The aim of this thesis was to identify novel potential drug targets of cardiovascular disease with a focus on G-protein coupled receptors. We identified a common genetic variant of the ATP receptor P2Y11, where an alanine is substituted with a threonine at position 87 of the P2Y11 receptor that increases the risk of developing acute myocardial infarction. Also, the Thr-87 variant of P2Y11 is asso

Recovery of electroencephalographic activity and somatosensory evoked responses was studied in paralyzed and lightly anesthetized (70% N2O) rats in which profound hypoglycemia had been induced by insulin administration. The duration of severe hypoglycemia was defined as the duration of a flat electroencephalogram (EEG) recording (5, 30, and 60 min, respectively) before restitution with glucose. Th

Popular Abstract in Swedish I min avhandling studerar jag Folke Isakssons lyriska författarskap. Jag försöker visa hur han använder sig av platsskildringar, landskapsbilder och naturelement för att framställa ett själstillstånd. Genom att inte göra en sträng uppdelning mellan yttre och inre, mellan plats och själ, åstadkommer Isaksson en speciell poetisk effekt. De platser han skildrar i sin lyrikMy study focuses on the analysis of single poems chosen as paradigmatic of Fole Isaksson's style and poetic vision. This approach is grounded in the belief that there is a certain thematic unity to Isaksson's lyric output, a unity which stems from the poet's constant preoccupation with the relations between the speaker of a poem and external nature, i.e. the place or landscape in or before which t

In January 2005 all last-term medical students in Sweden were asked to complete a questionnaire about their future career. They were asked what three medical specialties they would like to work in after graduating, what specialty they would have chosen at the time of completing the questionnaire and if they would combine future clinical work with research and teaching. Information was obtained fro

Physiological and developmental processes of plants are affected by UV-B radiation, even by the amount of UV-B in present-day sunlight. Plants also have several mechanisms to ameliorate or repair these effects and may acclimate to a certain extent to increased levels of UV-B. Nevertheless, plant growth can be directly affected by UV-B radiation. Response to UV-B also varies considerably among spec

Organic food standardization is an increasingly important strategy for dealing with consumer concerns about the environment, animal welfare, health, and the economic structure of food production. But the ways in which this consumer-oriented strategy is introduced, organized, and debated vary considerably across countries. In Sweden, a nongovernmental organization [KRAV (Association for Control of

Arrowroot starch was acid-treated using 2.2 M HCl at 29 to 30degreesC for durations of 0 to 72 h, and properties of the control and modified samples were compared. Increasing length of acid treatment produced a progressive decline in amylose blue value, intrinsic viscosity, and swelling power, as well as an increase in free sugars and solubility. Differential scanning calorimetry (DSC) studies hig

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The GAD65 epitope immunoglobulin binding pattern in cord blood of children (n=37), who later developed type 1 diabetes at 3.2-14.9 years of age, was analyzed. First, the binding at diagnosis was compared with that in the cord blood serum. The next comparison was between the cord blood serum and the mothers' serum taken at delivery. Basal GAD65 binding levels were determined in Protein A Sepharose-