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Assessment of photon migration in scattering media using heterodyning techniques with a frequency modulated diode laser.

A novel technique for studying photon propagation in scattering media is proposed and demonstrated, as is believed, for the first time. Photons propagating through the medium, from a frequency-ramped single-mode diode laser, meet a reference beam from the same source, at a common detector, and beat frequencies corresponding to various temporal delays are observed by heterodyne techniques. Fourier

Studies on Potency and breadth of HIV-1, HIV-2 and SIV neutralizing antibody responses

Popular Abstract in English Thirty years after the discovery of HIV, the AIDS epidemic is still with us. While the incidence is declining globally and access to anti-retroviral therapy for low- and middle-income countries is improving, the number of new HIV infections is still high. Despite stubborn efforts to design viral immunogens, an effective formulation for the induction of broad and potent Even though the relative contribution of neutralizing antibodies (Nab) to prevent progression to AIDS during HIV-1 infection is still unclear, the induction of broadly NAb directed against HIV-1 through vaccination is considered to represent an important goal for the development of HIV-1 vaccines. Factors contributing to the induction of NAb may include the strength and duration of antigenic stimu

Study of W-boson polarisations and triple gauge boson couplings in the reaction e(+)e(-)-> W+W- at LEP 2

A determination of the single W spin density matrix (SDM) elements in the reaction e(+)e(-) -> W+W--> l nu q (q) over bar (l=e/mu) is reported at centre-of-mass energies between 189 and 209GeV. The data sample used corresponds to an integrated luminosity of 520pb(-1) taken by DELPHI between 1998 and 2000. The single W SDM elements, rho(W +/-)(tau tau') (tau,tau'=+/- 1 or 0), are determined as a fu

Novel PRRT2 mutation in an African-American family with paroxysmal kinesigenic dyskinesia

Background: Recently, heterozygous mutations in PRRT2 (Chr 16p11.2) have been identified in Han Chinese, Japanese and Caucasians with paroxysmal kinesigenic dyskinesia. In previous work, a paroxysmal kinesigenic dyskinesia locus was mapped to Chr 16p11.2 - q11.2 in a multiplex African-American family. Methods: Sanger sequencing was used to analyze all four PRRT2 exons for sequence variants in 13 p

Reproductive and Hormonal Factors, and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers: Results from the International BRCA1/2 Carrier Cohort Study

Background: Several reproductive and hormonal factors are known to be associated with ovarian cancer risk in the general population, including parity and oral contraceptive (00 use. However, their effect on ovarian cancer risk for BRCA1 and BRCA2 mutation carriers has only been investigated in a small number of studies. Methods: We used data on 2,281. BRCA1. carriers and 1,038 BRCA2 carriers from

Statin use and risk of depression: a Swedish national cohort study

Background: Statin medications, used to prevent heart disease by reducing cholesterol, also reduce inflammation and protect against oxidative damage. As inflammation and oxidative stress occur in depression, there is interest in their potential to reduce depression risk. We investigated whether use of statin medications was associated with a change in the risk of developing depression in a very la

Neutron guide-split: A high performance guide bundle concept for elliptical guides

We present a new guide-split concept for transporting cold and thermal neutrons to multiple instruments from a single beam port at a neutron facility without compromising the useful neutron brilliance notably for any of the instruments. Elliptical guides are capable of transporting an almost completely filled phase space within a large divergence (+/- 2 degrees for cold neutrons). It is therefore

The Columnar Lined Esophagus: aspects on the assessment of dysplasia and on the relationship with the esophageal submucosal glands

Columnar metaplasia, where columnar epithelium replaces the normal squamous epithelium in esophagus, is considered to be a precancerous condition in which the development of adenocarcinoma can be followed through various grades of dysplasia. The interpretation of these histological changes is subjective and suffers from considerable inter-observer variation among pathologists. In study I, we devis

Changes in self and object representations following psychotherapy measured by a theory-free, computational, semantic space method

We propose a theory-neutral, computational and data-driven method for assessing changes in semantic content of object representations following long-term psychodynamic psychotherapy. Young adults in psychotherapy are compared with an age-matched, non- clinical sample at three time points. Verbatim transcripts of descriptions of the self and parents were quantified in a semantic space constructed b

Resource allocation and disturbance rejection in web servers using SLAs and virtualized servers

Abstract—Resource management in IT–enterprises gain more and more attention due to high operation costs. For instance, web sites are subject to very changing traffic–loads over the year, over the day, or even over the minute. Online adaption to the changing environment is one way to reduce losses in the operation. Control systems based on feedback provide methods for such adaption, but is in natur

Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis

The haematopoietic stem cell (HSC) resides within a specific environment enabling it to retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is hypoxic, a milieu within which the HSC is protected from intrinsic and extrinsic stimuli. We have investigated the haematopoietic phenotype of an HSC in a mouse model where hypoxia-regulated Vegfa expression is abrogated.

Patterns of Post-Glacial Genetic Differentiation in Marginal Populations of a Marine Microalga

This study investigates the genetic structure of an eukaryotic microorganism, the toxic dinoflagellate Alexandrium ostenfeldii, from the Baltic Sea, a geologically young and ecologically marginal brackish water estuary which is predicted to support evolution of distinct, genetically impoverished lineages of marine macroorganisms. Analyses of the internal transcribed spacer (ITS) sequences and Ampl

Physiological state of female and light intensity affect the host-plant selection of carrot psyllid, Trioza apicalis (Hemiptera : Triozidae)

We have studied the effect of different light gradient regimes on host-plant selection of the carrot psyllid, Trioza apicalis Forster. In both a strong and a weak light gradient, carrot psyllids preferred a carrot leaf placed in higher light intensity. When the choice was between the host (carrot Daucus carota L.) and a non-host (barley Hordeum vulgare L.) virgin adults settled significantly more