating surface plasmons can excite excitons, which results in quantum dot emission. In this process, the energy is directly transferred from the propagating surface plasmons to the excitons without converting to photons. Furthermore, we demonstrate the revers

Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study

Two single nucleotide polymorphisms (SNPs), rs4415084, and rs10941679 on chromosome 5p12 were associated with risk of breast cancer in a recent genome-wide association study (GWAS) of women of European ancestry. Both SNPs are located in a large high-LD region and the causal variant(s) are still unknown. We conducted a nested case-control study in a cohort of African American women to replicate and